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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
antiglaucoma
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "antiglaucoma" in MCE Product Catalog:
製品番号: HY-B0600
CAS 番号: 209860-87-7
別名: AFP-168; MK2452
Target:
研究分野:
Tafluprost (AFP-168) is an anti-glaucoma prostaglandin (PG) analog. Tafluprost can inhibit the apoptosis of retinal ganglion cells (RGCs) and rat RGCs cells. Tafluprost promotes axon regeneration by regulating Zn 2+-mTORpathway, inhibits intracellular lipid accumulation in human preorbital adipocytes. Tafluprost can be used in the study of optic nerve injury in glaucoma .
製品番号: HY-B1323
CAS 番号: 64019-93-8
別名: Dipivefrine hydrochloride
Category:
Alkaloids Neurological Disease Other Alkaloids Endogenous metabolite Disease Research Fields
Target:
別名: Unoprostone isopropyl ester; UF-021
Target:
研究分野:
Isopropyl unoprostone (Unoprostone isopropyl ester), an analogue of a prostaglandin metabolite, is a potent large conductance Ca 2+-activated K + (BK) channels activator. Isopropyl unoprostone has antiglaucoma effects, lowering intraocular pressure (IOP) by increasing aqueous humour outflow. Isopropyl unoprostone can improve retinal sensitivity and the protection of central retinal sensitivity .
Target:
研究分野:
PGN-9856 is a selective and high affinity (pKi ≥ 8.3) ligand at EP2 receptor. PGN-9856 is a potetn and non-prostanoid EP2 receptor agonist (pEC50 ≥ 8.5). PGN-9856 shows anti-inflammatory and anti-glaucoma activities .
製品番号: HY-130395
CAS 番号: 135646-98-9
Target:
研究分野:
15-Keto latanoprost is a metabolite of Latanoprost, which is an ocular hypotensive agent .
製品番号: HY-W031519
CAS 番号: 121-30-2
Target:
研究分野:
Chloraminophenamide (Compound 14) is a carbonic anhydrase inhibitor, with Kis of 75, 160 and 8400 nM for hCA II, bCA IV and hCA I, respectively. Chloraminophenamide has the potential for antiglaucoma research .
製品番号: HY-B1323R
CAS 番号: 64019-93-8
別名: Dipivefrine hydrochloride (Standard)
Category:
製品番号: HY-168802
CAS 番号: 261179-75-3
Target:
研究分野:
9-Keto tafluprost is a derivative of Tafluprost (HY-B0600). Tafluprost is an anti-glaucoma prostaglandin (PG) analog .
製品番号: HY-118215
CAS 番号: 1192760-33-0
別名: AGN212409
Target:
研究分野:
Aganepag ethanediol (AGN212409) is an EP2 (Prostaglandin Receptor) receptor agonist. Aganepag ethanediol may be used in anti-glaucoma research .
製品番号: HY-B1323S
別名: Dipivefrine-d6 hydrochloride
製品番号: HY-144268
Target:
研究分野:
hCAII-IN-7 (Compound R-13) is a potent human carbonic anhydrase (hCA) inhibitor with Kis of 60.7, 320.7, 2298, and 35.2 nM for hCA I, II, IV and IX, respectively .
製品番号: HY-124219
CAS 番号: 1421369-12-1
別名: 17-Phenoxy trinor PGF2α ethyl amide
Target:
研究分野:
17-Phenoxy trinor prostaglandin F2α ethyl amide (17-Phenoxy trinor PGF2α ethyl amide) is an analog of Bimatoprost (HY-12956). 17-Phenoxy trinor prostaglandin F2α ethyl amide is an agonist for Prostaglandin F2α Receptor (FP receptor). 17-Phenoxy trinor prostaglandin F2α ethyl amide is potent to reduce the intraocular pressure and attenuate the glaucoma .
製品番号: HY-124243
CAS 番号: 1138395-10-4
別名: 17-Phenyl trinor prostaglandin F2α cyclopropyl methyl amide
Target:
研究分野:
N-Cyclopropyl methyl bimatoprost (17-Phenyl trinor prostaglandin F2α cyclopropyl methyl amide) is an analog of Bimatoprost (HY-12956). N-Cyclopropyl methyl bimatoprost is an agonist for Prostaglandin F2α Receptor (FP receptor). N-Cyclopropyl methyl bimatoprost is potent to reduce the intraocular pressure and attenuate the glaucoma .
製品番号: HY-139420R
CAS 番号: 1185851-52-8
Target:
研究分野:
Tafluprost ethyl amide (Standard) is the analytical standard of Tafluprost ethyl amide (HY-139420). This product is intended for research and analytical applications. Tafluprost ethyl amide is a derivative of Tafluprost (HY-B0600). Tafluprost ethyl amide is commonly used in studies related to eyelash hypotrichosis, and it can also be applied in research related to the cosmetic field .
製品番号: HY-B0600R
CAS 番号: 209860-87-7
別名: AFP-168 (Standard); MK2452 (Standard)
Tafluprost (Standard) is the analytical standard of Tafluprost. This product is intended for research and analytical applications. Tafluprost (AFP-168) is an anti-glaucoma prostaglandin (PG) analog. Tafluprost can inhibit the apoptosis of retinal ganglion cells (RGCs) and rat RGCs cells. Tafluprost promotes axon regeneration by regulating Zn2+-mTORpathway, inhibits intracellular lipid accumulation in human preorbital adipocytes. Tafluprost can be used in the study of optic nerve injury in glaucoma [4] .
製品番号: HY-184937
Target:
COX-2/CA II-1 is an orally active dual selective inhibitor targeting COX-2 and hCA II. COX-2/CA II-1 inhibits COX-2 with an IC50 value of 0.13 μM (SI = 9.25 vs COX-1) and hCA II with a Ki value of 39.1 nM (SI = 933.8 vs hCA I). COX-2/CA II-1 demonstrates significant analgesic and anti-inflammatory effects in animal models, shows improved gastric safety with reduced ulcerogenic liability, and exhibits intraocular pressure (IOP)-lowering effects in rabbit glaucoma models. COX-2/CA II-1 can be used for anti-inflammatory, analgesic and antiglaucoma research .
製品番号: HY-184938
Target:
COX-2/CA II-2 is an orally active dual selective inhibitor targeting COX-2 and hCA II. COX-2/CA II-2 inhibits COX-2 with an IC50 value of 0.05 μM (SI = 12.02 vs COX-1) and hCA II with a Ki value of 62.6 nM (SI = 704.2 vs hCA I). COX-2/CA II-2 demonstrates significant analgesic and anti-inflammatory effects with rapid onset and sustained duration in animal models, shows improved gastric safety with reduced ulcerogenic liability, and exhibits a gradual intraocular pressure (IOP)-lowering effect without statistical significance relative to the sham-treated eye in rabbit glaucoma models. COX-2/CA II-2 can be used for anti-inflammatory, analgesic and antiglaucoma research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
