1138395-10-4
Chemical Structure
N-Cyclopropyl methyl bimatoprost
Synonym(s): 17-Phenyl trinor prostaglandin F2α cyclopropyl methyl amide
- CAS No.: 1138395-10-4
- Formula:C27H39NO4
- Molecular Weight:441.60
IUPAC Name: (Z)-N-(cyclopropylmethyl)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)cyclopentyl)hept-5-enamide
InChIKey: IBUQJJFOXZIFFM-SKHQJWOMSA-N
SMILES: O[C@H](/C=C/[C@H]1[C@@H](C[C@@H]([C@@H]1C/C=C\CCCC(NCC2CC2)=O)O)O)CCC3=CC=CC=C3
Biological Activity: N-Cyclopropyl methyl bimatoprost (17-Phenyl trinor prostaglandin F2α cyclopropyl methyl amide) is an analog of Bimatoprost (HY-12956). N-Cyclopropyl methyl bimatoprost is an agonist for Prostaglandin F2α Receptor (FP receptor). N-Cyclopropyl methyl bimatoprost is potent to reduce the intraocular pressure and attenuate the glaucoma[1][2].
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N-Cyclopropyl methyl bimatoprost | N-Cyclopropyl methyl bimatoprost (17-Phenyl trinor prostaglandin F2α cyclopropyl methyl amide) is an analog of Bimatoprost (HY-12956). N-Cyclopropyl methyl bimatoprost is an agonist for Prostaglandin F2α Receptor (FP receptor). N-Cyclopropyl methyl bimatoprost is potent to reduce the intraocular pressure and attenuate the glaucoma. | |||||||||||||||||||||
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References
- [1]. Balapure AK, et al., Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2 alpha receptor. Implications for development of a photoaffinity probe. Biochem Pharmacol. 1989 Jul 15;38(14):2375-81. [Content Brief]
- [2]. Woodward DF, et al., Pharmacological characterization of a novel antiglaucoma agent, Bimatoprost (AGN 192024). J Pharmacol Exp Ther. 2003 May;305(2):772-85. [Content Brief]
