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Tafluprost (Synonyms: AFP-168; MK2452)

Cat. No.: HY-B0600 Purity: 98.07%
Handling Instructions

Tafluprost(AFP-168) is an anti-glaucoma prostaglandin (PG) analog.

For research use only. We do not sell to patients.

Tafluprost Chemical Structure

Tafluprost Chemical Structure

CAS No. : 209860-87-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
25 mg USD 240 In-stock
Estimated Time of Arrival: December 31
50 mg USD 390 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

Tafluprost(AFP-168) is an anti-glaucoma prostaglandin (PG) analog. Target:Others Tafluprost showed significant IOP-lowering effects without any safety concerns in patients with various types of glaucoma and OH in daily clinical practice and tafluprost is highly effective in any therapeutic patterns [1]. Tafluprost with reduced BAK has potential as a superior antiglaucoma drug, not only for its IOP-lowering effect, but also for its good corneal safety profile [2]. Tafluprost single-use vials treatment was effective in reducing IOP over the 3 years of this study, but visual field performance worsened by 10.3%-13.8% in patients with normal-tension glaucoma. Safety was satisfactory [3].

Clinical Trial
Molecular Weight

452.53

Formula

C₂₅H₃₄F₂O₅

CAS No.

209860-87-7

SMILES

O=C(OC(C)C)CCC/C=C\C[[email protected]@H]1[[email protected]@H](/C=C/C(F)(F)COC2=CC=CC=C2)[[email protected]](O)C[[email protected]@H]1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 270 mg/mL (596.65 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2098 mL 11.0490 mL 22.0980 mL
5 mM 0.4420 mL 2.2098 mL 4.4196 mL
10 mM 0.2210 mL 1.1049 mL 2.2098 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.25 mg/mL (4.97 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.25 mg/mL (4.97 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.25 mg/mL (4.97 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

TafluprostAFP-168 MK2452AFP168AFP 168MK2452MK 2452MK-2452OthersInhibitorinhibitorinhibit

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Tafluprost
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