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Cat. No.: HY-144268

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hCAII-IN-7

hCAII-IN-7 (Compound R-13) is a potent human carbonic anhydrase (hCA) inhibitor with K_is of 60.7, 320.7, 2298, and 35.2 nM for hCA I, II, IV and IX, respectively.

For research use only. We do not sell to patients.

Formula: C₂₀H₂₅N₃O₄S
Molecular Weight:403.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

hCAII-IN-7 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

hCAII-IN-7 (Compound R-13) is a potent human carbonic anhydrase (hCA) inhibitor with K_is of 60.7, 320.7, 2298, and 35.2 nM for hCA I, II, IV and IX, respectively^[1].

All Carbonic Anhydrase Isoforms :

Chemical Information

Molecular Weight 403.50
Formula C₂₀H₂₅N₃O₄S
SMILES

NS(=O)(C1=CC=C(C=C1)C(N2CCN(C[C@H]2CCO)CC3=CC=CC=C3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chiaramonte N, et al. 2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity. Eur J Med Chem. 2022;228:114026. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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Chemical Information
Purity & Documentation
References

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hCAII-IN-7

All Carbonic Anhydrase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

hCAII-IN-7 Related Classifications

HY-144268 Related Classifications