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bronchiectasis

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19

Inhibitors & Agonists

1

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-136205
    IA-Alkyne
    4 Publications Verification

    Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide

    		 TRP Channel Infection Inflammation/Immunology
    IA-Alkyne (Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel (TRPC) agonist and has the potential for the study of respiratory infection . IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling . IA-Alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    IA-Alkyne
  • HY-B0944
    Pidotimod
    2 Publications Verification

    		 Bacterial Inflammation/Immunology
    Pidotimod is an orally active dipeptide immunostimulant with immunomodulatory properties on the adaptive and the innate immune responses. Pidotimod increases macrophage activity and humoral immune functions. Pidotimod can be used for the research of chronic bronchitis, chronic obstructive pulmonary disease (COPD), bronchiectasis, and chronic idiopathic urticaria,et al .
    Pidotimod
  • HY-103431
    A68930 hydrochloride
    1 Publications Verification

    		 Dopamine Receptor Others
    A68930 hydrochloride, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis .
    A68930 hydrochloride
  • HY-13628
    Etalocib
    2 Publications Verification

    LY293111; VML 295

    		 Leukotriene Receptor Apoptosis Inflammation/Immunology Cancer
    Etalocib (LY293111), an orally active leukotriene B4 receptor antagonist, inhibits the binding of [ 3H]LTB4, with a Ki of 25 nM. Etalocib (LY293111) prevents LTB4-induced calcium mobilization with an lC50 of 20 nM. Etalocib (LY293111) induces apoptosis .
    Etalocib
  • HY-112318A
    GSK-2793660

    		Cathepsin Inflammation/Immunology
    GSK-2793660 is an orally active and irreversible inhibitor of Cathepsin C (CTSC). GSK-2793660 can be used for the research of bronchiectasis .
    GSK-2793660
  • HY-172242
    Verducatib

    		Cathepsin Dipeptidyl Peptidase Inflammation/Immunology
    Verducatib (BI 1291583) is an orally active inhibitor of cathepsin C (also known as DPP1). Verducatib restores the protease-inhibitor balance by inhibiting the activation of neutrophil serine proteases, thereby alleviating pulmonary inflammation and regulating infection responses. Verducatib significantly reduces the risk (including severe exacerbations) and frequency of acute exacerbations in bronchiectasis (BE). Verducatib also improves lung function and quality of life, and shortens the duration of antibiotic use. The overall incidence of adverse events of Verducatib is comparable to that of placebo, with only slightly more mild-to-moderate cutaneous adverse events observed in the high-dose group, demonstrating promising clinical application potential .
    Verducatib
  • HY-120709
    Propyl-GSK-2793660 hydrochloride

    		Dipeptidyl Peptidase Inflammation/Immunology
    Propyl-GSK-2793660 hydrochloride (compound 1) is a irreversible and covalent DPP1 inhibitor. Propyl-GSK-2793660 hydrochloride can be used for the study of bronchiectasis .
    Propyl-GSK-2793660 hydrochloride
  • HY-112318
    GSK-2793660 free base

    		Cathepsin Inflammation/Immunology
    GSK-2793660 (free base) is an oral, irreversible inhibitor of Cathepsin C (CTSC). GSK-2793660 (free base) can be used for the research of bronchiectasis .
    GSK-2793660 free base
  • HY-160073
    Florensocatib

    		Dipeptidyl Peptidase Inflammation/Immunology
    Florensocatib (compound 1) is a potent inhibitor of DPP1. Florensocatib can used in study bronchiectasis .
    Florensocatib
  • HY-120687
    A68930

    		Dopamine Receptor Cancer
    A68930, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis .
    A68930
  • HY-B0944R
    Pidotimod (Standard)

    		Reference Standards Bacterial Inflammation/Immunology
    Pidotimod (Standard) is the analytical standard of Pidotimod. This product is intended for research and analytical applications. Pidotimod is an orally active dipeptide immunostimulant with immunomodulatory properties on the adaptive and the innate immune responses. Pidotimod increases macrophage activity and humoral immune functions. Pidotimod can be used for the research of chronic bronchitis, chronic obstructive pulmonary disease (COPD), bronchiectasis, and chronic idiopathic urticaria,et al .
    Pidotimod (Standard)
  • HY-167937
    Propyl-GSK-2793660

    		Dipeptidyl Peptidase Inflammation/Immunology
    Propyl-GSK-2793660 (compound 1) is a irreversible and covalent DPP1 inhibitor. Propyl-GSK-2793660 can be used for the study of bronchiectasis .
    Propyl-GSK-2793660
  • HY-128043
    11-Deoxy prostaglandin E1

    AY-23578; Doproston B; 11-Deoxy-PGE1

    		 Prostaglandin Receptor Inflammation/Immunology
    11-Deoxy prostaglandin E1 (AY-23578; Doproston B) is an analog of prostaglandin E1 (PGE1) with bronchodilator activity. 11-Deoxy prostaglandin E1 inhibits histamine-induced bronchoconstriction and causes relaxation of tracheal strips in isolated guinea pigs .
    11-Deoxy prostaglandin E1
  • HY-13628A
    Etalocib sodium

    LY293111 sodium; VML 295 sodium

    		 Leukotriene Receptor Apoptosis Inflammation/Immunology Cancer
    Etalocib (LY293111) sodium, an orally active leukotriene B4 receptor antagonist, inhibits the binding of [ 3H]LTB4, with a Ki of 25 nM. Etalocib sodium prevents LTB4-induced calcium mobilization with an lC50 of 20 nM. Etalocib sodium induces apoptosis .
    Etalocib sodium
  • HY-13628R
    Etalocib (Standard)

    LY293111 (Standard); VML 295 (Standard)

    		 Leukotriene Receptor Apoptosis Reference Standards Inflammation/Immunology Cancer
    Etalocib (Standard) is the analytical standard of Etalocib. This product is intended for research and analytical applications. Etalocib (LY293111), an orally active leukotriene B4 receptor antagonist, inhibits the binding of [3H]LTB4, with a Ki of 25 nM. Etalocib (LY293111) prevents LTB4-induced calcium mobilization with an lC50 of 20 nM. Etalocib (LY293111) induces apoptosis .
    Etalocib (Standard)
  • HY-103431R
    A68930 hydrochloride (Standard)

    		Reference Standards Dopamine Receptor Others
    A68930 hydrochloride (Standard) is the analytical standard of A68930 hydrochloride (HY-103431). This product is intended for research and analytical applications. A68930 hydrochloride, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis .
    A68930 hydrochloride (Standard)
  • HY-182465
    CHF-6333 chloride

    		Elastase Inflammation/Immunology
    CHF-6333 chloride is a neutrophil elastase (NE) inhibitor (IC50 = 0.21 nM; KD = 0.16 nM). CHF-6333 chloride retains its activity in both human (IC50 = 0.22 nM) and rat (IC50 = 3.63 nM) proteases. CHF-6333 chloride exhibits inhibitory activity against Proteinase 3 (IC50 = 22 nM). CHF-6333 chloride can be used for the study of bronchiectasis (BE) .
    CHF-6333 chloride
  • HY-179566
    CHF-6333

    		Elastase Inflammation/Immunology
    CHF-6333 is a neutrophil elastase (NE) inhibitor (IC50 = 0.21 nM; KD = 0.16 nM). CHF-6333 retains its activity in both human (IC50 = 0.22 nM) and rat (IC50 = 3.63 nM) proteases. CHF-6333 exhibits inhibitory activity against Proteinase 3 (IC50 = 22 nM). CHF-6333 can be used for the study of bronchiectasis (BE) .
    CHF-6333
  • HY-179566A
    CHF-6333 xinafoate

    		Elastase Inflammation/Immunology
    CHF-6333 xinafoate is a neutrophil elastase (NE) inhibitor (IC50 = 0.21 nM; KD = 0.16 nM). CHF6333 xinafoate retains its activity in both human (IC50 = 0.22 nM) and rat (IC50 = 3.63 nM) proteases. CHF6333 xinafoate exhibits inhibitory activity against Proteinase 3 (IC50 = 22 nM). CHF-6333 xinafoate can be used for the study of bronchiectasis (BE) .
    CHF-6333 xinafoate

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