1613458-70-0
1613458-70-0
Chemical Structure
GSK-2793660 free base
- CAS No.: 1613458-70-0
- Formula:C20H27N3O3
- Molecular Weight:357.45
IUPAC Name: (S,E)-4-amino-N-(6-(indolin-1-yl)-6-oxohex-4-en-3-yl)tetrahydro-2H-pyran-4-carboxamide
InChIKey: IVMRHVTWOHFAKG-WAVCKPEOSA-N
SMILES: NC1(C(N[C@@H](CC)/C=C/C(N2CCC3=C2C=CC=C3)=O)=O)CCOCC1
Biological Activity: GSK-2793660 (free base) is an oral, irreversible inhibitor of Cathepsin C (CTSC). GSK-2793660 (free base) can be used for the research of bronchiectasis[1][2].
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GSK-2793660 free base | GSK-2793660 (free base) is an oral, irreversible inhibitor of Cathepsin C (CTSC). GSK-2793660 (free base) can be used for the research of bronchiectasis. | |||||||||||||||||||||
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References
- [1]. Szcześniak P, et al. The Synthesis of α,α-Disubstituted α-Amino Acids via Ichikawa Rearrangement. J Org Chem. 2016 Feb 5;81(3):1057-74. [Content Brief]
- [2]. Miller BE, et al. Epithelial desquamation observed in a phase I study of an oral cathepsin C inhibitor (GSK2793660). Br J Clin Pharmacol. 2017 Dec;83(12):2813-2820. [Content Brief]
