2762114-61-2
2762114-61-2
Chemical Structure
Florensocatib
Synonym(s): HSK31858
- CAS 番号: 2762114-61-2
- Formula:C23H23FN4O4
- Molecular Weight:438.45
InChIKey: ONJDRXNRBKHINH-UWJYYQICSA-N
SMILES: CN1C2=CC(C3=CC(F)=C(C=C3)C[C@@H](C#N)NC([C@@H]4CNCCCO4)=O)=CC=C2OC1=O
Biological Activity: Florensocatib (HSK31858) is a potent reversible dipeptidyl peptidase 1 (DPP1) inhibitor with an IC50 of 1.6 nM against DPP1. By inhibiting the DPP1-dependent maturation of neutrophil serine proteases (NSPs), Florensocatib can be used in studies of bronchiectasis and neutrophilic inflammation[1][2].
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Florensocatib | Florensocatib (HSK31858) is a potent reversible dipeptidyl peptidase 1 (DPP1) inhibitor with an IC50 of 1.6 nM against DPP1. By inhibiting the DPP1-dependent maturation of neutrophil serine proteases (NSPs), Florensocatib can be used in studies of bronchiectasis and neutrophilic inflammation. | |||||||||||||||||||||
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References
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[1]. Zhong N, et al. Florensocatib in adults with bronchiectasis: The HOPE-BE trial protocol and baseline demographic characteristics. ERJ Open Research. 2026; in press.
- [2]. Fan J, et al. Dipeptidyl peptidase 1 inhibitor polymorph, preparation method and use therefor. WO2023160579A1. World Intellectual Property Organization. 2023-08-31.
