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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
chiral HPLC
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "chiral HPLC" in MCE Product Catalog:
Cat. No.: HY-134200
CAS No.: 29541-66-0
Target:
Cat. No.: HY-I0169
CAS No.: 196601-69-1
Target:
Research Areas:
(R)-Amino-N-benzyl-3-methoxypropionamide is a key intermediate for the synthesis of the antiepileptic agent (R)-Lacosamide. To improve its chiral purity and chemical stability, (R)-Amino-N-benzyl-3-methoxypropionamide can react with phosphoric acid to form a phosphate salt. Detected by high performance liquid chromatography (HPLC), this phosphate salt exhibits extremely high chiral purity, with the content of the R-enantiomer reaching up to 99.37% .
Cat. No.: HY-W688565
CAS No.: 18944-28-0
Target:
Research Areas:
(2S)-2-Amino-1-hydroxyoctadecan-3-one is the product generated by the decarboxylative condensation of L-serine and palmitoyl-CoA catalyzed by serine palmitoyltransferase (SPT) .
Cat. No.: HY-112653
CAS No.: 98462-03-4
Synonyms: 8(S)-Hydroxyeicosatetraenoic acid
Target:
Research Areas:
8(S)-HETE (8(S)-Hydroxyeicosatetraenoic acid) is a major lipoxygenase product in PMA-treated murine epidermis. It activates mouse keratinocyte protein kinase C with an IC50 of 100 μM. 8(S)-HETE also activates PPARα selectively at concentrations as low as 0.3 μM. Stereochemical assignment of the (S) enantiomer is based on comparison of chiral HPLC retention times to published results.
Cat. No.: HY-120460
CAS No.: 105500-09-2
Synonyms: 8(R)-Hydroxyeicosatetraenoic acid
Target:
Research Areas:
8(R)-HETE is biosynthesized by lipoxygenation of arachidonic acid in marine invertebrates such as gorgonian corals and starfish. Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results.
Cat. No.: HY-115408
CAS No.: 107656-14-4
Synonyms: 9(R)-Hydroxyeicosatetraenoic acid
Target:
Research Areas:
9(R)-HETE is an enantiomer which makes up 50% of (±)9-HETE. At a concentration of 300 nM, 9(R)-HETE activates RXRγ-dependent transcription 1.5 fold relative to a control.1 Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results.
Cat. No.: HY-183199
CAS No.: 149751-70-2
Target:
Research Areas:
(2R)-2-(2-Aminoacetamido)butanoic acid is an N-blocked amino acid .
Cat. No.: HY-184758
CAS No.: 10567-22-3
Research Areas:
3-O-Octadecyl-sn-glycerol is an ether lipid that serves as an enantiopure substrate for evaluating the stereoselectivity of lipases in oleic acid esterification reactions. 3-O-Octadecyl-sn-glycerol can be used for the synthesis of AZT-lipid-PFA antiviral dual drugs. 3-O-Octadecyl-sn-glycerol acts as a biochemical reagent for research in various fields .
Cat. No.: HY-L903
5,281 compounds
Fragment-based drug discovery (FBDD) is well suited for discovering both drug leads and chemical probes of protein function. 3-dimensionality (3D) diversity is pivotal because the molecular shape is one of the most important factors in molecular recognition by a biomolecule. There is a developing appreciation that 3D fragments could offer opportunities that are not provided by 2D fragments.
MCE 3D Diverse Fragment Library consists of 5,400 non-flat fragment-like molecules (average Fsp3 value 0.58). More than 4,700 fragment compounds contain at least one chiral center in the structure. The key concepts that underlie the library design were 3D shape, structural diversity, reactive functionality and fragment-like. This 3D Diverse Fragment Library brings higher fragment hit optimization and increases the likelihood to find innovative hits in FBDD.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
