(R)-Amino-N-benzyl-3-methoxypropionamide

Art. -Nr.: HY-I0169 Reinheit: 99.95% ee.: 96.45%: Data Sheet
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Handling Instructions
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(R)-Amino-N-benzyl-3-methoxypropionamide is a key intermediate for the synthesis of the antiepileptic agent (R)-Lacosamide. To improve its chiral purity and chemical stability, (R)-Amino-N-benzyl-3-methoxypropionamide can react with phosphoric acid to form a phosphate salt. Detected by high performance liquid chromatography (HPLC), this phosphate salt exhibits extremely high chiral purity, with the content of the R-enantiomer reaching up to 99.37%.

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(R)-Amino-N-benzyl-3-methoxypropionamide Chemische Struktur

CAS. Nr. : 196601-69-1

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10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
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10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
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Other Forms of (R)-Amino-N-benzyl-3-methoxypropionamide:

(R)-Amino-N-benzyl-3-methoxypropionamide (Standard) Angebot einholen

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

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Beschreibung

In Vitro

The free base of (R)-Amino-N-benzyl-3-methoxypropionamide (compound 10) shows poor chiral stability, with its chiral purity dropping from 95.66% to nearly 50% within 12 months of storage; in contrast, when formulated as its phosphate salt, its chiral purity increases to 99.37%, its chemical purity reaches 100%, and no chiral degradation is observed within 12 months^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

208.26

Formel

C₁₁H₁₆N₂O₂

CAS. Nr.

196601-69-1

Appearance

Solid-Liquid Mixture

Color

Colorless to off-white

SMILES

O=C(NCC1=CC=CC=C1)[C@H](N)COC

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (480.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.8017 mL	24.0085 mL	48.0169 mL
5 mM	0.9603 mL	4.8017 mL	9.6034 mL
10 mM	0.4802 mL	2.4008 mL	4.8017 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

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Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 99.95% ee.: 96.45%

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Data Sheet (270 KB) SDS (393 KB)

COA (246 KB) HNMR (120 KB) RP-HPLC (101 KB) NP-HPLC (214 KB) LCMS (326 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Yang A, et al. Improved synthesis and impurity identification of (R)-lacosamide[J]. Organic Process Research & Development, 2019, 23(5): 818-824.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.8017 mL	24.0085 mL	48.0169 mL	120.0423 mL
	5 mM	0.9603 mL	4.8017 mL	9.6034 mL	24.0085 mL
	10 mM	0.4802 mL	2.4008 mL	4.8017 mL	12.0042 mL
	15 mM	0.3201 mL	1.6006 mL	3.2011 mL	8.0028 mL
	20 mM	0.2401 mL	1.2004 mL	2.4008 mL	6.0021 mL
	25 mM	0.1921 mL	0.9603 mL	1.9207 mL	4.8017 mL
	30 mM	0.1601 mL	0.8003 mL	1.6006 mL	4.0014 mL
	40 mM	0.1200 mL	0.6002 mL	1.2004 mL	3.0011 mL
	50 mM	0.0960 mL	0.4802 mL	0.9603 mL	2.4008 mL
	60 mM	0.0800 mL	0.4001 mL	0.8003 mL	2.0007 mL
	80 mM	0.0600 mL	0.3001 mL	0.6002 mL	1.5005 mL
	100 mM	0.0480 mL	0.2401 mL	0.4802 mL	1.2004 mL