3-O-Octadecyl-sn-glycerol
3-O-Octadecyl-sn-glycerol is an ether lipid that serves as an enantiopure substrate for evaluating the stereoselectivity of lipases in oleic acid esterification reactions. 3-O-Octadecyl-sn-glycerol can be used for the synthesis of AZT-lipid-PFA antiviral dual drugs. 3-O-Octadecyl-sn-glycerol acts as a biochemical reagent for research in various fields.
For research use only. We do not sell to patients.
- CAS No.: 10567-22-3
- Formula: C21H44O3
- Molecular Weight:344.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
3-O-Octadecyl-sn-glycerol serves as a lipid-linked scaffold for the synthesis of the antiviral bimolecular conjugate AZT-lipid-PFA. This conjugate can be enzymatically hydrolyzed to generate a variety of antiviral metabolites, exerting additive or synergistic antiviral effects[1].
3-O-Octadecyl-sn-glycerol acts as enantiopure reference substrate to test lipase stereoselectivity via chiral HPLC analysis of 3,5-dinitrophenylurethane derivatives, and helps confirm reversible organic solvent inhibition of lipase esterification catalysis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 10567-22-3
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Molecular Weight 344.57
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Formula C21H44O3
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SMILES
CCCCCCCCCCCCCCCCCCOC[C@H](O)CO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Schott H, et al. Synthesis and in vitro activities of a new antiviral duplex drug linking Zidovudine (AZT) and Foscarnet (PFA) via an octadecylglycerol residue. Bioorganic & medicinal chemistry. 2009 Jan 01;17(1):303-10. [Content Brief]
[2]. Meusel D, et al. Stereoselectivity of lipases: esterification reactions of octadecylglycerol. Chemistry and physics of lipids. 1992 Apr;61(2):193-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
3-O-Octadecyl-sn-glycerol Related Classifications
HY-184758 Related Classifications
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Keywords
- 3-O-Octadecyl-sn-glycerol
- 10567-22-3
- Biochemical Assay Reagents
- Drug Intermediate
- 3,5-dinitrophenylurethane derivatives
- lipase
- ether lipid
- AZT-lipid-PFA antiviral duplex drug
- herpes simplex virus infection
- oleic acid esterification reactions
- human immunodeficiency virus infection
- sn-3 enantiomer
- chiral HPLC
- human cytomegalovirus infection
- Inhibitor
- inhibitor
- inhibit