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diseas

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) ADC Linker (2) AMPK (1) Amyloid-β (1) Apolipoprotein (2) Drug Derivative (1) Glycosidase (1) Reference Standards (1) TMPRSS6 (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (2) Metabolic Disease (3) Neurological Disease (4)
Oligonucleotides:	Antisense Oligonucleotides (1)

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103076

EZ-482 1 Publications Verification	Apolipoprotein	Neurological Disease
EZ-482, a novel ligand of apolipoprotein (apoE), binds to sites on apoE in the C-terminal domain with K_ds of 5-10 μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimer’s diseas .

HY-N16614

Ent-Calquiquelignan E	Acyltransferase	Metabolic Disease
Ent-Calquiquelignan E (Compound 8) is a flavonoid lignan compound. Ent-Calquiquelignan E can selectively inhibit diacylglycerol acyltransferase 1 (DGAT1) with an IC₅₀ of 71.5 μM. Ent-Calquiquelignan E can be used for the research of metabolic diseas .

HY-129371

SPDV	ADC Linker	Cancer
SPDV is a cleavable ADC linker used for diagnosis and treatment of cancer or B cell proliferative diseas.

HY-177662A

Sapablursen sodium IONIS-TMPRSS6-Lrx sodium; ISIS 702843 sodium	TMPRSS6	Metabolic Disease
Sapablursen sodium, an antisense oligonucleotide, is designed to reduce the production of TMPRSS6 resulting in increased expression of hepcidin, which is the key regulator of iron homeostasis. Sapablursen sodium can be used in the research of blood diseas

HY-129374

SPDH	ADC Linker	Cancer
SPDH is a cleavable ADC linker used for diagnosis and treatment of cancer or B cell proliferative diseas.

HY-148210

AMPK activator 9	AMPK	Metabolic Disease
AMPK activator 9 (ZM-6) is a potent AMPK (α2β1γ1) activator with an EC₅₀ value of 1.1 µM. AMPK activator 9 has the potential for the research of type 2 diabetes .

HY-P11314

ABri	Amyloid-β	Cardiovascular Disease Neurological Disease
ABri, 34 amino acids long, is an Amyloid subunit with certain degree of N- and C-terminal heterogeneity and no sequence identity to any known amyloid protein. ABri is devoid of glycine, methionine, proline, aspartic acid, tryptophane, tyrosine and glutamine, featuring pyroglutamate at its N-terminus. ABri can be used for cerebral hemorrhages, ischemic infarction and Alzheimer disease research .

HY-103076R

EZ-482 (Standard)	Apolipoprotein Reference Standards	Neurological Disease
EZ-482 (Standard) is the analytical standard of EZ-482 (HY-103076). This product is intended for research and analytical applications. EZ-482, a novel ligand of apolipoprotein (apoE), binds to sites on apoE in the C-terminal domain with Kds of 5-10 μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimer’s diseas .

HY-171241

Imolamine	Drug Derivative	Cardiovascular Disease
Imolamine is a potent antiplatelet aggregation agent, is a phenyl aminoxidiazole derivative. Imolamine has the potential for the research of coronary heart disease .

HY-131570

JZ-4109	Glycosidase	Neurological Disease
JZ-4109 is a β-Glucocerebrosidase (GCase) modulator with an IC₅₀ of 8 nM for wild-type recombinant GCase. JZ-4109 binds to an allosteric site at the GCase dimer interface, stabilizes wild-type and GCase ^N370S mutant GCase, induces GCase dimerization. JZ-4109 increases GCase protein abundance. JZ-4109 can be used for the research of Parkinson's diseas .

Cat. No.	Product Name	Target	Research Area

HY-P11314

ABri	Amyloid-β	Cardiovascular Disease Neurological Disease
ABri, 34 amino acids long, is an Amyloid subunit with certain degree of N- and C-terminal heterogeneity and no sequence identity to any known amyloid protein. ABri is devoid of glycine, methionine, proline, aspartic acid, tryptophane, tyrosine and glutamine, featuring pyroglutamate at its N-terminus. ABri can be used for cerebral hemorrhages, ischemic infarction and Alzheimer disease research .

Ent-Calquiquelignan E	Structural Classification Flavonoids Flavones Akebia quinata (Houttuyn) Decaisne Terpenoids Lardizabalaceae Sesquiterpenes Plants Source Classification	Acyltransferase
Ent-Calquiquelignan E (Compound 8) is a flavonoid lignan compound. Ent-Calquiquelignan E can selectively inhibit diacylglycerol acyltransferase 1 (DGAT1) with an IC₅₀ of 71.5 μM. Ent-Calquiquelignan E can be used for the research of metabolic diseas .

Cat. No.	Product Name		Classification

HY-177662A

Sapablursen sodium IONIS-TMPRSS6-Lrx sodium; ISIS 702843 sodium		Antisense Oligonucleotides
Sapablursen sodium, an antisense oligonucleotide, is designed to reduce the production of TMPRSS6 resulting in increased expression of hepcidin, which is the key regulator of iron homeostasis. Sapablursen sodium can be used in the research of blood diseas

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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