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EZ-482 

Cat. No.: HY-103076
Handling Instructions

EZ-482, a novel ligand of apolipoprotein (apoE), binds to sites on apoE in the C-terminal domain with Kds of 5-10 μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimer’s diseas.

For research use only. We do not sell to patients.

EZ-482 Chemical Structure

EZ-482 Chemical Structure

CAS No. : 1016456-76-0

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Description

EZ-482, a novel ligand of apolipoprotein (apoE), binds to sites on apoE in the C-terminal domain with Kds of 5-10 μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimer’s diseas[1].

IC50 & Target

Kd: 5-10 μM (apoE3 and apoE4)[1]

In Vitro

EZ-482 binds to sites on apoE in the C-terminal domain encompassing residues 229-243 and 258-265[1].
EZ-482 (0.5, 1, 5, 10 μM; 1 hour) blocks heparin binding in a concentration-dependent manner[1].

Molecular Weight

498.94

Formula

C₂₃H₁₉ClN₄O₅S

CAS No.

1016456-76-0

SMILES

O=C(NC1=CC(S(=O)(NC2=CC=CC(Cl)=C2)=O)=CC=C1O)CC3=NN(C)C(C4=C3C=CC=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

EZ-482EZ482EZ 482OthersligandapolipoproteinapoEC-terminaldomainapoE3apoE4N-terminalallostericAlzheimer’sdiseasheparinInhibitorinhibitorinhibit

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EZ-482
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HY-103076
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