1016456-76-0
1016456-76-0
Chemical Structure
EZ-482
- CAS No.: 1016456-76-0
- Formula:C23H19ClN4O5S
- Molecular Weight:498.94
IUPAC Name: N-(5-(N-(3-chlorophenyl)sulfamoyl)-2-hydroxyphenyl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
InChIKey: CLWDCBBEVQRZLY-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(S(=O)(NC2=CC=CC(Cl)=C2)=O)=CC=C1O)CC3=NN(C)C(C4=C3C=CC=C4)=O
Biological Activity: EZ-482, a novel ligand of apolipoprotein (apoE), binds to sites on apoE in the C-terminal domain with Kds of 5-10 μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimer’s diseas[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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EZ-482 | 97.21% | EZ-482, a novel ligand of apolipoprotein (apoE), binds to sites on apoE in the C-terminal domain with Kds of 5-10 μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimer’s diseas. | ||||||||||||||||||||
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EZ-482 (Standard) | ≥98% | EZ-482 (Standard) is the analytical standard of EZ-482 (HY-103076). This product is intended for research and analytical applications. EZ-482, a novel ligand of apolipoprotein (apoE), binds to sites on apoE in the C-terminal domain with Kds of 5-10 μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimer’s diseas. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.56
HY-168561NLRP3-IN-58 -
Similarity Score 0.55
HY-112798PH-002 -
Similarity Score 0.54
HY-147027PARP-1-IN-2 -
Similarity Score 0.53
HY-147030PARP1-IN-8 -
Similarity Score 0.52
HY-155457Enpp-1-IN-19 -
Similarity Score 0.52
HY-155473Phosphatidylcholine transfer protein inhibitor-2 -
Similarity Score 0.50
HY-168523S1647 -
Similarity Score 0.50
HY-111467Mcl1-IN-4 -
Similarity Score 0.50
HY-W801893FGFR1 inhibitor-13 -
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