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Cat. No.: HY-168561

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NLRP3-IN-58

NLRP3-IN-58 (Compound DS15) is an inhibitor for the activation of NLRP3 inflammasome with an IC₅₀ of 3.85 μM, and inhibits 33% IL-1β release at a concentration of 10 μM.

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CAS No.: 2956014-05-2
화학식: C₂₂H₁₈ClN₃O₃S
분자량:439.91

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

NLRP3-IN-58 Chemical Structure

CAS No.: 2956014-05-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

NLRP3-IN-58 (Compound DS15) is an inhibitor for the activation of NLRP3 inflammasome with an IC₅₀ of 3.85 μM, and inhibits 33% IL-1β release at a concentration of 10 μM^[1].

All NOD-like Receptor (NLR) Isoforms :

All Interleukin Related Isoforms :

Chemical Information

CAS No. 2956014-05-2
분자량 439.91
화학식 C₂₂H₁₈ClN₃O₃S
SMILES

O=C(NC1=CC=CC(S(=O)(NC2=CC=CC=C2)=O)=C1)CC3=CNC4=CC(Cl)=CC=C34
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. El-Sayed S, et al., Virtual screening-led design of inhibitor scaffolds for the NLRP3 inflammasome. Bioorg Chem. 2024 Oct 22;153:107909. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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NLRP3-IN-58

All NOD-like Receptor (NLR) Isoforms

All Interleukin Related Isoforms