1997359-63-3
Chemical Structure
JZ-4109
- CAS No.: 1997359-63-3
- Formula:C22H18N4
- Molecular Weight:338.41
IUPAC Name: N-(2,3-dihydro-1H-inden-2-yl)-2-(pyridin-3-yl)quinazolin-4-amine
InChIKey: XXCCBJLQMRHXKM-UHFFFAOYSA-N
SMILES: N1=CC=CC(=C1)C2=NC=3C=CC=CC3C(=N2)NC4CC=5C=CC=CC5C4
Biological Activity: JZ-4109 is a β-Glucocerebrosidase (GCase) modulator with an IC50 of 8 nM for wild-type recombinant GCase. JZ-4109 binds to an allosteric site at the GCase dimer interface, stabilizes wild-type and GCaseN370S mutant GCase, induces GCase dimerization. JZ-4109 increases GCase protein abundance. JZ-4109 can be used for the research of Parkinson's diseas[1].
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JZ-4109 | JZ-4109 is a β-Glucocerebrosidase (GCase) modulator with an IC50 of 8 nM for wild-type recombinant GCase. JZ-4109 binds to an allosteric site at the GCase dimer interface, stabilizes wild-type and GCaseN370S mutant GCase, induces GCase dimerization. JZ-4109 increases GCase protein abundance. JZ-4109 can be used for the research of Parkinson's diseas. | |||||||||||||||||||||
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Keywords
