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Results for "

fluorine

" in MedChemExpress (MCE) Product Catalog:

53

Inhibitors & Agonists

1

Screening Libraries

1

Fluorescent Dyes

8

Biochemical Assay Reagents

3

Peptides

1

Isotope-Labeled Compounds

2

Click Chemistry

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-Y0971
    Tetrabutylammonium fluoride (solution),1M in THF

    TBAF

    		 Biochemical Assay Reagents Others
    Tetrabutylammonium fluoride is an organic compound containing both ammonium and fluorine functional groups. It is commonly used as a reagent in various chemical synthesis applications, especially as a source of fluoride ions for nucleophilic reactions. Tetrabutylammonium fluoride has several properties that make it suitable for these applications, including its high solubility in polar solvents and its ability to selectively activate certain chemical bonds. In addition, it can be used as a catalyst for organic reactions and as an electrolyte for batteries.
    Tetrabutylammonium fluoride (solution),1M in THF
  • HY-106014
    Tezacitabine

    		DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Apoptosis Cancer
    Tezacitabine is a cytostatic and cytotoxic antimetabolite and a nucleoside analogue. Tezacitabine irreversibly inhibits the ribonucleotide reductase and interferes with DNA replication and repair. Tezacitabine effectively induces cells apoptotic. Tezacitabine has the potential for leukemias and solid tumors (carcinomas) treatment .
    Tezacitabine
  • HY-45409
    DMT-2′Fluoro-dU Phosphoramidite

    2'-F-dU Phosphoramidite

    		 Phosphoramidites Nucleoside Antimetabolite/Analog Cancer
    DMT-2’ Fluoro-dU Phosphoramidite (2'-F-dU Phosphoramidite) is a uridine phosphoramidite with a fluorine in the 2’ position. DMT-2’ Fluoro-dU Phosphoramidite could be used for nucleoside modification and synthesis of DNA .
    DMT-2′Fluoro-dU Phosphoramidite
  • HY-34717
    Tetrabutylammonium tetrafluoroborate

    Tetra-n-butylammonium tetrafluoroborate

    		 Biochemical Assay Reagents Others
    Tetrabutylammonium tetrafluoroborate is an inorganic salt commonly used in organic synthesis reactions and electrochemical applications. It is usually used as a catalyst or reagent, and is widely used in the field of organic synthesis, such as fluorination reaction, olefin addition and cyclization reaction, etc. In addition, it can also be used in electrochemical deposition and electroplating, and plays an important role in some electronic devices. Although it has no direct application in the medical field, it plays an important role in chemical research and industrial production.
    Tetrabutylammonium tetrafluoroborate
  • HY-400770
    MC-GGFG-AM-(10Me-11F-Camptothecin) intermediate-1

    1-(2-Amino-4-fluoro-5-methylphenyl)-2-chloroethanone

    		 Drug-Linker Conjugates for ADC Topoisomerase Cancer
    MC-GGFG-AM-(10Me-11F-Camptothecin) intermediate-1 (compound 19-2) is an intermediate for the synthesis of MC-GGFG-AM-(10Me-11F-Camptothecin) (HY-153360). Modifying groups can be added group. MC-GGFG-AM-(10Me-11F-Camptothecin) is a drug-linker conjugate used in the synthesis of ADCs .
    MC-GGFG-AM-(10Me-11F-Camptothecin) intermediate-1
  • HY-W012725
    2,4-Difluorophenol

    		Biochemical Assay Reagents Drug Intermediate Others
    2,4-Difluorophenol is a difluoro-substituted phenol that serves as a starting material for the synthesis of 4,6-difluoro-5,7-dihydroxytryptamine .
    2,4-Difluorophenol
  • HY-129650
    Florbetapir
    1 Publications Verification

    AV-45; Flobetapir

    		 Biochemical Assay Reagents Others
    Flobetapir (AV-45) may be a well-tolerated imaging agent. Flobetapir synthesizes Florbetapir (18F) that is a PET scanning radiopharmaceutical compound containing the radionuclide fluorine-18 .
    Florbetapir
  • HY-122607
    DPA-714

    		Mitochondrial Metabolism TSPO Inflammation/Immunology Cancer
    DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM), which is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. 18FDPA-714 successfully evaluates for the specific imaging of inflammation in various models of neuroinflammation and in a brain tumor model .
    DPA-714
  • HY-I0259
    8-Amino-2-naphthol

    		Fluorescent Dye Others
    8-Amino-2-naphthol is a photoactive charge transfer compounds, which can be used as fluorescent probe. 8-Amino-2-naphthol undergoes excited-state proton transfer (ESPT) to form a zwitterion under acidic conditions, where the photoacidity of its hydroxyl group is regulated by the protonation state of the amino group, enabling pH to act as an on/off switch for photoacidity. 8-Amino-2-naphthol is also utilized as chiral organocatalyst .
    8-Amino-2-naphthol
  • HY-W008598
    2-Bromo-4'-fluoroacetophenone

    p-Fluorophenacyl bromide

    		 DNA/RNA Synthesis Cancer
    2-Bromo-4'-fluoroacetophenone (p-Fluorophenacyl bromide) is a photoinducible DNA cleavage inducer.2-Bromo-4'-fluoroacetophenone generates fluorine-substituted phenyl radicals upon excitation and irradiation to cleave DNA, converting circular supercoiled DNA to circular relaxed and linear DNA forms.2-Bromo-4'-fluoroacetophenone exhibits concentration-dependent DNA cleaving activity.2-Bromo-4'-fluoroacetophenone can be used for the research of cancer .
    2-Bromo-4'-fluoroacetophenone
  • HY-119156
    Altanserin

    		5-HT Receptor Others
    Altanserin can synthesize Fluorine-18 Altanserin. Fluorine-18 Altanserin binds to the brain 5HT2 receptors .
    Altanserin
  • HY-P2496
    Endothelin 1 (swine, human), Alexa Fluor 488-labeled

    		Endothelin Receptor Cardiovascular Disease
    Endothelin 1 (swine, human), Alexa Fluor 488-labeled is a synthetic Endothelin 1 peptide labled with Alexa Fluor 488. Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ETA and ETB .
    Endothelin 1 (swine, human), Alexa Fluor 488-labeled
  • HY-130723A
    AMPK activator 2 hydrochloride

    		AMPK Cancer
    AMPK activator 2 (compound 7a) hydrochloride, a fluorine-containing proguanil derivative, up-regulates AMPK signal pathway and downregulates mTOR/4EBP1/p70S6K. AMPK activator 2 hydrochloride inhibits proliferation and migration of human cancer cell lines (UMUC3, T24, A549) .
    AMPK activator 2 hydrochloride
  • HY-76573
    ML-10

    		Apoptosis Cardiovascular Disease Cancer
    ML-10 is a small molecule apoptosis probe. Due to the presence of fluorine atoms, ML-10 can be radiolabeled with 18F isotopes and can be used for apoptosis positron emission tomography imaging studies. ML-10 is selectively taken up and accumulated in apoptotic cells, while being excluded from live or necrotic cells. In addition, the uptake of ML-10 is associated with apoptotic features such as caspase activation, Annexin-V binding, and disruption of mitochondrial membrane potential .
    ML-10
  • HY-152203
    Mitochondrial respiration-IN-2

    		Drug Derivative Cancer
    Mitochondrial respiration-IN-2 is the fluorine derivative of Virginiamycin M1 (HY-N6686). Mitochondrial respiration-IN-2 can inhibit mitochondrial translation of glioblastoma stem cells .
    Mitochondrial respiration-IN-2
  • HY-P11263
    AVLX-144

    		iGluR Neurological Disease
    AVLX-144 is a highly potent inhibitor of postsynaptic density protein 95 (PSD-95). AVLX-144 can be used as a template to develop imaging probes for postsynaptic density (PSD) molecules, and can be labeled with fluorine-18 (¹⁸F) or tritium (³H) to visualize PSD-95 in vivo. AVLX-144 can be utilized for the study of Parkinson's disease .
    AVLX-144
  • HY-W850994
    Tridecyl β-D-maltopyranoside

    Tridecyl beta-D-maltopyranoside

    		 Biochemical Assay Reagents Others
    Tridecyl β-D-maltopyranoside is a synthetic sugar, modified by fluorination and methylation. Carbohydrates can be used for the synthesis of glycosylated proteins (biosynth: W-204093).
    Tridecyl β-D-maltopyranoside
  • HY-40156
    5-Fluoroindole

    		Bacterial Reactive Oxygen Species (ROS) Apoptosis Infection
    5-Fluoroindole is an orally active fluorinated indole derivative and antibacterial agent. 5-Fluoroindole induces ROS accumulation and triggers Apoptosis. 5-Fluoroindole inhibits the growth of pan-susceptible Mycobacterium tuberculosis (Mtb) H37Rv strains. 5-Fluoroindole has significant bactericidal activity against Pseudomonas syringae pv. actinidiae (Psa) with an EC50 of 15.34 μg/mL. 5-Fluoroindole introduces fluorine labeling for protein research. 5-Fluoroindole can be used in the study of tuberculosis and kiwifruit bacterial canker .
    5-Fluoroindole
  • HY-101748
    Tegadifur

    40497S; FD 1

    		 Biochemical Assay Reagents Cancer
    Tegadifur is a fluorine-containing and anti-metabolic agent.
    Tegadifur
  • HY-155869
    5-fluoro-dCTP

    5-Fluoro-2′-deoxycytidine 5′-triphosphate

    		 DNA/RNA Synthesis Others
    5-fluoro-dCTP is a fluorinated pyrimidine dNTP that can be used as a substrate for the incorporation of fluorine modification into specific DNA sequences by primer extension (PEX) catalyzed by Pwo polymerase .
    5-fluoro-dCTP
  • HY-179227
    HDAC6 ligand-7

    		HDAC Neurological Disease
    HDAC6 ligand-7 (Compound 16a) is a positron emission tomography (PET) tracer for the deacetylase 6 (HDAC6) enzyme with a Kd value of 1.66 nM. HDAC6 ligand-7 exhibits excellent HDAC6 inhibitory activity, with IC50 values of 2.7 and 3.7 nM for hHDAC6 and mHDAC6, respectively, and has high selectivity for HDAC1/4/7/8. HDAC6 ligand-7 after being radioactively labeled with fluorine-18, [¹⁸F]HDAC6 ligand-7 shows varying degrees of radioactive uptake in PET, which can reflect the specific binding to HDAC6. HDAC6 ligand-7 can be used for the study of HDAC6 imaging .
    HDAC6 ligand-7
  • HY-W250129
    2,3,4,5-Tetrafluorobenzoyl chloride

    		Biochemical Assay Reagents Others
    2,3,4,5-Tetrafluorobenzoyl chloride is a fluorinated organic compound that belongs to the class of benzoyl chlorides. It is a colorless liquid with a pungent smell and is mainly used as an intermediate in the synthesis of various pharmaceutical and pesticide compounds. 2,3,4,5-Tetrafluorobenzoyl chloride is an acylating agent that can react with a variety of nucleophiles, including amines, alcohols, and thiols, to form amides, esters, or thioesters, respectively. Its unique fluorine-containing structure can impart desired properties to target molecules, such as increased lipophilicity or increased stability against metabolic degradation. However, due to its high reactivity and potential health hazards, proper safety measures and handling procedures must be followed when using this compound.
    2,3,4,5-Tetrafluorobenzoyl chloride
  • HY-W017590
    m-Fluoronitrobenzene

    1-Fluoro-3-nitrobenzene; 3-Fluoronitrobenzene; m-FNBZ

    		 Drug Derivative Others
    m-Fluoronitrobenzene (1-Fluoro-3-nitrobenzene) is a meta-substituted benzene derivative bearing fluoro and nitro functional groups. m-Fluoronitrobenzene finds applications in the fields of pharmaceuticals, dyes, pesticides, and synthetic rubber .
    m-Fluoronitrobenzene
  • HY-152202
    Mitochondrial respiration-IN-3

    		Mitochondrial Metabolism Cancer
    Mitochondrial respiration-IN-3 is the fluorine derivative of Dalfopristin (HY-A0241). Mitochondrial respiration-IN-3 has cell membrane-permeable. Mitochondrial respiration-IN-3 can inhibit mitochondrial translation of glioblastoma stem cells. Mitochondrial respiration-IN-3 can be used in research of cancer .
    Mitochondrial respiration-IN-3
  • HY-119156R
    Altanserin (Standard)

    		5-HT Receptor Others
    Altanserin (Standard) is the analytical standard of Altanserin. This product is intended for research and analytical applications. Altanserin can synthesize Fluorine-18 Altanserin. Fluorine-18 Altanserin binds to the brain 5HT2 receptors .
    Altanserin (Standard)
  • HY-123259
    CB3731

    		Thymidylate Synthase Others
    CB3731 is an analogue of N-10-(fluoroethyl)quinazolinylfolate and can be used for fluorine-19 nuclear magnetic resonance studies of binary and ternary complexes of thymidylate synthase .
    CB3731
  • HY-149926
    Cathepsin Inhibitor 3

    		Ser/Thr Protease Others
    Cathepsin Inhibitor 3 (Compound 53k) is a non-radioactive intermediate in compound [ 18F] 2k radioactive synthesis, which has selectivity for cathepsin S. Cathepsin Inhibitor 3 can undergo radioactive fluorination and can be used for fluorine-18 labeling research . Cathepsin Inhibitor 3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Cathepsin Inhibitor 3
  • HY-122607R
    DPA-714 (Standard)

    		Mitochondrial Metabolism Inflammation/Immunology Cancer
    DPA-714 (Standard) is the analytical standard of DPA-714. This product is intended for research and analytical applications. DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM), which is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. 18FDPA-714 successfully evaluates for the specific imaging of inflammation in various models of neuroinflammation and in a brain tumor model .
    DPA-714 (Standard)
  • HY-155869A
    5-fluoro-dCTP sodium

    5-Fluoro-2′-deoxycytidine 5′-triphosphate sodium

    		 DNA/RNA Synthesis Others
    5-fluoro-dCTP sodium is a fluorinated pyrimidine dNTP that can be used as a substrate for the incorporation of fluorine modification into specific DNA sequences by primer extension (PEX) catalyzed by Pwo polymerase .
    5-fluoro-dCTP sodium
  • HY-114253
    ODS-2004436

    		EGFR Cancer
    ODS-2004436 is a small molecule radiotracer that uses positron emission tomography (PET) imaging to measure the activity of the epidermal growth factor receptor (EGFR) in tumors. ODS-2004436 labeled with the radioactive isotope fluorine-18 shows significantly higher uptake in the xenograft models of lung cancer with EGFR mutations compared to the wild-type models, and could be used to distinguish the mutation status. ODS-2004436 can be used to identify EGFR-positive tumors and predict their response to certain reagent treatments, especially for non-small cell lung cancer (NSCLC) .
    ODS-2004436
  • HY-158317
    SFB-AMD3465

    		CXCR Biochemical Assay Reagents Others
    SFB-AMD3465 is an AMD3465 (HY-15971A) derivative. SFB-AMD3465 is utilized as positron emission tomography (PET) tracer for CXCR4, when labeled with radioactive Fluorine .
    SFB-AMD3465
  • HY-124287
    (Z)-1,2-Dimethoxy-4-(3-fluoro-2-propenyl)benzene

    		Insecticide Others
    (Z)-1,2-Dimethoxy-4-(3-fluoro-2-propenyl)benzene is a fluorine analog of Methyl eugenol (ME) and is attractive to oriental fruit fly B. dorsalis .
    (Z)-1,2-Dimethoxy-4-(3-fluoro-2-propenyl)benzene
  • HY-168061
    HldA/E-IN-1

    		Bacterial Infection
    HldA/E-IN-1 (compound 8) is a dual inhibitor of HldA/E, with IC50 values ​​of 17.2 μM and 67.8 μM for HldA/E, respectively. HldA/E-IN-1 can be used in the study of anti-bacterial infection .
    HldA/E-IN-1
  • HY-W458018
    Thalidomide-4-Br,7-F

    		Ligands for E3 Ligase Cancer
    Thalidomide-4-Br,7-F is an E3 ligase activator featuring a bromine and a fluorine. E3 ligase is a protein that marks other proteins for proteolytic destruction by labeling them with ubiquitin. Both halogens may be substituted for further derivitization.
    Thalidomide-4-Br,7-F
  • HY-W036734
    Tetrabutylammonium hydrogen difluoride

    		Biochemical Assay Reagents Others
    Tetrabutylammonium (hydrogen difluoride) is a quaternary ammonium salt containing fluoride ions. It is a highly active and effective reagent, often used in organic synthesis reactions, especially for the modification of organic molecules with fluorine atoms. Tetrabutylammonium (hydrogen difluoride) is also used as a catalyst for various chemical reactions such as esterification and transesterification. Additionally, it is used in the production of specialty chemicals such as surfactants and detergents.
    Tetrabutylammonium hydrogen difluoride
  • HY-149558
    CXCR4-IN-2

    		Apoptosis CXCR Cancer
    CXCR4-IN-2 (compound A1) is a bifunctional fluorinated small molecule that is a potent CXCR4 inhibitor with anticancer activity. CXCR4-IN-2 has cytotoxic (IC50: 60 μg/mL; 72 h) and antiproliferative effects on mouse colorectal cancer (CRC) cells. CXCR4-IN-2 induces cell arrest in the G2/M phase and induces apoptosis .
    CXCR4-IN-2
  • HY-155741
    CB2 PET Radioligand 1

    		Cannabinoid Receptor Neurological Disease
    CB2 PET Radioligand 1 (compound [18F]9) is a PET Radioligand targeting to hCB2 (Ki=7.7 nM). CB2 PET Radioligand 1 is prepared with Cu-mediated 18F-fluorination. CB2 PET Radioligand 1 shows high brain uptake in a murine model of neuroinflammation .
    CB2 PET Radioligand 1
  • HY-130723
    AMPK activator 2

    		AMPK Cancer
    AMPK activator 2 (compound 7a), a fluorine-containing proguanil derivative, up-regulates AMPK signal pathway and downregulates mTOR/4EBP1/p70S6K. AMPK activator 2 inhibits proliferation and migration of human cancer cell lines (UMUC3, T24, A549) .
    AMPK activator 2
  • HY-111654
    Diflucortolone

    		Glucocorticoid Receptor Metabolic Disease
    Diflucortolone is a fluorinated corticosteroid with fluorine atoms at the C6 and C9 positions .
    Diflucortolone
  • HY-180533
    Aldoview

    		Drug Intermediate Radionuclide-Drug Conjugates (RDCs) Endocrinology
    AldoView (Compound 3) is an intermediate. AldoView can be labeled with fluorine-18 to synthesize [ 18F]AldoView. [ 18F]AldoView is a highly selective aldosterone synthase PET imaging agent. AldoView can be used in imaging studies of primary aldosteronism .
    Aldoview
  • HY-180434
    GRPR antagonist-3

    		Bombesin Receptor Cancer
    GRPR antagonist-3 (compound (S)-1m) is a potent GRPR antagonist with an IC50 of 121 nM. GRPR antagonist-3 is stable in rat plasma and towards microsomal oxidative metabolism in vitro. GRPR antagonist-3 can be radiolabeled with fluorine-18 for PET imaging .
    GRPR antagonist-3
  • HY-W274282
    NSC 404988

    N,N-Diethyl-4-chlorobenzamide

    		 Biochemical Assay Reagents Others
    NSC 404988 (N,N-Diethyl-4-chlorobenzamide) is a cyclic acetal that can be used for the fluorination reaction .
    NSC 404988
  • HY-122607S
    DPA-714-d10

    		Isotope-Labeled Compounds Mitochondrial Metabolism TSPO Inflammation/Immunology Cancer
    DPA-714-d10 is the deuterium labeled DPA-714 (HY-122607). DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM), which is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. 18FDPA-714 successfully evaluates for the specific imaging of inflammation in various models of neuroinflammation and in a brain tumor model.
    DPA-714-d10
  • HY-W576868
    Thalidomide-4,5-F

    		Ligands for E3 Ligase Cancer
    Thalidomide-4,5-F is a fluorinated Thalidomide analogue. Thalidomide promotes the ubiquitinylation of proteins. The structure may be further derivatized via substitution at its fluorines.
    Thalidomide-4,5-F
  • HY-172295
    Tetrafluoro-thalidomide

    		Ligands for E3 Ligase Cancer
    Tetrafluoro-thalidomide is a fluorinated Thalidomide analogue. Tetrafluoro-thalidomide is an activator of E3 ligase, which ubiquitinylates proteins for later proteolysis. The structure may be further derivatized via substitution at its fluorines.
    Tetrafluoro-thalidomide
  • HY-W453715
    Thalidomide-4-F,5-Br

    		Ligands for E3 Ligase Cancer
    Thalidomide-4-F,5-Br is a Thalidomide analogue. Thalidomide recruits E3 ligase for the ubiquitinylation and subsequent proteolysis of a target protein. This molecule may be derivatized through substitution at fluorine or bromine.
    Thalidomide-4-F,5-Br
  • HY-W590575
    Azido-PEG3-flouride

    		Biochemical Assay Reagents Others
    Azido-PEG3-flouride is a PEG linker containing a fluorine atom and an azide group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.
    Azido-PEG3-flouride
  • HY-W586320
    Thalidomide-5-Br,6-F

    		Ligands for E3 Ligase Cancer
    Thalidomide-5-Br,6-F is a Thalidomide analogue. Thalidomide-5-Br,6-F is an activator of E3 ligase, which ubiquitinylates proteins for proteolysis. The structure may be further derivatized via substitution at fluorine or bromine.
    Thalidomide-5-Br,6-F
  • HY-106015
    Tezacitabine hydrate

    		DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Apoptosis Cancer
    Tezacitabine hydrate is a cytostatic and cytotoxic antimetabolite and nucleoside analogue. Tezacitabine hydrate irreversibly inhibits the ribonucleotide reductase and interferes with DNA replication and repair. Tezacitabine hydrate effectively induces cells Apoptosis. Tezacitabine hydrate has the potential for leukemias and solid tumors (carcinomas) treatment .
    Tezacitabine hydrate
  • HY-106014R
    Tezacitabine (Standard)

    		Reference Standards DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Apoptosis Cancer
    Tezacitabine (Standard) is the analytical standard of Tezacitabine (HY-106014). This product is intended for research and analytical applications. Tezacitabine is a cytostatic and cytotoxic antimetabolite and a nucleoside analogue. Tezacitabine irreversibly inhibits the ribonucleotide reductase and interferes with DNA replication and repair. Tezacitabine effectively induces cells apoptotic. Tezacitabine has the potential for leukemias and solid tumors (carcinomas) treatment .
    Tezacitabine (Standard)

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