2,4-Difluorophenol

Name: 2,4-Difluorophenol
Brand: MedChemExpress
SKU: HY-W012725
Rating: 4.5 (1 reviews)

Cat. No.: HY-W012725 Purity: 99.85%: Data Sheet
COA

SDS
Handling Instructions
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2,4-Difluorophenol is a difluoro-substituted phenol that serves as a starting material for the synthesis of 4,6-difluoro-5,7-dihydroxytryptamine.

For research use only. We do not sell to patients.

2,4-Difluorophenol Chemical Structure

CAS No. : 367-27-1

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
25 g	In-stock	Estimated Time of Arrival: December 31
100 g	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

2,4-Difluorophenol is a difluoro-substituted phenol that serves as a starting material for the synthesis of 4,6-difluoro-5,7-dihydroxytryptamine^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
MIA PaCa-2	IC₅₀	14758 nM Compound: S34, r1c11	Cytotoxicity against human MIA PaCa2 cells after 4 hrs by MTT assay Cytotoxicity against human MIA PaCa2 cells after 4 hrs by MTT assay	[PMID: 17944451]
MIA PaCa-2	IC₅₀	20772 nM Compound: S34, r1c11	Cytotoxicity against human MIA PaCa2 cells after 72 hrs by MTT assay Cytotoxicity against human MIA PaCa2 cells after 72 hrs by MTT assay	[PMID: 17944451]

In Vitro

2,4-Difluorophenol microwave spectroscopy and structural analysis confirm only the cis conformer is detectable, with defined rotational, centrifugal distortion, quadrupole coupling, and structural parameters, and an intramolecular hydrogen bond between the hydroxyl H-atom and a fluorine atom with a non-bonded distance of 2.23 Å^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

130.09

Formula

C₆H₄F₂O

CAS No.

367-27-1

Appearance

Solid

Color

Colorless to off-white

SMILES

OC1=CC=C(F)C=C1F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (768.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.6870 mL	38.4349 mL	76.8699 mL
5 mM	1.5374 mL	7.6870 mL	15.3740 mL
10 mM	0.7687 mL	3.8435 mL	7.6870 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.85%

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Data Sheet (270 KB) SDS (615 KB)

COA (247 KB) HNMR (118 KB) RP-HPLC (114 KB)

Handling Instructions (2659 KB)

References

[1]. K.P. Rajappan Nair, et al. Supersonic jet cooled rotational spectrum of 2,4-difluorophenol. Journal of Molecular Spectroscopy. Volume 335, May 2017, Pages 23-26.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	7.6870 mL	38.4349 mL	76.8699 mL	192.1747 mL
	5 mM	1.5374 mL	7.6870 mL	15.3740 mL	38.4349 mL
	10 mM	0.7687 mL	3.8435 mL	7.6870 mL	19.2175 mL
	15 mM	0.5125 mL	2.5623 mL	5.1247 mL	12.8116 mL
	20 mM	0.3843 mL	1.9217 mL	3.8435 mL	9.6087 mL
	25 mM	0.3075 mL	1.5374 mL	3.0748 mL	7.6870 mL
	30 mM	0.2562 mL	1.2812 mL	2.5623 mL	6.4058 mL
	40 mM	0.1922 mL	0.9609 mL	1.9217 mL	4.8044 mL
	50 mM	0.1537 mL	0.7687 mL	1.5374 mL	3.8435 mL
	60 mM	0.1281 mL	0.6406 mL	1.2812 mL	3.2029 mL
	80 mM	0.0961 mL	0.4804 mL	0.9609 mL	2.4022 mL
	100 mM	0.0769 mL	0.3843 mL	0.7687 mL	1.9217 mL