2. Apoptosis
  3. Apoptosis
  4. ML-10

ML-10 is a small molecule apoptosis probe. Due to the presence of fluorine atoms, ML-10 can be radiolabeled with 18F isotopes and can be used for apoptosis positron emission tomography imaging studies. ML-10 is selectively taken up and accumulated in apoptotic cells, while being excluded from live or necrotic cells. In addition, the uptake of ML-10 is associated with apoptotic features such as caspase activation, Annexin-V binding, and disruption of mitochondrial membrane potential.

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ML-10

ML-10 Chemical Structure

CAS No. : 1216897-16-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
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Based on 1 publication(s) in Google Scholar

ML-10 Related Antibodies

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Description

ML-10 is a small molecule apoptosis probe. Due to the presence of fluorine atoms, ML-10 can be radiolabeled with 18F isotopes and can be used for apoptosis positron emission tomography imaging studies. ML-10 is selectively taken up and accumulated in apoptotic cells, while being excluded from live or necrotic cells. In addition, the uptake of ML-10 is associated with apoptotic features such as caspase activation, Annexin-V binding, and disruption of mitochondrial membrane potential[1].

Clinical Trial
Molecular Weight

206.21

Formula

C9H15FO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C(C)(CCCCCF)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (484.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8494 mL 24.2471 mL 48.4943 mL
5 mM 0.9699 mL 4.8494 mL 9.6988 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.8494 mL 24.2471 mL 48.4943 mL 121.2356 mL
5 mM 0.9699 mL 4.8494 mL 9.6989 mL 24.2471 mL
10 mM 0.4849 mL 2.4247 mL 4.8494 mL 12.1236 mL
15 mM 0.3233 mL 1.6165 mL 3.2330 mL 8.0824 mL
20 mM 0.2425 mL 1.2124 mL 2.4247 mL 6.0618 mL
25 mM 0.1940 mL 0.9699 mL 1.9398 mL 4.8494 mL
30 mM 0.1616 mL 0.8082 mL 1.6165 mL 4.0412 mL
40 mM 0.1212 mL 0.6062 mL 1.2124 mL 3.0309 mL
50 mM 0.0970 mL 0.4849 mL 0.9699 mL 2.4247 mL
60 mM 0.0808 mL 0.4041 mL 0.8082 mL 2.0206 mL
80 mM 0.0606 mL 0.3031 mL 0.6062 mL 1.5154 mL
100 mM 0.0485 mL 0.2425 mL 0.4849 mL 1.2124 mL
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ML-10 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ML-101216897-16-3ML10ML 10ApoptosisRadiolabelingPositive emission tomography imagingmembrane potentialInhibitorinhibitorinhibit

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