DMT-2′Fluoro-dU Phosphoramidite (Synonyms: 2'-F-dU Phosphoramidite)

Cat. No.: HY-45409 Purity: 98.83%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

DMT-2′Fluoro-dU Phosphoramidite could be used for nucleoside modification.

For research use only. We do not sell to patients.

DMT-2′Fluoro-dU Phosphoramidite Chemical Structure

CAS No. : 146954-75-8

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
1 g	USD 25	In-stock	Estimated Time of Arrival: December 31
5 g	USD 81	In-stock	Estimated Time of Arrival: December 31
10 g	USD 145	In-stock	Estimated Time of Arrival: December 31
50 g		Get quote

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Description

DMT-2′Fluoro-dU Phosphoramidite could be used for nucleoside modification.

Molecular Weight

748.78

Formula

C₃₉H₄₆FN₄O₈P

CAS No.

146954-75-8

Appearance

Solid

Color

White to yellow

SMILES

F[C@@H]1[C@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@@H](COC(C2=CC=C(OC)C=C2)(C3=CC=C(OC)C=C3)C4=CC=CC=C4)O[C@H]1N5C(NC(C=C5)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (133.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3355 mL	6.6775 mL	13.3551 mL
5 mM	0.2671 mL	1.3355 mL	2.6710 mL
10 mM	0.1336 mL	0.6678 mL	1.3355 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.34 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (3.34 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.83%

Select Batch:

Data Sheet (250 KB) SDS (393 KB)

COA (262 KB) HNMR (325 KB) LCMS (112 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3355 mL	6.6775 mL	13.3551 mL	33.3876 mL
	5 mM	0.2671 mL	1.3355 mL	2.6710 mL	6.6775 mL
	10 mM	0.1336 mL	0.6678 mL	1.3355 mL	3.3388 mL
	15 mM	0.0890 mL	0.4452 mL	0.8903 mL	2.2258 mL
	20 mM	0.0668 mL	0.3339 mL	0.6678 mL	1.6694 mL
	25 mM	0.0534 mL	0.2671 mL	0.5342 mL	1.3355 mL
	30 mM	0.0445 mL	0.2226 mL	0.4452 mL	1.1129 mL
	40 mM	0.0334 mL	0.1669 mL	0.3339 mL	0.8347 mL
	50 mM	0.0267 mL	0.1336 mL	0.2671 mL	0.6678 mL
	60 mM	0.0223 mL	0.1113 mL	0.2226 mL	0.5565 mL
	80 mM	0.0167 mL	0.0835 mL	0.1669 mL	0.4173 mL
	100 mM	0.0134 mL	0.0668 mL	0.1336 mL	0.3339 mL

DMT-2′Fluoro-dU Phosphoramidite Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DMT-2′Fluoro-dU Phosphoramidite146954-75-82'-F-dU PhosphoramiditeNucleoside Antimetabolite/AnalogInhibitorinhibitorinhibit

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