2'-OMe-G(ibu) Phosphoramidite
Based on 1 Customer Validation
2'-OMe-G(ibu) Phosphoramidite (DMT-2'-O-Methyl-rG(ib) Phosphoramidite) is a modified phosphoramidite monomer that can be used for the oligonucleotide synthesis.
For research use only. We do not sell to patients.
- Purity: 99.42%
- CAS No.: 150780-67-9
- Formula: C45H56N7O9P
- Molecular Weight:869.94
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-138580
2'-OMe-A(Bz) Phosphoramidite
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HY-W101391
DMT-2'O-Methyl-rU Phosphoramidite
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HY-45491
Dmt-2'-f-dc(ac) amidite
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HY-45492
DMT-2'Fluoro-DG(IB) Amidite
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HY-138577
2'-F-Bz-dC Phosphoramidite
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HY-138586
DMT-dC(ac) Phosphoramidite
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HY-138585
DMT-dG(dmf) Phosphoramidite
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HY-21648
2'-OMe-Ac-C Phosphoramidite
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HY-21997
DMT-2'fluoro-da(bz) amidite
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HY-104014
DMT-2'O-MOE-rG(ib) Phosphoramidite
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HY-W570885
2'-O-MOE-rC
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HY-138578
2'-O-Me-C(Bz) Phosphoramidite
Biological Activity
2'-OMe-G(ibu) Phosphoramidite as a solid support under standard conditions usually applied in DNA and 2’-OMe RNA synthesis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 150780-67-9
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Appearance Solid
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Molecular Weight 869.94
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Formula C45H56N7O9P
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Color White to light yellow
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SMILES
COC(C=C1)=CC=C1C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@@H]4[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](OC)[C@H](N5C(N=C(NC(C(C)C)=O)NC6=O)=C6N=C5)O4
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Synonyms
DMT-2'-O-Methyl-rG(ib) Phosphoramidite
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (114.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (2.87 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1495 mL | 5.7475 mL | 11.4950 mL | 28.7376 mL |
| 5 mM | 0.2299 mL | 1.1495 mL | 2.2990 mL | 5.7475 mL | |
| 10 mM | 0.1150 mL | 0.5748 mL | 1.1495 mL | 2.8738 mL | |
| 15 mM | 0.0766 mL | 0.3832 mL | 0.7663 mL | 1.9158 mL | |
| 20 mM | 0.0575 mL | 0.2874 mL | 0.5748 mL | 1.4369 mL | |
| 25 mM | 0.0460 mL | 0.2299 mL | 0.4598 mL | 1.1495 mL | |
| 30 mM | 0.0383 mL | 0.1916 mL | 0.3832 mL | 0.9579 mL | |
| 40 mM | 0.0287 mL | 0.1437 mL | 0.2874 mL | 0.7184 mL | |
| 50 mM | 0.0230 mL | 0.1150 mL | 0.2299 mL | 0.5748 mL | |
| 60 mM | 0.0192 mL | 0.0958 mL | 0.1916 mL | 0.4790 mL | |
| 80 mM | 0.0144 mL | 0.0718 mL | 0.1437 mL | 0.3592 mL | |
| 100 mM | 0.0115 mL | 0.0575 mL | 0.1150 mL | 0.2874 mL |
2'-OMe-G(ibu) Phosphoramidite Related Classifications
HY-138579 Related Classifications
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