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  3. Phosphoramidites DNA/RNA Synthesis Nucleoside Antimetabolite/Analog
  4. 2'-F-Bz-dC Phosphoramidite

2'-F-Bz-dC Phosphoramidite can be used in the synthesis of oligoribonucleotide (such as DNA and RNA). 2'-F-Bz-dC Phosphoramidite also used for synthesis antiviral agent to inhibit the replication of virus. 2'-F-Bz-dC Phosphoramidite contains a phosphorothioate backbone, to synthesise antisense oligonucleotide analogs to induce apoptosis in cancer cells.

For research use only. We do not sell to patients.

2'-F-Bz-dC Phosphoramidite

2'-F-Bz-dC Phosphoramidite Chemical Structure

CAS No. : 161442-19-9

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Based on 1 publication(s) in Google Scholar

2'-F-Bz-dC Phosphoramidite Related Antibodies

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Description

2'-F-Bz-dC Phosphoramidite can be used in the synthesis of oligoribonucleotide (such as DNA and RNA). 2'-F-Bz-dC Phosphoramidite also used for synthesis antiviral agent to inhibit the replication of virus. 2'-F-Bz-dC Phosphoramidite contains a phosphorothioate backbone, to synthesise antisense oligonucleotide analogs to induce apoptosis in cancer cells[1][2][3].

In Vitro

Oligonucleotides are a class of short-chain nucleic acids composed of deoxyribonucleotides or ribonucleotides; by adhering to the principle of complementary base pairing, they can pair with DNA, mRNA, or pre-mRNA to precisely "silence" specific genes, thereby inhibiting the expression of numerous proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2'-F-Bz-dC Phosphoramidite Related Antibodies
Molecular Weight

851.90

Formula

C46H51FN5O8P
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

COC1=CC=C(C(C2=CC=C(OC)C=C2)(OC[C@@H]3[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](F)[C@H](N4C=CC(NC(C5=CC=CC=C5)=O)=NC4=O)O3)C6=CC=CC=C6)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (117.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1738 mL 5.8692 mL 11.7385 mL
5 mM 0.2348 mL 1.1738 mL 2.3477 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 5 mg/mL (5.87 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.48%

SDS (419 KB)

COA (262 KB) HNMR (323 KB) RP-HPLC (263 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1738 mL 5.8692 mL 11.7385 mL 29.3462 mL
5 mM 0.2348 mL 1.1738 mL 2.3477 mL 5.8692 mL
10 mM 0.1174 mL 0.5869 mL 1.1738 mL 2.9346 mL
15 mM 0.0783 mL 0.3913 mL 0.7826 mL 1.9564 mL
20 mM 0.0587 mL 0.2935 mL 0.5869 mL 1.4673 mL
25 mM 0.0470 mL 0.2348 mL 0.4695 mL 1.1738 mL
30 mM 0.0391 mL 0.1956 mL 0.3913 mL 0.9782 mL
40 mM 0.0293 mL 0.1467 mL 0.2935 mL 0.7337 mL
50 mM 0.0235 mL 0.1174 mL 0.2348 mL 0.5869 mL
60 mM 0.0196 mL 0.0978 mL 0.1956 mL 0.4891 mL
80 mM 0.0147 mL 0.0734 mL 0.1467 mL 0.3668 mL
100 mM 0.0117 mL 0.0587 mL 0.1174 mL 0.2935 mL
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2'-F-Bz-dC Phosphoramidite Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2'-F-Bz-dC Phosphoramidite161442-19-9PhosphoramiditesDNA/RNA SynthesisNucleoside Antimetabolite/AnalogInhibitorinhibitorinhibit

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