DMT-2'Fluoro-DG(IB) Amidite
Based on 1 Customer Validation
DMT-2'Fluoro-DG(IB) Amidite (2'-F-ibu-dG Phosphoramidite) is a nucleoside that can be employed for oligonucleotide synthesis. DMT-2'Fluoro-DG(IB) Amidite can be used to prepare 4'-modified 2'-deoxy-2'-fluorouridine.
For research use only. We do not sell to patients.
- Purity: 98.00%
- CAS No.: 144089-97-4
- Formula: C44H53FN7O8P
- Molecular Weight:857.91
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
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Biological Activity
DMT-2'Fluoro-DG(IB) Amidite is a modified nucleoside phosphoramidite with a fluorine on the 2' position and can be employed for oligonucleotide synthesis.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 144089-97-4
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Appearance Solid
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Molecular Weight 857.91
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Formula C44H53FN7O8P
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Color White to off-white
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SMILES
COC(C=C1)=CC=C1C(C2=CC=C(C=C2)OC)(C3=CC=CC=C3)OC[C@@H]4[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](F)[C@H](N5C=NC6=C5NC(NC(C(C)C)=O)=NC6=O)O4
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Synonyms
2'-F-ibu-dG Phosphoramidite
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (116.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (282 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1656 mL | 5.8281 mL | 11.6562 mL | 29.1406 mL |
| 5 mM | 0.2331 mL | 1.1656 mL | 2.3312 mL | 5.8281 mL | |
| 10 mM | 0.1166 mL | 0.5828 mL | 1.1656 mL | 2.9141 mL | |
| 15 mM | 0.0777 mL | 0.3885 mL | 0.7771 mL | 1.9427 mL | |
| 20 mM | 0.0583 mL | 0.2914 mL | 0.5828 mL | 1.4570 mL | |
| 25 mM | 0.0466 mL | 0.2331 mL | 0.4662 mL | 1.1656 mL | |
| 30 mM | 0.0389 mL | 0.1943 mL | 0.3885 mL | 0.9714 mL | |
| 40 mM | 0.0291 mL | 0.1457 mL | 0.2914 mL | 0.7285 mL | |
| 50 mM | 0.0233 mL | 0.1166 mL | 0.2331 mL | 0.5828 mL | |
| 60 mM | 0.0194 mL | 0.0971 mL | 0.1943 mL | 0.4857 mL | |
| 80 mM | 0.0146 mL | 0.0729 mL | 0.1457 mL | 0.3643 mL | |
| 100 mM | 0.0117 mL | 0.0583 mL | 0.1166 mL | 0.2914 mL |
DMT-2'Fluoro-DG(IB) Amidite Related Classifications
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