399-52-0
Chemical Structure
5-Fluoroindole
- CAS No.: 399-52-0
- Formula:C8H6FN
- Molecular Weight:135.14
IUPAC Name: 5-fluoro-1H-indole
InChIKey: ODFFPRGJZRXNHZ-UHFFFAOYSA-N
SMILES: FC1=CC=C2NC=CC2=C1
Biological Activity: 5-Fluoroindole is an orally active fluorinated indole derivative and antibacterial agent. 5-Fluoroindole induces ROS accumulation and triggers Apoptosis. 5-Fluoroindole inhibits the growth of pan-susceptible Mycobacterium tuberculosis (Mtb) H37Rv strains. 5-Fluoroindole has significant bactericidal activity against Pseudomonas syringae pv. actinidiae (Psa) with an EC50 of 15.34 μg/mL. 5-Fluoroindole introduces fluorine labeling for protein research. 5-Fluoroindole can be used in the study of tuberculosis and kiwifruit bacterial canker[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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5-Fluoroindole | 99.88% | 5-Fluoroindole is an orally active fluorinated indole derivative and antibacterial agent. 5-Fluoroindole induces ROS accumulation and triggers Apoptosis. 5-Fluoroindole inhibits the growth of pan-susceptible Mycobacterium tuberculosis (Mtb) H37Rv strains. 5-Fluoroindole has significant bactericidal activity against Pseudomonas syringae pv. actinidiae (Psa) with an EC50 of 15.34 μg/mL. 5-Fluoroindole introduces fluorine labeling for protein research. 5-Fluoroindole can be used in the study of tuberculosis and kiwifruit bacterial canker. | ||||||||||||||||||||
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References
- [1]. Neves CE, et al., 5-Fluoroindole Reduces the Bacterial Burden in a Murine Model of Mycobacterium tuberculosis Infection. ACS Omega. 2024 Jul 16;9(30):32969-32979. [Content Brief]
- [2]. Zhang C, et al. 5-Fluoroindole Inhibits Its Putative Target Methionine Synthase and Pseudomonas syringae pv. actinidiae Virulence. J Agric Food Chem. 2025 Jul 2;73(26):16193-16204. [Content Brief]
- [3]. Pan B, et al. Fluorine-19 labeling of the tryptophan residues in the G protein-coupled receptor NK1R using the 5-fluoroindole precursor in Pichia pastoris expression. J Biomol NMR. 2024 Sep;78(3):133-138. [Content Brief]
