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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
hemichannel
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "hemichannel" in MCE Product Catalog:
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Carbenoxolone is a blood-brain barrier-permeable Pannexin1 inhibitor, gap junction (Gap junction) blocker, and β-amyloid 42 inhibitor. Carbenoxolone modulates voltage-gated currents of wild-type and mutant Panx1, and inhibits stimulus-activated Panx1 channel function. Carbenoxolone interacts with stable residues of β-amyloid 42 peptides, fibrils and oligomers, thereby inhibiting their aggregation. Carbenoxolone alleviates liver fibrosis. Carbenoxolone exerts neuroprotective and nootropic effects. Carbenoxolone can be used in studies related to Alzheimer's disease and liver fibrosis .
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5 Cited Publications
Cat. No.: HY-P1136
CAS No.: 1507930-57-5
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5 Cited Publications
Cat. No.: HY-P1136A
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2
2 Cited Publications
Cat. No.: HY-P1136B
CAS No.: 1507930-54-2
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2 Cited Publications
Cat. No.: HY-P1136C
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Scrambled 10Panx (FSVYWAQADR) is an inactive scrambled control peptide of the Pannexin-1 hemichannel inhibitory peptide 10panx .
Cat. No.: HY-P10849
CAS No.: 3061802-23-8
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Cat. No.: HY-B1588S
Cat. No.: HY-P992010
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Cat. No.: HY-167983
CAS No.: 1840896-10-7
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Cx43 HC-IN-1 (Compound D4) is a selective and orally active inhibitor of connexin hemichannels (Cx43 HC). Cx43 HC-IN-1 effectively inhibits the hemichannel activity mediated by Cx43/Cx45 in denervated skeletal muscle fibers, significantly increasing the reinnervation rate of muscle fibers by neurons. Cx43 HC-IN-1 reduces neuroinflammation and neuronal overexcitation by inhibiting hemichannels in glial cells in the brain, and alleviates epilepsy in mice. Cx43 HC-IN-1 can be used for research on epilepsy and muscle diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
