Search Result

Results for "

human CD38

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CD38 (15) LAG-3 (1) Tim3 (1) ADC Antibody (2) Apoptosis (1) Fc Receptor (FcR) (1) PD-1/PD-L1 (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (1) Inflammation/Immunology (7) Metabolic Disease (2) Neurological Disease (3)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Oligonucleotides

Targets Recommended: CD38 CD1 CD28 CD19 CD20 CD22 Transferrin Receptor CD3 P-selectin CD6 CD2 CD276/B7-H3 CD73 c-Kit LAG-3 L-Selectin CTLA-4 CD47 ALCAM/CD166 Neprilysin E-Selectin Scavenger Receptor Class B type I (SR-BI） FLT3 Tim3 CD44 Anaplastic lymphoma kinase (ALK) CD74 Human leukocyte immunoglobulin (Ig)-like receptors (LILR) P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P9915

Daratumumab 10+ Cited Publications Anti-human CD38, human Antibody; HuMax-CD38; JNJ-54767414	CD38 ADC Antibody	Inflammation/Immunology Cancer
Daratumumab (Anti-Human CD38) is the first-in-class human-specific *anti-CD38* monoclonal antibody (IgG1). Daratumumab has anti-multiple myeloma (MM) effect. Daratumumab impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition .

HY-P9915A

Daratumumab (Anti-CD38) 10+ Cited Publications Anti-human CD38, human Antibody (PBS)	ADC Antibody CD38	Cancer
Daratumumab (PBS) (Anti-Human CD38) is the first-in-class human-specific *anti-CD38* monoclonal antibody (IgG1). Daratumumab (PBS) has anti-multiple myeloma (MM) effect. Daratumumab (PBS) impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition .

HY-P99616

Felzartamab MOR-202	CD38	Cancer
Felzartamab (MOR-202) is a human monoclonal antibody that targets *CD38* and can be used in multiple myeloma research .

HY-150508

MK-0159 1 Publications Verification	CD38	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
MK-0159 is an orally active, potent and selective *CD38* inhibitor, with IC₅₀ values of 22, 3, and 70 nM for human, mouse and rat CD38, respectively. MK-0159 also shows good microsomal stability for human and rodent liver microsomes. MK-0159 increases NAD ⁺ (nicotinamide adenine dinucleotide) and reduces ADPR (adenosine diphosphate ribose) in whole blood and heart .

HY-144987

RBN013209 1 Publications Verification	CD38 LAG-3 Tim3 PD-1/PD-L1	Inflammation/Immunology Cancer
RBN013209 is an orally active small molecule inhibitor of *CD38* with an IC₅₀ of 0.01 to 0.1 μM for human CD38. RBN013209 prevents the conversion of extracellular NAD ⁺ to ADPR or cADPR in tumor cells and PBMCs. RBN013209 can be used in the study of tumor. In addition, RBN013209 enables CAR-T cells to maintain the naive state and central memory state, and decreases the expression of cell activation markers and exhaustion-related inhibitory receptors .

HY-P990747

Lumrotatug CM-313	CD38	Inflammation/Immunology
Lumrotatug is an anti-CD38 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-RS02239

CD38 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CD38 Human Pre-designed siRNA Set A contains three designed siRNAs for CD38 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CD38 Human Pre-designed siRNA Set A CD38 Human Pre-designed siRNA Set A

HY-P991461

AMG-424 XmAb968	CD38	Cancer
AMG-424 (XmAb968) is a human bispecific antibody (bsAb) targeting CD38 & CD3E. AMG-424 kills CD38-expressing cancer cells, triggers T-cell proliferation and attenuates cytokine release. AMG 424 has antitumor activity in a bone marrow-invasive mouse cancer model and induces peripheral B-cell depletion in cynomolgus monkeys. AMG-424 can be used in multiple myeloma research. Recommended isotype control: half-IG G1-kappa/(scFv-heavy-lambda)-h-CH2-CH3 .

HY-P991715

Sanritatug SG-301	CD38	Inflammation/Immunology
Sanritatug is an anti-CD38 IgG1κ antibody, with its corresponding isotype control being Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991462

GBR-1342	CD38	Cancer
GBR-1342 is a human bispecific antibody (bsAb) targeting CD38 & CD3. GBR-1342 inhibits the activity of Daudi, RAJI, RPMI8226, IM-9, and NCI-H929 cancer cell lines. GBR-1342 can be used in myeloma research .

HY-184021

A-8531	CD38	Neurological Disease
A-8531 is an orally active *CD38* inhibitor with IC₅₀ values of 1.10 nM against human CD38, IC₅₀ values of 2.93 nM against mouse CD38, and a human K_a of 0.32 nM. A-8531 exerts its inhibitory activity via its 4-pyridine reactive warhead interacting with the CD38 substrate NAD ⁺, and binds stably to CD38 only in the presence of NAD ⁺, with a binding K_D of 0.32 nM as detected by SPR. A-8531 dose-dependently increases NAD ⁺ levels in mouse skin, lung and liver tissues, while simultaneously reducing the contents of NAM and ADPR in these tissues. A-8531 derivative A-3190 (HY-184206) has blood-brain barrier penetration. A-8531 can be used in studies related to neurodegenerative diseases .

HY-182345

NOTA-MK0159	CD38	Cancer
NOTA-MK0159 is a NOTA (HY-134418) and MK0159 (HY-150508) conjugate. NOTA-MK0159 inhibits human and mouse *CD38* with IC₅₀ values of 72.58 and 7.55 nM. NOTA-MK0159 coupled with radioactive elements acts as a imaging agent with specific uptake in CD38-positive multiple myeloma cells, enabling noninvasive whole-body assessment of CD38 expression in multiple myeloma xenografts. NOTA-MK0159 can be used for the research of multiple myeloma .

HY-181543

CVN14	CD38	Neurological Disease
CVN14 is a potent, selective and brain-penetrant *CD38* inhibitor with human IC₅₀ 19 nM, mouse IC₅₀ 2.4 nM. CVN14 binds uncompetitively to form a complex with *CD38* and ADPR, and inhibits *CD38* enzymatic activity. CVN14 can be used for the research of neurodegenerative diseases .

HY-P992455

SAR442085	CD38 Fc Receptor (FcR) Apoptosis	Cancer
SAR442085 is an Fc-engineered anti-CD38 monoclonal antibody with a K_d of 0.2 nM for human CD38. SAR442085 inhibits CD38, induces apoptosis, and triggers antibody-dependent cellular cytotoxicity and phagocytosis in CD38-expressing tumor cells. SAR442085 binds allelic variants of FcγRIIa and FcγRIIIa, enhances NK cell activation, degranulation and cytokine secretion, and exerts anti-tumor activity in human Fc receptor transgenic mice. SAR442085 can be used in the research of multiple myeloma .

HY-184206

A-3190	CD38	Neurological Disease Inflammation/Immunology
A-3190 is an orally active, blood-brain barrier permeable *CD38* inhibitor, with an IC₅₀ of 7.25 nM against human CD38 and 1.24 nM against mouse CD38. A-3190 is a derivative of A-8531 (HY-184021), and it forms covalent adducts with NAD ⁺ in the presence of CD38. A-3190 acts as an inducer of NAD ⁺ levels and an inhibitor of NAM and ADPR levels. A-3190 increases NAD ⁺ levels in the skin, lung, liver and brain of rodents, while reducing NAM and ADPR levels in brain tissues. A-3190 can be used in research related to multiple sclerosis, Parkinson's disease and Alzheimer's disease .

HY-186178

CD38-IN-6	CD38	Metabolic Disease Inflammation/Immunology
CD38-IN-6 is an orally active CD38 inhibitor. CD38-IN-6 regulates NAD ⁺ metabolite levels in the liver of aged obese mice by increasing NAD ⁺ and NMN levels, and decreasing NAM and ADPR levels. CD38-IN-6 alleviates inflammatory responses in mice. CD38-IN-6 can be used for research related to obesity and inflammation .

Cat. No.	Product Name	Target	Research Area	Image

HY-P9915

Daratumumab 10+ Cited Publications Anti-human CD38, human Antibody; HuMax-CD38; JNJ-54767414	CD38 ADC Antibody	Inflammation/Immunology Cancer
Daratumumab (Anti-Human CD38) is the first-in-class human-specific *anti-CD38* monoclonal antibody (IgG1). Daratumumab has anti-multiple myeloma (MM) effect. Daratumumab impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition .

HY-P9915A

Daratumumab (Anti-CD38) 10+ Cited Publications Anti-human CD38, human Antibody (PBS)	ADC Antibody CD38	Cancer
Daratumumab (PBS) (Anti-Human CD38) is the first-in-class human-specific *anti-CD38* monoclonal antibody (IgG1). Daratumumab (PBS) has anti-multiple myeloma (MM) effect. Daratumumab (PBS) impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition .

HY-P99616

Felzartamab MOR-202	CD38	Cancer
Felzartamab (MOR-202) is a human monoclonal antibody that targets *CD38* and can be used in multiple myeloma research .

HY-P990747

Lumrotatug CM-313	CD38	Inflammation/Immunology
Lumrotatug is an anti-CD38 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991461

AMG-424 XmAb968	CD38	Cancer
AMG-424 (XmAb968) is a human bispecific antibody (bsAb) targeting CD38 & CD3E. AMG-424 kills CD38-expressing cancer cells, triggers T-cell proliferation and attenuates cytokine release. AMG 424 has antitumor activity in a bone marrow-invasive mouse cancer model and induces peripheral B-cell depletion in cynomolgus monkeys. AMG-424 can be used in multiple myeloma research. Recommended isotype control: half-IG G1-kappa/(scFv-heavy-lambda)-h-CH2-CH3 .

HY-P991715

Sanritatug SG-301	CD38	Inflammation/Immunology
Sanritatug is an anti-CD38 IgG1κ antibody, with its corresponding isotype control being Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991462

GBR-1342	CD38	Cancer
GBR-1342 is a human bispecific antibody (bsAb) targeting CD38 & CD3. GBR-1342 inhibits the activity of Daudi, RAJI, RPMI8226, IM-9, and NCI-H929 cancer cell lines. GBR-1342 can be used in myeloma research .

HY-P992455

SAR442085	CD38 Fc Receptor (FcR) Apoptosis	Cancer
SAR442085 is an Fc-engineered anti-CD38 monoclonal antibody with a K_d of 0.2 nM for human CD38. SAR442085 inhibits CD38, induces apoptosis, and triggers antibody-dependent cellular cytotoxicity and phagocytosis in CD38-expressing tumor cells. SAR442085 binds allelic variants of FcγRIIa and FcγRIIIa, enhances NK cell activation, degranulation and cytokine secretion, and exerts anti-tumor activity in human Fc receptor transgenic mice. SAR442085 can be used in the research of multiple myeloma .

Species:	Human (11)
Tag:	His (7) Avi (2) Flag (1) Fc (4)
Source:	HEK293 (11)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70731A

	CD38 Protein, Human (HEK293, His) ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADP-ribosyl cyclase 1; Cyclic ADP-ribose hydrolase 1; CD38 antigen; CD38 molecule; CD38	Human	HEK293
	The CD38 protein plays a key role in cell signaling, proficiently synthesizing cyclic ADP-ribose (cADPR) as a critical second messenger for glucose-induced insulin secretion. It also promotes the synthesis of the calcium mobilizer niacin-adenine dinucleotide phosphate (NAADP+). CD38 Protein, Human (HEK293, His) is the recombinant human-derived CD38 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P78650

	*FITC-Labeled CD38* Protein, Human (HEK293, His)** CD38; T10; cADPr hydrolase 1	Human	HEK293
	The CD38 protein plays a key role in cell signaling, proficiently synthesizing cyclic ADP-ribose (cADPR) as a critical second messenger for glucose-induced insulin secretion. It also promotes the synthesis of the calcium mobilizer niacin-adenine dinucleotide phosphate (NAADP+). FITC-Labeled CD38 Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled CD38 protein, expressed by HEK293 , with C-His labeled tag.

HY-P701286

	*FITC-Labeled CD38* Protein, Human (HEK293, Fc)** CD38; T10; cADPr hydrolase 1	Human	HEK293
	The CD38 protein plays a key role in cell signaling, proficiently synthesizing cyclic ADP-ribose (cADPR) as a critical second messenger for glucose-induced insulin secretion. It also promotes the synthesis of the calcium mobilizer niacin-adenine dinucleotide phosphate (NAADP+). FITC-Labeled CD38 Protein, Human (HEK293, Fc) is the recombinant human-derived FITC-Labeled CD38 protein, expressed by HEK293 , with Fc labeled tag.

HY-P70731

	CD38 Protein, Human (HEK293, His, solution) ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADP-ribosyl cyclase 1; Cyclic ADP-ribose hydrolase 1; CD38 antigen; CD38 molecule; CD38	Human	HEK293
	The CD38 protein plays a key role in cell signaling, proficiently synthesizing cyclic ADP-ribose (cADPR) as a critical second messenger for glucose-induced insulin secretion. It also promotes the synthesis of the calcium mobilizer niacin-adenine dinucleotide phosphate (NAADP+). CD38 Protein, Human (HEK293, His, solution) is the recombinant human-derived CD38 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70022

	CD38 Protein, Human (HEK293, Fc) rHuADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, Fc; ADP-ribosyl cyclase 1; cyclic ADP-ribose hydrolase; CD38; T10	Human	HEK293
	The CD38 protein plays a key role in cell signaling, proficiently synthesizing cyclic ADP-ribose (cADPR) as a critical second messenger for glucose-induced insulin secretion. It also promotes the synthesis of the calcium mobilizer niacin-adenine dinucleotide phosphate (NAADP+). CD38 Protein, Human (HEK293, Fc) is the recombinant human-derived CD38 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P70892

	IL-17RA Protein, Human (HEK293, His) ADP-ribosyl cyclase 1; cyclic ADP-ribose hydrolase; CD38; T10	Human	HEK293
	IL-17RA (Interleukin 17 receptor A), a receptor for IL-17A and IL-17F, is a type I membrane glycoprotein. It is expressed ubiquitously and exhibits a broad tissue distribution, and plays a role in many inflammatory and autoimmune diseases. IL-17RA is a common co-receptor subunit for other members of the IL-17 family. IL-17RA associates with IL-17RC to form a signaling receptor complex for IL-17A and IL-17F. IL-17RA Protein, Human (HEK293, His) is produced in HEK293 cells with six C-Terminal His-tags.

HY-P704467

	CD38-Serum Albumin Protein, Human (HEK293, His) rHuADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, Fc; ADP-ribosyl cyclase 1; cyclic ADP-ribose hydrolase; CD38; T10	Human	HEK293

HY-P704262

	CD38 Protein, Human (HEK293, mFc) VISTA; B7-H5; Platelet receptor Gi24; Stress-induced secreted protein-1; Sisp-1; C10orf54; SISP1	Human	HEK293
	The CD38 protein plays a key role in cell signaling, proficiently synthesizing cyclic ADP-ribose (cADPR) as a critical second messenger for glucose-induced insulin secretion. It also promotes the synthesis of the calcium mobilizer niacin-adenine dinucleotide phosphate (NAADP+). CD38 Protein, Human (HEK293, mFc) is the recombinant human-derived CD38 protein, expressed by HEK293, with C-mFc labeled tag.

HY-P704942

	CD38 Protein, Human (HEK293, His-Flag) ADP-ribosyl cyclase1; 2'-phospho-ADP-ribosyl cyclase; ADP-ribosyl cyclase 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1	Human	HEK293

HY-P72356

	CD38 Protein, Human (Biotinylated, HEK293, His-Avi) ADP-ribosyl cyclase1; 2'-phospho-ADP-ribosyl cyclase; ADP-ribosyl cyclase 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1	Human	HEK293
	The CD38 protein plays a key role in cell signaling, proficiently synthesizing cyclic ADP-ribose (cADPR) as a critical second messenger for glucose-induced insulin secretion. It also promotes the synthesis of the calcium mobilizer niacin-adenine dinucleotide phosphate (NAADP+). CD38 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD38 protein, expressed by HEK293 , with N-Avi, N-6*His labeled tag.

HY-P704994

	CD38 Protein, Human (Biotinylated, HEK293, Fc-Avi) ADP-ribosyl cyclase1; 2'-phospho-ADP-ribosyl cyclase; ADP-ribosyl cyclase 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1	Human	HEK293

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

CD38 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CD38 Human Pre-designed siRNA Set A contains three designed siRNAs for CD38 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: