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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
human TrkA
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "human TrkA" in MCE Product Catalog:
1
Target:
Research Areas:
PF-06273340 is a peripherally restricted pan-Trk inhibitor with IC50 values of 6, 4, 3 nM for TrkA, TrkB, and TrkC receptors. PF-06273340 binds in a DFG-out conformation, targeting less conserved kinase ligand binding domain regions outside the ATP binding pocket. PF-06273340 exhibits anti-hyperalgesic and analgesic effects. PF-06273340 can be used for the research of pain .
Target:
Serotonin Transporter 5-HT Receptor Histamine Receptor mAChR Adrenergic Receptor Sodium Channel Trk Receptor
Research Areas:
Amitriptyline-d3 hydrochloride is the deuterium labeled Amitriptyline (hydrochloride). Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity .
Cat. No.: HY-E70869
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TRKA (also named NTRK1) is a potential new member of the tyrosine kinase gene family. TRKA is a receptor tyrosine kinase that is phosphorylated in response to NGF. A single transmembrane domain divides TRKA into an extracellular domain, important for NGF binding, and an intracellular tyrosine kinase domain, important for signal transduction. TRKA(NTRK1) Recombinant Human Active Protein Kinase is a recombinant TRKA(NTRK1) protein that can be used to study TRKA(NTRK1)-related functions .
Cat. No.: HY-P991622
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Research Areas:
Cat. No.: HY-E70785
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Research Areas:
TRKA is a member of the tropomyosin receptor kinase (TRK) family, and its primary binding ligand is nerve growth factor (NGF). TRKA G667C is a mutant of TRKA. TRKA G667C Recombinant Human Active Protein Kinase is a recombinant TRKA G667C protein that can be used to study TRKA G667C-related functions .
Cat. No.: HY-P991323
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Cat. No.: HY-P990589
Synonyms: BXL-1H5
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Cat. No.: HY-176942
CAS No.: 2644645-39-4
Synonyms: ROS1-IN-3
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JYP0322 (ROS1-IN-3) is a potent orally active, selective, and CNS-penetrant ROS1 inhibitor. JYP0322 selectively inhibits human wild-type ROS1 and human ROS1 G2032R with IC50s of 0.37 and 0.3 nM, respectively, showing 6-130-fold selectivity over TRKA, TRKB, and TRKC. JYP0322 inhibits proliferation of ROS1 fusion-expressing cells, and inhibits tumor growth in mouse xenograft models. JYP0322 can be used for the research of non-small cell lung cancer (NSCLC) .
Cat. No.: HY-P992345
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Cat. No.: HY-P11480
CAS No.: 3105660-96-3
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Cat. No.: HY-153501
CAS No.: 1377503-70-2
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TrkA-IN-5 is a TrkA inhibitor with an IC50 value of 1.678 nM against TrkA. TrkA-IN-5 can be used in cancer research .
Cat. No.: HY-181780
CAS No.: 2489327-91-3
Target:
Research Areas:
TRK-IN-34 is an orally active TRKand TRKC mutant kinase inhibitor, with IC50 values of 0.75 nM and 0.96 nM against TRKA G595R and TRKA G667C, respectively. TRK-IN-34 inhibits the kinase activities of TRKA G595R and TRKA G667C at the functional level. TRK-IN-34 inhibits the proliferation of TRKA-transfected cells, exerts tumor growth-inhibitory effects and achieves partial tumor regression in xenograft models. TRK-IN-34 can be used to study TRK inhibitor-resistant cancers driven by the TRKA G667C mutation .
Cat. No.: HY-P704311
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHuTrkA; NTRK1; MTC; TRK
Cat. No.: HY-P705892
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; NTRK-1; NTRK1; Slow nerve growth factor receptor; p140-TrkA; Trk-A; Trk; TrkA; TRK1-transforming tyrosine kinase protein; TrkAOncogene TRK; TRKTRK1; tyrosine kinase receptor A
Species:
Source:
Cat. No.: HY-P706108
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A; Trk-A; gp140trk; p140-TrkA; MTC; TRK; TrkA
Species:
Source:
Cat. No.: HY-P702762
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; NTRK-1; NTRK1; Slow nerve growth factor receptor; p140-TrkA; Trk-A; Trk; TrkA; TRK1-transforming tyrosine kinase protein; TrkAOncogene TRK; TRKTRK1; tyrosine kinase receptor A
Species:
Source:
Cat. No.: HY-P704941
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHuTrkA; NTRK1; MTC; TRK
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
