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Cat. No.: HY-153501

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TrkA-IN-5

TrkA-IN-5 is a TrkA inhibitor with an IC₅₀ value of 1.678 nM against TrkA. TrkA-IN-5 can be used in cancer research.

For research use only. We do not sell to patients.

CAS No.: 1377503-70-2
Formula: C₂₅H₁₈F₃N₅O₂S
Molecular Weight:509.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

TrkA-IN-5 Chemical Structure

CAS No.: 1377503-70-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

TrkA-IN-5 is a TrkA inhibitor with an IC₅₀ value of 1.678 nM against TrkA. TrkA-IN-5 can be used in cancer research^[1].

IC₅₀ & Target^[1]

TrkA

1.678 nM (IC₅₀)

All Trk Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	GI	40 % Compound: 6t	Cytotoxicity against human MCF7 cells assessed as growth inhibition at 0.1 to 50 uM after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as growth inhibition at 0.1 to 50 uM after 48 hrs by MTT assay	[PMID: 22575050]
MCF7	IC₅₀	4.2 μM Compound: 6t	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 22575050]

In Vitro

TrkA-IN-5 (Compound 20) potently inhibits human TrkA (PDB ID: 4aoj) with an IC₅₀ value of 1.678 nM. It forms multiple stable hydrogen bonds and hydrophobic interactions with the active site of this protein, and its activity can be accurately predicted by CoMFA and CoMSIA 3D-QSAR models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1377503-70-2
Molecular Weight 509.51
Formula C₂₅H₁₈F₃N₅O₂S
SMILES

O=S(=O)(NC1=CC(N)=CC(=C1)C2=CN=C3NC=C(C=4C=CN=CC4)C3=C2)C=5C=CC=C(C5)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Adnane Aouidate, et al. Molecular Docking and 3D-QSAR Studies on 7-azaindole Derivatives as
Inhibitors of Trk A: A Strategic Design in Novel Anticancer Agents. Letters in Drug Design & Discovery, 2018, 15, 1211-1223.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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