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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
hyphal morphology
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "hyphal morphology" in MCE Product Catalog:
Filastatin is a long-lasting inhibitor of Candida albicans filamentation. Filastatin inhibits adhesion by multiple pathogenic Candida species with an IC50 of ~3 μM in the GFP-based adhesion assay. Filastatin inhibits fungal adhesion to polystyrene and human cells, the yeast-to-hyphal morphological transition, induction of the hyphal-specific HWP1 promoter. Filastatin has potent antifungal effect .
Cat. No.: HY-P10304A
Synonyms: Cyclo(Pro-Arg) TFA
Cat. No.: HY-N2558
CAS No.: 19668-69-0
Category:
Murraya paniculata (L.) Jack. Rutaceae Coumarins Phenylpropanoids Plants Disease Research Fields Cancer
Target:
Cat. No.: HY-172777
CAS No.: 3052432-15-9
Research Areas:
SDH-IN-25 is a succinate dehydrogenase (SDH) inhibitor (IC50 = 4.82 mg/L). SDH-IN-25 exhibited broad-spectrum and potent antifungal activity. SDH-IN-25 mimics the interaction pattern of commercial fungicide Fluxapyroxad (HY-135549) through binding to SDH amino acid residues (TRP173, TYR58, and ARG43). SDH-IN-25 can induce hyphal morphology, interfere with respiratory metabolism by binding to complex II, generate reactive oxygen species (ROS), and affect mitochondrial membrane potential (MMP) in mycelia. SDH-IN-25 can be studied in research for agricultural disease control .
Cat. No.: HY-184308
CAS No.: 3123321-73-0
Target:
Research Areas:
Antifungal agent-165 is an antifungal agent with in vitro activity against Rhizoctonia solani. Antifungal agent-165 inhibits catalase (CAT) activity, drives intracellular ROS accumulation, and induces oxidative damage. Antifungal agent-165 disrupts fungal hyphal morphology, compromises cell membrane integrity, and triggers cellular content leakage in Rhizoctonia solani. Antifungal agent-165 can be used for the research of potato black scurf disease .
Cat. No.: HY-187437
CAS No.: 3133348-60-1
Target:
Research Areas:
CYP51-IN-33 is a CYP51 inhibitor with an IC50 of 0.35 μM against the sterol 14α-demethylase activity of Rhizoctonia solani CYP51. CYP51-IN-33 interferes with CYP51-associated ergosterol biosynthesis, accompanied by changes in hyphal morphology, increased membrane permeability and intracellular ROS accumulation. CYP51-IN-33 can be used in studies on CYP51-targeted antifungal activity and rice sheath blight .
Cat. No.: HY-183333
CAS No.: 3094676-22-6
CHNQD-02204 is a potent and selective antifungal agent with in vitro activity against Candida albicans, with a MIC of 0.025 μg/mL. CHNQD-02204 inhibits ergosterol biosynthesis, disrupts the membrane integrity and biofilm formation of Candida albicans, and suppresses the morphological transition of Candida albicans from yeast to hyphal form. CHNQD-02204 can be used in studies related to candidal infections .
Cat. No.: HY-184420
CAS No.: 1822599-86-9
Research Areas:
Antimicrobial agent-51 is an antifungal agent that increases ROS levels, reduces mitochondrial membrane potential, alters hyphal morphology, and impairs cell membrane integrity. Antimicrobial agent-51 inhibits succinate dehydrogenase (SDH) with an IC50 of 0.76 μg/mL against Colletotrichum gloeosporioides. Antimicrobial agent-51 exhibits control efficacy against Alternaria solani on tomato fruits and shows low toxicity to plant and mammalian cells. Antimicrobial agent-51 can be used for the research of plant fungal diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
