Antifungal agent-165

Antifungal agent-165 (Compound 5b) (50 μg/mL; 4-7 days) shows broad-spectrum in vitro antifungal activity against nine plant pathogenic fungal strains, including potent 89.9% inhibition of Rhizoctonia solani at 50 μg/mL^[1].
Antifungal agent-165 (6.25-100 μg/mL; 5 days) potently inhibits Rhizoctonia solani mycelial growth with an IC₅₀ of 3.9 μg/mL^[1].
Antifungal agent-165 (6.25-50 μg/mL; 10 h) dose-dependently increases cell membrane permeability in Rhizoctonia solani^[1].
Antifungal agent-165 (6.25-50 μg/mL; 24 h) dose-dependently induces leakage of intracellular nucleic acids and proteins from Rhizoctonia solani mycelia, with absorbance values doubling at 25 μg/mL compared to controls^[1].
Antifungal agent-165 (25-50 μg/mL; 24 h) dose-dependently disrupts the morphological integrity of Rhizoctonia solani hyphae^[1].
Antifungal agent-165 (25-50 μg/mL; 12 h) dose-dependently compromises Rhizoctonia solani cell membrane integrity, as shown by increased propidium iodide uptake at higher concentrations^[1].
Antifungal agent-165 (10-50 μg/mL; 36 h) dose-dependently reduces superoxide dismutase and catalase activity while increasing malondialdehyde levels in Rhizoctonia solani, indicating induction of oxidative stress^[1].

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