Antifungal agent-165 

Antifungal agent-165 is an antifungal agent with in vitro activity against Rhizoctonia solani. Antifungal agent-165 inhibits catalase (CAT) activity, drives intracellular ROS accumulation, and induces oxidative damage. Antifungal agent-165 disrupts fungal hyphal morphology, compromises cell membrane integrity, and triggers cellular content leakage in Rhizoctonia solani. Antifungal agent-165 can be used for the research of potato black scurf disease^[1].

Antifungal agent-165 (Compound 5b) (50 μg/mL; 4-7 days) shows broad-spectrum in vitro antifungal activity against nine plant pathogenic fungal strains, including potent 89.9% inhibition of Rhizoctonia solani at 50 μg/mL^[1].
Antifungal agent-165 (6.25-100 μg/mL; 5 days) potently inhibits Rhizoctonia solani mycelial growth with an IC₅₀ of 3.9 μg/mL^[1].
Antifungal agent-165 (6.25-50 μg/mL; 10 h) dose-dependently increases cell membrane permeability in Rhizoctonia solani^[1].
Antifungal agent-165 (6.25-50 μg/mL; 24 h) dose-dependently induces leakage of intracellular nucleic acids and proteins from Rhizoctonia solani mycelia, with absorbance values doubling at 25 μg/mL compared to controls^[1].
Antifungal agent-165 (25-50 μg/mL; 24 h) dose-dependently disrupts the morphological integrity of Rhizoctonia solani hyphae^[1].
Antifungal agent-165 (25-50 μg/mL; 12 h) dose-dependently compromises Rhizoctonia solani cell membrane integrity, as shown by increased propidium iodide uptake at higher concentrations^[1].
Antifungal agent-165 (10-50 μg/mL; 36 h) dose-dependently reduces superoxide dismutase and catalase activity while increasing malondialdehyde levels in Rhizoctonia solani, indicating induction of oxidative stress^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

311.37

C₁₉H₂₁NO₃

3123321-73-0

C=CC(C)(C)C1=CC(/C=C/C(C2=CC=CN2)=O)=C(OC)C=C1O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Tian T, et al.. Design, synthesis, and antifungal activity of licochalcone A derivatives and mechanism of action against Phytopathogenic Fungi. Bioorganic chemistry. 2026 Sep 05;179:110004.