2 Results for "

iNOS/ICAM-1

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "iNOS/ICAM-1" in MCE Product Catalog:

Casuarinin
Casuarinin
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Cat. No.: HY-N12717
CAS No.: 79786-01-9
Category:  

Terminalia arjuna (Roxb. ex DC.) Wight & Arn. Combretaceae Phenols Polyphenols Plants

Target:  

PAK FASTK HSP p38 MAPK NF-κB NO Synthase COX HSV Caspase TNF Receptor Fungal Apoptosis

Casuarinin is an orally active antiproliferative, anti-inflammatory, antifungal, virucidal and gastroprotective agent. Casuarinin upregulates the expression of p21/WAF1, Fas/APO‑1, mFasL, sFasL and HSP‑70, arrests cell cycle, induces apoptosis and inhibits cancer cell proliferation. Casuarinin inhibits TNF‑α-induced phosphorylation of MAPK and activation of NF‑κB, downregulates the expression of iNOS, NF‑κB, COX‑2 and ICAM‑1, and reduces the production of proinflammatory mediators. Casuarinin attenuates ethanol-induced activation of caspase‑3 and elevation of TNF‑α, inhibits the growth of Candida albicans, and inhibits HSV‑2. Casuarinin can be used in research related to mammary adenocarcinoma, inflammatory skin diseases, gastric ulcers, candidiasis and herpes simplex virus infections .
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Aloenin aglycone
Aloenin aglycone
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Cat. No.: HY-N11996
CAS No.: 59163-53-0
Category:  

Liliaceae Aloe vera (L.) Burm. f. Phenols Polyphenols Plants

Target:  

NO Synthase NF-κB

Aloenin aglycone (compound 13) is an NF-κB inhibitor that can be isolated from aloe exudate. Aloenin aglycone inhibits TNFα-induced NF-κB transcriptional activity (IC50: 18.7 μM). Aloenin aglycone (10 μM) also reduced inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) gene expression after treatment of HepG2 cells with 10 ng/mL TNFα .
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