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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

immune cell labeling

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (3) Androgen Receptor (1) Apoptosis (9) Autophagy (1) Bacterial (7) Bcl-2 Family (1) Biochemical Assay Reagents (5) Caspase (1) Cholinesterase (ChE) (1) COX (1) DNA/RNA Synthesis (1) Drug Metabolite (2) Endogenous Metabolite (19) Enterovirus (1) Estrogen Receptor/ERR (1) Fluorescent Dye (1) Fungal (1) G protein-coupled Bile Acid Receptor 1 (2) Herbicide (1) Histamine Receptor (4) Insecticide (2) Interleukin Related (1) Isotope-Labeled Compounds (30) MHC (1) MMP (1) nAChR (1) NOD-like Receptor (NLR) (1) p38 MAPK (3) Reactive Oxygen Species (ROS) (5) ROR (1) Thrombopoietin Receptor (1) Topoisomerase (1) VD/VDR (1) Virus Protease (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (5) Endocrinology (3) Infection (8) Inflammation/Immunology (16) Metabolic Disease (11) Neurological Disease (5)

By Targets:

Akt (3)

Androgen Receptor (1)

Apoptosis (9)

Autophagy (1)

Bacterial (7)

Bcl-2 Family (1)

Biochemical Assay Reagents (5)

Caspase (1)

Cholinesterase (ChE) (1)

COX (1)

DNA/RNA Synthesis (1)

Drug Metabolite (2)

Endogenous Metabolite (19)

Enterovirus (1)

Estrogen Receptor/ERR (1)

Fluorescent Dye (1)

Fungal (1)

G protein-coupled Bile Acid Receptor 1 (2)

Herbicide (1)

Histamine Receptor (4)

Insecticide (2)

Interleukin Related (1)

Isotope-Labeled Compounds (30)

MHC (1)

MMP (1)

nAChR (1)

NOD-like Receptor (NLR) (1)

p38 MAPK (3)

Reactive Oxygen Species (ROS) (5)

ROR (1)

Thrombopoietin Receptor (1)

Topoisomerase (1)

VD/VDR (1)

Virus Protease (1)

By Research Areas:

Cancer (8)

Cardiovascular Disease (5)

Endocrinology (3)

Infection (8)

Inflammation/Immunology (16)

Metabolic Disease (11)

Neurological Disease (5)

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Isotope-Labeled Compounds

Targets Recommended: Programmed Cell Death 4 (PDCD4) Itk TOPK NAMPT ALCAM/CD166 GDNF Receptor BCL6 Tim3 VISTA BMI1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112624I

Dextran T3 (MW 3,000) Dextran 3; Dextran D3; Dextran T3(MW 2400-3600)	Bacterial	Others
Dextran T3 (Dextran 3; Dextran T3(MW 2400-3600)) is a neural tracer and intestinal permeability probe that can move anterogradely and retrogradely in neuronal axons by passive diffusion. Dextran T3 (MW 3,000) is able to permeate across the intestinal epithelial cell membrane in the presence of cholera toxin-induced cytoskeletal disturbance. Dextran T3 (MW 3,000) is used as a fluorescent marker to rapidly label developing neurons (such as Xenopus retinal ganglion cells) and to assess intestinal barrier function. It can be used to study axonal transport in neuroanatomy and permeability changes in intestinal pathophysiology. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance .

HY-B2176S

ATP-13C10,15N5 Adenosine 5'-triphosphate-¹³C₁₀,¹⁵N₅	Endogenous Metabolite	Metabolic Disease
ATP- ¹³C₁₀, ¹⁵N₅ is the ¹³C and ¹⁵N labeled ATP . ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation .

HY-B2176S6

ATP-13C10 dilithium Adenosine 5'-triphosphate-13C10 dilithium	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
ATP- ¹³C₁₀ (Adenosine 5'-triphosphate- ¹³C₁₀) dilithium is ¹³C-labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.

HY-B2176S5

ATP-15N5 dilithium Adenosine 5'-triphosphate-15N5 dilithium	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
ATP- ¹⁵N₅ (Adenosine 5'-triphosphate- ¹⁵N₅) dilithium is ¹⁵N labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.

HY-B1946S

Dimethoate-d6	Isotope-Labeled Compounds Insecticide Reactive Oxygen Species (ROS) Apoptosis Cholinesterase (ChE)	Inflammation/Immunology
Dimethoate-d₆ is the deuterium labeled Dimethoate. Dimethoate is an organophosphate insecticide and acaricide. Dimethoate is an orally active acetylcholinesterase inhibitor. Dimethoate induces reactive oxygen species (ROS). Dimethoate induces DNA damage and cell apoptosis in vivo. Dimethoate affect immune system in mice .

HY-B0345AS

ATP-18O4 sodium	Endogenous Metabolite	Metabolic Disease
ATP- ¹⁸O₄ (disodium salt) is the ¹⁸O labeled ATP disodium salt . ATP disodium salt (Adenosine 5'-triphosphate disodium salt) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt is an important endogenous signaling molecule in immunity and inflammation .

HY-W014375S4

DL-Arginine-13C6,15N4 hydrochloride (±)-Arginine-13C6,15N4 hydrochloride	Isotope-Labeled Compounds Endogenous Metabolite	Cardiovascular Disease
DL-Arginine- ¹³C₆, ¹⁵N₄ hydrochloride is ¹³C and ¹⁵N-labeled DL-Arginine hydrochloride (HY-W014375). DL-Arginine ((±)-Arginine) hydrochloride is the racemic compound of L-Arginine (HY-N0455) and D-Arginine (HY-W016781). Arginine is an essential amino acid that requires additional supplementation in traumatic or diseased conditions. Arginine is involved in T cell activation, proliferation, and differentiation, and affects the function of immune cells .

HY-B2176S4

ATP-d14 dilithium Adenosine 5'-triphosphate-d14 dilithium	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
ATP-d₁₄ (Adenosine 5'-triphosphate-d₁₄) dilithium is deuterium labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.

HY-B2176S7

ATP-13C2 dilithium Adenosine 5'-triphosphate-13C2 dilithium	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
ATP- ¹³C₂ (Adenosine 5'-triphosphate- ¹³C₂) dilithium is ¹³C-labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.

HY-W010243S

Methylisothiazolinone-d3 hydrochloride	Isotope-Labeled Compounds Bacterial MMP Apoptosis Fungal	Infection Inflammation/Immunology
Methylisothiazolinone-d₃ hydrochloride is the deuterium labeled Methylisothiazolinone hydrochloride (HY-W010243). Methylisothiazolinone hydrochloride is a bacterial and fungal inhibitor and preservative, as well as a sensitizer. Methylisothiazolinone hydrochloride can activate matrix metalloproteinases (MMPs) in human bronchial epithelial cells to induce apoptosis and inflammatory response. Methylisothiazolinone hydrochloride can promote the development of atopic dermatitis in mice by disrupting Th2/Th17 related immune responses. Methylisothiazolinone hydrochloride can cause mitochondrial damage in the endothelium of rat cerebral blood vessels .

HY-150709S1

Adenosine 5'-triphosphate-13C10,15N5 dilithium	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
Adenosine 5'-triphosphate-13C10,15N5 dilithium is 13C and 15N labeled dilithium salt form of Adenosine 5'-triphosphate (HY-B2176). Adenosine 5'-triphosphate is a central component of energy storage and metabolism in vivo. Adenosine 5'-triphosphate provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. Adenosine 5'-triphosphate is an important endogenous signaling molecule in immunity and inflammation .

HY-N0349S1

Methyl paraben-13C6 Methyl 4-hydroxybenzoate-¹³C₆	Isotope-Labeled Compounds Bacterial Endogenous Metabolite	Infection
Methyl Paraben- ¹³C₆ (Methyl 4-hydroxybenzoate- ¹³C₆) is a ¹³C labeled Methyl Paraben (HY-N0349) . Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, agents and cosmetics. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity .

HY-B1204S1

Histamine-d4 Ergamine-d₄	Isotope-Labeled Compounds Histamine Receptor p38 MAPK Akt Reactive Oxygen Species (ROS) Apoptosis Endogenous Metabolite	Neurological Disease Inflammation/Immunology Endocrinology Cancer
Histamine-d₄ (Ergamine-d₄) is deuterium labeled Histamine (HY-B1204). Histamine is the agonist for histamine receptor and a vasodilator. Histamine is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. Histamine affects p38 MAPK/Akt signaling pathway, exhibits antitumor, antioxidant and anti-inflammatory activities. Histamine can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma .

HY-D2396

Sulfo SMCC R-phycoerythrin Sulfo SMCC R-PE	Fluorescent Dye	Cancer
Sulfo SMCC R-phycoerythrin is a conjugate composed of the protein crosslinker SMCC (HY-42360) and R-PE (R-Phycoerythrin) (HY-D0988) that can be used to label proteins to make them carry red fluorescence. Among them, SMCC is able to engage antigen-coupled spleen cells to induce antigen-specific immune responses .

HY-114364S

UDP-α-D-Galactose-13C disodium	Isotope-Labeled Compounds	Others
UDP-α-D-Galactose- ¹³C disodium is the ¹³C labeled UDP-α-D-Galactose disodium. UDP-Galactose disodium is a monosaccharide and a key glycosyl donor molecule in cells that participates in nucleotide sugar metabolism. UDP-Galactose disodium is the natural agonist of the P2Y₁₄ receptor coupled to G_i proteins in the immune system (IC₅₀= 0.67 μM, hP2Y₁₄). UDP-Galactose disodium can be used to study cell signal transduction and substance metabolism .

HY-15306S

Eltrombopag-13C4 1 Publications Verification SB-497115-¹³C₄	Thrombopoietin Receptor Bacterial Apoptosis	Infection Cardiovascular Disease Cancer
Eltrombopag- ¹³C₄ (SB-497115- ¹³C₄) is ^{13 sup>C-labeled Z-Eltrombopag. Z-Eltrombopag is an orally active thrombopoietin-receptor non-peptide agonist with platelet-stimulating activity for the study of chronic immune thrombocytopenia. Eltrombopag also has strong inhibitory effects on multidrug-resistant Staphylococcus aureus (Staphylococcus aureus) and can induce apoptosis (apoptosis) in liver cancer cells .}

HY-143712S1

Allolithocholic Acid-d4 3α-hydoxy-5α-Cholaoic Acid-d4, allo-LCA-d₄	Isotope-Labeled Compounds Drug Metabolite G protein-coupled Bile Acid Receptor 1 ROR	Metabolic Disease Inflammation/Immunology Cancer
Allolithocholic Acid-d₄ (3α-hydoxy-5α-Cholaoic Acid-d₄, allo-LCA-d₄) is deuterium labeled Allolithocholic acid (HY-143712). Allolithocholic acid is an orally active metabolite of Lithocholic acid (HY-B0172). Allolithocholic acid is a dual GPBAR1 agonist (EC₅₀ = 2.7 μM) and RORγt inverse agonist (IC₅₀ = 3.4 μM). Allolithocholic acid modulates immune and metabolic pathways, regulates immune cell polarization, prevents M1 macrophage and Th17 CD4 cell polarization. Allolithocholic acid improves insulin sensitivity, reduces liver lipid accumulation, reverses liver immunological, inflammatory and metabolic signaling dysregulation, restores bile acid homeostasis, adipose tissue histopathology/function, and intestinal microbiota composition, modulates intestinal immunity. Allolithocholic acid can be used for the researches of cancer, inflammayion, immunology and metabolic disease .

HY-N0349S

Methyl paraben-d4 Methyl 4-hydroxybenzoate-d₄	Bacterial Endogenous Metabolite	Infection
Methyl paraben-d₄ is the deuterium labeled Methyl Paraben . Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, agents and cosmetics. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity .

HY-W653896

Alternariol-d2	Isotope-Labeled Compounds Androgen Receptor Apoptosis Topoisomerase Estrogen Receptor/ERR	Infection
Alternariol-d₂ is deuterium labeled Alternariol. Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects .

HY-B1204S2

Histamine-13C5, 15N3 Ergamine-¹³C₅, ¹⁵N₃	Isotope-Labeled Compounds Histamine Receptor p38 MAPK Akt Reactive Oxygen Species (ROS) Apoptosis Endogenous Metabolite	Neurological Disease Inflammation/Immunology Endocrinology Cancer
Histamine- ¹³C₅, ¹⁵N₃ (Ergamine- ¹³C₅, ¹⁵N₃) is the ¹³C and ¹⁵N labeled isotope of Histamine (HY-B1204). Histamine is the agonist for histamine receptor and a vasodilator. Histamine is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. Histamine affects p38 MAPK/Akt signaling pathway, exhibits antitumor, antioxidant and anti-inflammatory activities. Histamine can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma .

HY-W739948

Naltrexone-d3	Isotope-Labeled Compounds	Others
Naltrexone-d₃ is a deuterated labeled Naltrexone (HY-76711) . Naltrexone is an antagonist of Opioid receptor. Naltrexone inhibits cell proliferation in vivo. Naltrexone reduces tumor growth by interfering with cell signalling and modifying the immune system .

HY-B2046S

Simazine-d10	Isotope-Labeled Compounds Herbicide Apoptosis Reactive Oxygen Species (ROS) Bcl-2 Family Caspase	Inflammation/Immunology
Simazine-d₁₀ is the deuterium labeled Simazine (HY-B2046). Simazine is a triazine herbicide. Simazine is widely used in agriculture, potted plant and tree production. In addition, Simazine can induce the apoptosis of immune cells in the spleen of mice and inhibit the proliferation of B cells and T cells in mice .

HY-N6746S1

Citrinin-13C13 NSC 186-¹³C₁₃	Isotope-Labeled Compounds Apoptosis Bacterial Autophagy	Infection Neurological Disease Cancer
Citrinin- ¹³C₁₃ (NSC 186- ¹³C₁₃) is the ¹³C labeled Citrinin (HY-N6746). Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .

HY-W014375S3

DL-Arginine-d7 hydrochloride (±)-Arginine-d7 hydrochloride	Isotope-Labeled Compounds Endogenous Metabolite	Cardiovascular Disease
DL-Arginine-d₇ hydrochloride is deuterium labeled DL-Arginine hydrochloride (HY-W014375). DL-Arginine ((±)-Arginine) hydrochloride is the racemic compound of L-Arginine (HY-N0455) and D-Arginine (HY-W016781). Arginine is an essential amino acid that requires additional supplementation in traumatic or diseased conditions. Arginine is involved in T cell activation, proliferation, and differentiation, and affects the function of immune cells .

HY-158471

Core 1 O-glycan (C1)	Biochemical Assay Reagents	Others
Core 1 O-glycan (C1) is an important O-linked glycan with core structure 1 (MUC1-M). Core 1 O-glycan (C1), 2AB labeled is related to sialylation and participates in life activities including cell recognition, protection, immune regulation and disease markers .

HY-W014375S

DL-Arginine-15N4,d7 hydrochloride (±)-Arginine-15N4,d7 hydrochloride	Isotope-Labeled Compounds Endogenous Metabolite	Cardiovascular Disease
DL-Arginine- ¹⁵N₄,d₇ hydrochloride is deuterium and ¹⁵N labeled DL-Arginine hydrochloride (HY-W014375). DL-Arginine ((±)-Arginine) hydrochloride is the racemic compound of L-Arginine (HY-N0455) and D-Arginine (HY-W016781). Arginine is an essential amino acid that requires additional supplementation in traumatic or diseased conditions. Arginine is involved in T cell activation, proliferation, and differentiation, and affects the function of immune cells .

HY-158470

Disialylated Core 2 O-glycan (C2S(3,3)2), 2-AB labelled	Biochemical Assay Reagents	Others
Disialylated Core 2 O-glycan (C2S(3,3)2), 2-AB labeled is a 2-AB (2-aminobenzamide) labeled O-linked glycan with core structure 2. Disialylated Core 2 O-glycan (C2S(3,3)2), 2-AB labeled is related to sialylation and participates in life activities including cell recognition, protection, immune regulation and disease markers .

HY-124356AS

Alcaftadine carboxylic acid-d3 sodium	Isotope-Labeled Compounds Histamine Receptor	Inflammation/Immunology
Alcaftadine carboxylic acid-d₃ (sodium) is deuterium labeled Alcaftadine carboxylic acid. Alcaftadine carboxylic acid is a broad-spectrum antihistamine compound with high affinity for histamine H1 and H2 receptors and low affinity for H4 receptors. Alcaftadine carboxylic acid has also demonstrated effects on modulating immune cell recruitment and stabilizing mast cells. Alcaftadine carboxylic acid is more effective than placebo in preventing ocular itching associated with allergic conjunctivitis and is at least as effective as olopatadine 0.01% .

HY-W014375S1

DL-Arginine-13C6,15N4,d7 hydrochloride (±)-Arginine-13C6,15N4,d7 hydrochloride	Isotope-Labeled Compounds Endogenous Metabolite	Cardiovascular Disease
DL-Arginine- ¹³C₆, ¹⁵N₄,d₇ hydrochloride is ¹³C and ¹⁵N-labeled DL-Arginine hydrochloride (HY-W014375). DL-Arginine ((±)-Arginine) hydrochloride is the racemic compound of L-Arginine (HY-N0455) and D-Arginine (HY-W016781). Arginine is an essential amino acid that requires additional supplementation in traumatic or diseased conditions. Arginine is involved in T cell activation, proliferation, and differentiation, and affects the function of immune cells .

HY-106161S1

Rupintrivir-d7 AG7088-d₇	Isotope-Labeled Compounds Enterovirus Virus Protease	Infection
Rupintrivir-d7 is a deuterated labeled Rupintrivir . Rupintrivirvr (AG7088), an antiviral agent, is a potent, selective and irreversible inhibitor of human rhinovirus (HRV) 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays, with a mean EC₅₀ of 0.023 μM. Rupintrivirvr shows immune-modulatory effect .

HY-B1204S4

Histamine-15N3 Ergamine-¹⁵N₃	Isotope-Labeled Compounds Histamine Receptor p38 MAPK Akt Reactive Oxygen Species (ROS) Apoptosis Endogenous Metabolite	Neurological Disease Inflammation/Immunology Endocrinology Cancer
Histamine- ¹⁵N₃ is the ¹⁵N₃-labeled Histamine (HY-B1204). Histamine is the agonist for histamine receptor and a vasodilator. Histamine is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. Histamine affects p38 MAPK/Akt signaling pathway, exhibits antitumor, antioxidant and anti-inflammatory activities. Histamine can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma .

HY-B2176S3

ATP-15N5,d14 dilithium Adenosine 5'-triphosphate-15N5,d14 dilithium	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
ATP- ¹⁵N₅,d₁₄ (Adenosine 5'-triphosphate- ¹⁵N₅,d₁₄) dilithium is deuterium and ¹⁵N labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.

HY-147338S

5-Methylcytidine 5′-triphosphate-d3 trisodium 5-Methyl-CTP-d3 trisodium	DNA/RNA Synthesis Isotope-Labeled Compounds	Others
5-Methylcytidine 5′-triphosphate-d₃ trisodium is the deuterium labeled 5-Methylcytidine 5’-triphosphate trisodium (HY-147338A). 5-Methylcytidine 5′-triphosphate (5-Methyl-CTP) trisodium is a modified nucleoside triphosphate. 5-Methylcytidine 5′-triphosphate trisodium can apply in replacing unmodified mRNA, resulting in the increase of translational properties and stability, as well as the reduction of innate immune responses in human and other mammalian cells .

HY-147338S2

5-Methylcytidine 5′-triphosphate-d8 trisodium 5-Methyl-CTP-d8 trisodium	Isotope-Labeled Compounds	Inflammation/Immunology
5-Methylcytidine 5'-triphosphate-d₈ trisodium is the deuterium-labeled form of 5-Methylcytidine 5'-triphosphate trisodium (HY-147338A). 5-Methylcytidine 5'-triphosphate (5-Methyl-CTP) trisodium is a modified nucleoside triphosphate. 5-Methylcytidine 5'-triphosphate trisodium can be used to replace unmodified mRNA, resulting in the increase of translational properties and stability, as well as the reduction of innate immune responses in human and other mammalian cells .

HY-32350S1

Ercalcitriol-d3 1α,25-Dihydroxy Vitamin D2-d₃	Isotope-Labeled Compounds Endogenous Metabolite VD/VDR	Metabolic Disease
Ercalcitriol-d₃ (1α,25-Dihydroxy Vitamin D2-d₃) is the deuterium labeled Ercalcitriol (HY-32350). Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases .

HY-126855S

Cholic acid 7-sulfate-d4 7-Sulfocholic acid-d₄	Isotope-Labeled Compounds G protein-coupled Bile Acid Receptor 1 MHC	Metabolic Disease
Cholic acid 7-sulfate-d₄ (7-Sulfocholic acid-d₄) is the deuterium labeled Cholic acid 7-sulfate (HY-126855). Cholic acid 7-sulfate is a selective agonist targeting TGR5 (EC₅₀=0.17 μM) and a ligand for MHC class I-related protein (MR1). As a gut-restricted TGR5 agonist, cholic acid 7-sulfate binds to TGR5 on enteroendocrine L cells, induces GLP-1 secretion, and improves glucose tolerance in a TGR5-dependent manner. Cholic acid 7-sulfate also acts as an endogenous ligand for MR1, promoting the survival of mucosal-associated invariant T cells MAIT and the expression of homeostatic gene signatures, affecting MAIT cell development and function. Cholic acid 7-sulfate is mainly used in the research of diabetes and MAIT cell-related immune regulation .

HY-B1398S

Ampyrone-d3 4-Aminoantipyrine-d₃	Isotope-Labeled Compounds COX Drug Metabolite	Neurological Disease Inflammation/Immunology Cancer
Ampyrone-d₃ is the deuterium labeled Ampyrone (HY-B1398). Ampyrone (4-Aminophenazone; 4-Aminoantipyrine) is a reversible and low-damage optical clearing agent and non-selective COX inhibitor based on UV absorption properties. Ampyrone can improve the optical transmittance of mouse skin and other tissues. Ampyrone can induce tissue refractive index matching by enhancing UV absorption, reduce light scattering, and achieve tissue transparency in vivo. Ampyrone reduces the synthesis of prostaglandin PGE2, thereby exerting anti-inflammatory, analgesic and antipyretic effects. Ampyrone inhibits DNA damage, cell apoptosis and immune cell phagocytosis induced by Doxorubicin (HY-15142A) and Cisplatin (HY-17394), etc., and participates in the regulation of toxicity in tumor chemotherapy .

HY-B1953S

Thiacloprid-d4	nAChR Insecticide	Infection
Thiacloprid-d₄ is the deuterium labeled Thiacloprid. Thiacloprid is an orally active neurotoxic insecticide and also a nAChR agonist. Thiacloprid reduces the viability of healthy cells, depletes reduced glutathione, and increases MDA levels, thereby inducing cytotoxicity and oxidative stress damage. In practical applications, Thiacloprid has lower acute toxicity to honeybees than other compounds of the same class such as Imidacloprid (HY-B0838), but it still significantly impairs the learning and memory function, immune capacity and survival status of honeybees. Thiacloprid induces intestinal microbial dysbiosis and reduces survival rate in middle-aged honeybees, increases the risk of premature collapse in bumblebee colonies, and significantly decreases the final colony weight and reproductive output. Thiacloprid is used in broad-spectrum agricultural pest control, often alone or in combination with Deltamethrin (HY-B1971), and meets the pest management needs of various crops including potatoes, cabbages, various fruits and vegetables, and nuts .

HY-D2925

dTCOBG dTCO-SNAP	Biochemical Assay Reagents	Others
dTCOBG (dTCO-SNAP) is a SNAP-tag reactive benzylguanine (BG) analogue specifically designed for the specific labeling of immune cells. dTCOBG forms a stable thioether bond through the cysteine at the active site of SNAP-tag and O6-benzylguanine, resulting in a covalent linkage. dTCOBG demonstrates unique advantages in the labeling of macrophages derived from ER-HoxB8: it only labels SNAP-tag + macrophages, with no background signal in the control group. dTCOBG can be used for click chemistry labeling .

HY-158467

Core 1 O-glycan (C1), 2AB labelled	Biochemical Assay Reagents	Others
Core 1 O-glycan (C1), 2AB labeled is a 2AB (2-aminobenzamide) labeled O-linked glycan with core structure 1 (MUC1-M). Core 1 O-glycan (C1), 2AB labeled is related to sialylation and participates in life activities including cell recognition, protection, immune regulation and disease markers .

HY-158469

Disialylated Core 1 O-glycan (C1S(3,6)2), 2-AB labelled	Biochemical Assay Reagents	Others
Disialylated Core 1 O-glycan (C1S(3,6)2), 2-AB labeled is a disialylated, 2-AB (2-aminobenzamide) labeled O-linked glycan with core structure 1 (MUC1-M). Disialylated Core 1 O-glycan (C1S(3,6)2), 2-AB labeled is related to sialylation and participates in life activities including cell recognition, protection, immune regulation and disease markers .

HY-B2176S8

ATP-13C10,15N5,d14 dilithium Adenosine 5'-triphosphate-13C10,15N5,d14 dilithium	Isotope-Labeled Compounds Endogenous Metabolite NOD-like Receptor (NLR) Interleukin Related Bacterial	Others
ATP- ¹³C₁₀, ¹⁵N₅,d₁₄ (Adenosine 5'-triphosphate- ¹³C₁₀, ¹⁵N₅,d₁₄) dilithium is the ¹³C-, ¹⁵N- and deuterium labeled ATP dilithium. ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice.

Cat. No.	Product Name	Type

HY-D2396

Sulfo SMCC R-phycoerythrin Sulfo SMCC R-PE	Fluorescent Dyes
Sulfo SMCC R-phycoerythrin is a conjugate composed of the protein crosslinker SMCC (HY-42360) and R-PE (R-Phycoerythrin) (HY-D0988) that can be used to label proteins to make them carry red fluorescence. Among them, SMCC is able to engage antigen-coupled spleen cells to induce antigen-specific immune responses .

HY-D2925

dTCOBG dTCO-SNAP	Fluorescent Dyes
dTCOBG (dTCO-SNAP) is a SNAP-tag reactive benzylguanine (BG) analogue specifically designed for the specific labeling of immune cells. dTCOBG forms a stable thioether bond through the cysteine at the active site of SNAP-tag and O6-benzylguanine, resulting in a covalent linkage. dTCOBG demonstrates unique advantages in the labeling of macrophages derived from ER-HoxB8: it only labels SNAP-tag + macrophages, with no background signal in the control group. dTCOBG can be used for click chemistry labeling .

dTCOBG

dTCO-SNAP

Fluorescent Dyes

dTCOBG (dTCO-SNAP) is a SNAP-tag reactive benzylguanine (BG) analogue specifically designed for the specific labeling of immune cells. dTCOBG forms a stable thioether bond through the cysteine at the active site of SNAP-tag and O6-benzylguanine, resulting in a covalent linkage. dTCOBG demonstrates unique advantages in the labeling of macrophages derived from ER-HoxB8: it only labels SNAP-tag + macrophages, with no background signal in the control group. dTCOBG can be used for click chemistry labeling .

Cat. No.	Product Name	Type

HY-112624I

Dextran T3 (MW 3,000)

Dextran 3; Dextran D3; Dextran T3(MW 2400-3600)

Biochemical Assay Reagents

Dextran T3 (Dextran 3; Dextran T3(MW 2400-3600)) is a neural tracer and intestinal permeability probe that can move anterogradely and retrogradely in neuronal axons by passive diffusion. Dextran T3 (MW 3,000) is able to permeate across the intestinal epithelial cell membrane in the presence of cholera toxin-induced cytoskeletal disturbance. Dextran T3 (MW 3,000) is used as a fluorescent marker to rapidly label developing neurons (such as Xenopus retinal ganglion cells) and to assess intestinal barrier function. It can be used to study axonal transport in neuroanatomy and permeability changes in intestinal pathophysiology. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance .

HY-158471

Core 1 O-glycan (C1)	Biochemical Assay Reagents
Core 1 O-glycan (C1) is an important O-linked glycan with core structure 1 (MUC1-M). Core 1 O-glycan (C1), 2AB labeled is related to sialylation and participates in life activities including cell recognition, protection, immune regulation and disease markers .

HY-158470

Disialylated Core 2 O-glycan (C2S(3,3)2), 2-AB labelled	Biochemical Assay Reagents
Disialylated Core 2 O-glycan (C2S(3,3)2), 2-AB labeled is a 2-AB (2-aminobenzamide) labeled O-linked glycan with core structure 2. Disialylated Core 2 O-glycan (C2S(3,3)2), 2-AB labeled is related to sialylation and participates in life activities including cell recognition, protection, immune regulation and disease markers .

HY-158467

Core 1 O-glycan (C1), 2AB labelled	Biochemical Assay Reagents
Core 1 O-glycan (C1), 2AB labeled is a 2AB (2-aminobenzamide) labeled O-linked glycan with core structure 1 (MUC1-M). Core 1 O-glycan (C1), 2AB labeled is related to sialylation and participates in life activities including cell recognition, protection, immune regulation and disease markers .

HY-158469

Disialylated Core 1 O-glycan (C1S(3,6)2), 2-AB labelled	Biochemical Assay Reagents
Disialylated Core 1 O-glycan (C1S(3,6)2), 2-AB labeled is a disialylated, 2-AB (2-aminobenzamide) labeled O-linked glycan with core structure 1 (MUC1-M). Disialylated Core 1 O-glycan (C1S(3,6)2), 2-AB labeled is related to sialylation and participates in life activities including cell recognition, protection, immune regulation and disease markers .

Cat. No.	Product Name	Chemical Structure

HY-B2176S

ATP-13C10,15N5
ATP- ¹³C₁₀, ¹⁵N₅ is the ¹³C and ¹⁵N labeled ATP . ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation .

HY-B2176S6

ATP-13C10 dilithium
ATP- ¹³C₁₀ (Adenosine 5'-triphosphate- ¹³C₁₀) dilithium is ¹³C-labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.

HY-B2176S5

ATP-15N5 dilithium
ATP- ¹⁵N₅ (Adenosine 5'-triphosphate- ¹⁵N₅) dilithium is ¹⁵N labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.

HY-B1946S

Dimethoate-d6
Dimethoate-d₆ is the deuterium labeled Dimethoate. Dimethoate is an organophosphate insecticide and acaricide. Dimethoate is an orally active acetylcholinesterase inhibitor. Dimethoate induces reactive oxygen species (ROS). Dimethoate induces DNA damage and cell apoptosis in vivo. Dimethoate affect immune system in mice .

HY-B0345AS

ATP-18O4 sodium
ATP- ¹⁸O₄ (disodium salt) is the ¹⁸O labeled ATP disodium salt . ATP disodium salt (Adenosine 5'-triphosphate disodium salt) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt is an important endogenous signaling molecule in immunity and inflammation .

HY-W014375S4

DL-Arginine-13C6,15N4 hydrochloride

DL-Arginine- ¹³C₆, ¹⁵N₄ hydrochloride is ¹³C and ¹⁵N-labeled DL-Arginine hydrochloride (HY-W014375). DL-Arginine ((±)-Arginine) hydrochloride is the racemic compound of L-Arginine (HY-N0455) and D-Arginine (HY-W016781). Arginine is an essential amino acid that requires additional supplementation in traumatic or diseased conditions. Arginine is involved in T cell activation, proliferation, and differentiation, and affects the function of immune cells .

HY-B2176S4

ATP-d14 dilithium
ATP-d₁₄ (Adenosine 5'-triphosphate-d₁₄) dilithium is deuterium labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.

HY-B2176S7

ATP-13C2 dilithium
ATP- ¹³C₂ (Adenosine 5'-triphosphate- ¹³C₂) dilithium is ¹³C-labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.

HY-W010243S

Methylisothiazolinone-d3 hydrochloride

Methylisothiazolinone-d₃ hydrochloride is the deuterium labeled Methylisothiazolinone hydrochloride (HY-W010243). Methylisothiazolinone hydrochloride is a bacterial and fungal inhibitor and preservative, as well as a sensitizer. Methylisothiazolinone hydrochloride can activate matrix metalloproteinases (MMPs) in human bronchial epithelial cells to induce apoptosis and inflammatory response. Methylisothiazolinone hydrochloride can promote the development of atopic dermatitis in mice by disrupting Th2/Th17 related immune responses. Methylisothiazolinone hydrochloride can cause mitochondrial damage in the endothelium of rat cerebral blood vessels .

HY-150709S1

Adenosine 5'-triphosphate-13C10,15N5 dilithium

Adenosine 5'-triphosphate-13C10,15N5 dilithium is 13C and 15N labeled dilithium salt form of Adenosine 5'-triphosphate (HY-B2176). Adenosine 5'-triphosphate is a central component of energy storage and metabolism in vivo. Adenosine 5'-triphosphate provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. Adenosine 5'-triphosphate is an important endogenous signaling molecule in immunity and inflammation .

HY-N0349S1

Methyl paraben-13C6

Methyl Paraben- ¹³C₆ (Methyl 4-hydroxybenzoate- ¹³C₆) is a ¹³C labeled Methyl Paraben (HY-N0349) . Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, agents and cosmetics. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity .

HY-B1204S1

Histamine-d4

Histamine-d₄ (Ergamine-d₄) is deuterium labeled Histamine (HY-B1204). Histamine is the agonist for histamine receptor and a vasodilator. Histamine is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. Histamine affects p38 MAPK/Akt signaling pathway, exhibits antitumor, antioxidant and anti-inflammatory activities. Histamine can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma .

HY-114364S

UDP-α-D-Galactose-13C disodium

UDP-α-D-Galactose- ¹³C disodium is the ¹³C labeled UDP-α-D-Galactose disodium. UDP-Galactose disodium is a monosaccharide and a key glycosyl donor molecule in cells that participates in nucleotide sugar metabolism. UDP-Galactose disodium is the natural agonist of the P2Y₁₄ receptor coupled to G_i proteins in the immune system (IC₅₀= 0.67 μM, hP2Y₁₄). UDP-Galactose disodium can be used to study cell signal transduction and substance metabolism .

HY-15306S

Eltrombopag-13C4

1 Publications Verification

Eltrombopag- ¹³C₄ (SB-497115- ¹³C₄) is ^{13 sup>C-labeled Z-Eltrombopag. Z-Eltrombopag is an orally active thrombopoietin-receptor non-peptide agonist with platelet-stimulating activity for the study of chronic immune thrombocytopenia. Eltrombopag also has strong inhibitory effects on multidrug-resistant Staphylococcus aureus (Staphylococcus aureus) and can induce apoptosis (apoptosis) in liver cancer cells .}

HY-143712S1

Allolithocholic Acid-d4

Allolithocholic Acid-d₄ (3α-hydoxy-5α-Cholaoic Acid-d₄, allo-LCA-d₄) is deuterium labeled Allolithocholic acid (HY-143712). Allolithocholic acid is an orally active metabolite of Lithocholic acid (HY-B0172). Allolithocholic acid is a dual GPBAR1 agonist (EC₅₀ = 2.7 μM) and RORγt inverse agonist (IC₅₀ = 3.4 μM). Allolithocholic acid modulates immune and metabolic pathways, regulates immune cell polarization, prevents M1 macrophage and Th17 CD4 cell polarization. Allolithocholic acid improves insulin sensitivity, reduces liver lipid accumulation, reverses liver immunological, inflammatory and metabolic signaling dysregulation, restores bile acid homeostasis, adipose tissue histopathology/function, and intestinal microbiota composition, modulates intestinal immunity. Allolithocholic acid can be used for the researches of cancer, inflammayion, immunology and metabolic disease .

HY-N0349S

Methyl paraben-d4

Methyl paraben-d₄ is the deuterium labeled Methyl Paraben . Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, agents and cosmetics. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity .

HY-W653896

Alternariol-d2

Alternariol-d₂ is deuterium labeled Alternariol. Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects .

HY-B1204S2

Histamine-13C5, 15N3

Histamine- ¹³C₅, ¹⁵N₃ (Ergamine- ¹³C₅, ¹⁵N₃) is the ¹³C and ¹⁵N labeled isotope of Histamine (HY-B1204). Histamine is the agonist for histamine receptor and a vasodilator. Histamine is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. Histamine affects p38 MAPK/Akt signaling pathway, exhibits antitumor, antioxidant and anti-inflammatory activities. Histamine can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma .

HY-W739948

Naltrexone-d3
Naltrexone-d₃ is a deuterated labeled Naltrexone (HY-76711) . Naltrexone is an antagonist of Opioid receptor. Naltrexone inhibits cell proliferation in vivo. Naltrexone reduces tumor growth by interfering with cell signalling and modifying the immune system .

HY-B2046S

Simazine-d10
Simazine-d₁₀ is the deuterium labeled Simazine (HY-B2046). Simazine is a triazine herbicide. Simazine is widely used in agriculture, potted plant and tree production. In addition, Simazine can induce the apoptosis of immune cells in the spleen of mice and inhibit the proliferation of B cells and T cells in mice .

HY-N6746S1

Citrinin-13C13

Citrinin- ¹³C₁₃ (NSC 186- ¹³C₁₃) is the ¹³C labeled Citrinin (HY-N6746). Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .

HY-W014375S3

DL-Arginine-d7 hydrochloride

DL-Arginine-d₇ hydrochloride is deuterium labeled DL-Arginine hydrochloride (HY-W014375). DL-Arginine ((±)-Arginine) hydrochloride is the racemic compound of L-Arginine (HY-N0455) and D-Arginine (HY-W016781). Arginine is an essential amino acid that requires additional supplementation in traumatic or diseased conditions. Arginine is involved in T cell activation, proliferation, and differentiation, and affects the function of immune cells .

HY-W014375S

DL-Arginine-15N4,d7 hydrochloride

DL-Arginine- ¹⁵N₄,d₇ hydrochloride is deuterium and ¹⁵N labeled DL-Arginine hydrochloride (HY-W014375). DL-Arginine ((±)-Arginine) hydrochloride is the racemic compound of L-Arginine (HY-N0455) and D-Arginine (HY-W016781). Arginine is an essential amino acid that requires additional supplementation in traumatic or diseased conditions. Arginine is involved in T cell activation, proliferation, and differentiation, and affects the function of immune cells .

HY-124356AS

Alcaftadine carboxylic acid-d3 sodium

Alcaftadine carboxylic acid-d₃ (sodium) is deuterium labeled Alcaftadine carboxylic acid. Alcaftadine carboxylic acid is a broad-spectrum antihistamine compound with high affinity for histamine H1 and H2 receptors and low affinity for H4 receptors. Alcaftadine carboxylic acid has also demonstrated effects on modulating immune cell recruitment and stabilizing mast cells. Alcaftadine carboxylic acid is more effective than placebo in preventing ocular itching associated with allergic conjunctivitis and is at least as effective as olopatadine 0.01% .

HY-W014375S1

DL-Arginine-13C6,15N4,d7 hydrochloride

DL-Arginine- ¹³C₆, ¹⁵N₄,d₇ hydrochloride is ¹³C and ¹⁵N-labeled DL-Arginine hydrochloride (HY-W014375). DL-Arginine ((±)-Arginine) hydrochloride is the racemic compound of L-Arginine (HY-N0455) and D-Arginine (HY-W016781). Arginine is an essential amino acid that requires additional supplementation in traumatic or diseased conditions. Arginine is involved in T cell activation, proliferation, and differentiation, and affects the function of immune cells .

HY-106161S1

Rupintrivir-d7

Rupintrivir-d7 is a deuterated labeled Rupintrivir . Rupintrivirvr (AG7088), an antiviral agent, is a potent, selective and irreversible inhibitor of human rhinovirus (HRV) 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays, with a mean EC₅₀ of 0.023 μM. Rupintrivirvr shows immune-modulatory effect .

HY-B1204S4

Histamine-15N3

Histamine- ¹⁵N₃ is the ¹⁵N₃-labeled Histamine (HY-B1204). Histamine is the agonist for histamine receptor and a vasodilator. Histamine is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. Histamine affects p38 MAPK/Akt signaling pathway, exhibits antitumor, antioxidant and anti-inflammatory activities. Histamine can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma .

HY-B2176S3

ATP-15N5,d14 dilithium

ATP- ¹⁵N₅,d₁₄ (Adenosine 5'-triphosphate- ¹⁵N₅,d₁₄) dilithium is deuterium and ¹⁵N labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.

HY-147338S

5-Methylcytidine 5′-triphosphate-d3 trisodium

5-Methylcytidine 5′-triphosphate-d₃ trisodium is the deuterium labeled 5-Methylcytidine 5’-triphosphate trisodium (HY-147338A). 5-Methylcytidine 5′-triphosphate (5-Methyl-CTP) trisodium is a modified nucleoside triphosphate. 5-Methylcytidine 5′-triphosphate trisodium can apply in replacing unmodified mRNA, resulting in the increase of translational properties and stability, as well as the reduction of innate immune responses in human and other mammalian cells .

HY-147338S2

5-Methylcytidine 5′-triphosphate-d8 trisodium

5-Methylcytidine 5'-triphosphate-d₈ trisodium is the deuterium-labeled form of 5-Methylcytidine 5'-triphosphate trisodium (HY-147338A). 5-Methylcytidine 5'-triphosphate (5-Methyl-CTP) trisodium is a modified nucleoside triphosphate. 5-Methylcytidine 5'-triphosphate trisodium can be used to replace unmodified mRNA, resulting in the increase of translational properties and stability, as well as the reduction of innate immune responses in human and other mammalian cells .

HY-32350S1

Ercalcitriol-d3

Ercalcitriol-d₃ (1α,25-Dihydroxy Vitamin D2-d₃) is the deuterium labeled Ercalcitriol (HY-32350). Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases .

HY-126855S

Cholic acid 7-sulfate-d4

Cholic acid 7-sulfate-d₄ (7-Sulfocholic acid-d₄) is the deuterium labeled Cholic acid 7-sulfate (HY-126855). Cholic acid 7-sulfate is a selective agonist targeting TGR5 (EC₅₀=0.17 μM) and a ligand for MHC class I-related protein (MR1). As a gut-restricted TGR5 agonist, cholic acid 7-sulfate binds to TGR5 on enteroendocrine L cells, induces GLP-1 secretion, and improves glucose tolerance in a TGR5-dependent manner. Cholic acid 7-sulfate also acts as an endogenous ligand for MR1, promoting the survival of mucosal-associated invariant T cells MAIT and the expression of homeostatic gene signatures, affecting MAIT cell development and function. Cholic acid 7-sulfate is mainly used in the research of diabetes and MAIT cell-related immune regulation .

HY-B1398S

Ampyrone-d3

Ampyrone-d₃ is the deuterium labeled Ampyrone (HY-B1398). Ampyrone (4-Aminophenazone; 4-Aminoantipyrine) is a reversible and low-damage optical clearing agent and non-selective COX inhibitor based on UV absorption properties. Ampyrone can improve the optical transmittance of mouse skin and other tissues. Ampyrone can induce tissue refractive index matching by enhancing UV absorption, reduce light scattering, and achieve tissue transparency in vivo. Ampyrone reduces the synthesis of prostaglandin PGE2, thereby exerting anti-inflammatory, analgesic and antipyretic effects. Ampyrone inhibits DNA damage, cell apoptosis and immune cell phagocytosis induced by Doxorubicin (HY-15142A) and Cisplatin (HY-17394), etc., and participates in the regulation of toxicity in tumor chemotherapy .

HY-B1953S

Thiacloprid-d4

Thiacloprid-d₄ is the deuterium labeled Thiacloprid. Thiacloprid is an orally active neurotoxic insecticide and also a nAChR agonist. Thiacloprid reduces the viability of healthy cells, depletes reduced glutathione, and increases MDA levels, thereby inducing cytotoxicity and oxidative stress damage. In practical applications, Thiacloprid has lower acute toxicity to honeybees than other compounds of the same class such as Imidacloprid (HY-B0838), but it still significantly impairs the learning and memory function, immune capacity and survival status of honeybees. Thiacloprid induces intestinal microbial dysbiosis and reduces survival rate in middle-aged honeybees, increases the risk of premature collapse in bumblebee colonies, and significantly decreases the final colony weight and reproductive output. Thiacloprid is used in broad-spectrum agricultural pest control, often alone or in combination with Deltamethrin (HY-B1971), and meets the pest management needs of various crops including potatoes, cabbages, various fruits and vegetables, and nuts .

HY-B2176S8

ATP-13C10,15N5,d14 dilithium

ATP- ¹³C₁₀, ¹⁵N₅,d₁₄ (Adenosine 5'-triphosphate- ¹³C₁₀, ¹⁵N₅,d₁₄) dilithium is the ¹³C-, ¹⁵N- and deuterium labeled ATP dilithium. ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice.

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