Methyl Paraben-13C6
Methyl Paraben-13C6 (Methyl 4-hydroxybenzoate-13C6) is a 13C labeled Methyl Paraben (HY-N0349). Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, agents and cosmetics. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity.
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- CAS. Nr.: 1581694-95-2
- Formel: C213C6H8O3
- Molecular Weight:158.10
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Anwendung
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 1581694-95-2
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Unlabeled CAS 99-76-3
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Appearance Solid
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Molecular Weight 158.10
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Formel C213C6H8O3
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Color White to off-white
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SMILES
O=C(OC)[13C]1=[13CH][13CH]=[13C](O)[13CH]=[13CH]1
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Synonyms
Methyl 4-hydroxybenzoate-13C6
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 100 mg/mL (632.51 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Reinheit & Dokumentation
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Data Sheet (271 KB)
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SDS (458 KB)
- English - EN (458 KB)
- Français - FR (458 KB)
- Deutsch - DE (458 KB)
- Norwegian - NO (458 KB)
- Español - ES (458 KB)
- Swedish - SV (458 KB)
- Italian - IT (458 KB)
- Korean - KR (458 KB)
- Portuguese - PT (458 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246. [Content Brief]
[2]. Soni MG, et al. Evaluation of the health aspects of methyl paraben: a review of the published literature. Food Chem Toxicol. 2002 Oct;40(10):1335-73. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 6.3251 mL | 31.6256 mL | 63.2511 mL | 158.1278 mL |
| 5 mM | 1.2650 mL | 6.3251 mL | 12.6502 mL | 31.6256 mL | |
| 10 mM | 0.6325 mL | 3.1626 mL | 6.3251 mL | 15.8128 mL | |
| 15 mM | 0.4217 mL | 2.1084 mL | 4.2167 mL | 10.5419 mL | |
| 20 mM | 0.3163 mL | 1.5813 mL | 3.1626 mL | 7.9064 mL | |
| 25 mM | 0.2530 mL | 1.2650 mL | 2.5300 mL | 6.3251 mL | |
| 30 mM | 0.2108 mL | 1.0542 mL | 2.1084 mL | 5.2709 mL | |
| 40 mM | 0.1581 mL | 0.7906 mL | 1.5813 mL | 3.9532 mL | |
| 50 mM | 0.1265 mL | 0.6325 mL | 1.2650 mL | 3.1626 mL | |
| 60 mM | 0.1054 mL | 0.5271 mL | 1.0542 mL | 2.6355 mL | |
| 80 mM | 0.0791 mL | 0.3953 mL | 0.7906 mL | 1.9766 mL | |
| 100 mM | 0.0633 mL | 0.3163 mL | 0.6325 mL | 1.5813 mL |
Methyl Paraben-13C6 Related Classifications
HY-N0349S1 Related Classifications
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