Leukotriene E4-d5
Based on 1 Customer Validation
Leukotriene E4-d5 (LTE4-d5) is the d-5-labeled Leukotriene E4 (HY-113465). Leukotriene E4 is a stable final metabolite of cysteinyl leukotrienes, produced by immune cells such as mast cells and eosinophils. Leukotriene E4 serves as a key biomarker for evaluating asthma severity, Aspirin (HY-14654) sensitivity, and mast cell activation disorders. Leukotriene E4 is a full functional agonist of CysLT1R, which induces sustained intracellular calcium mobilization and Erk phosphorylation. Leukotriene E4 mediates inflammation in a P2Y12 receptor-dependent manner. Leukotriene E4 can be used in the research of asthma and non-steroidal anti-inflammatory drug-exacerbated respiratory diseases.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.5%
- CAS. Nr.: 1240398-14-4
- Formel: C23H32D5NO5S
- Molecular Weight:444.64
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Speicherung:
Solution, -20°C, 2 years
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
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Biologische Aktivität
Beschreibung
Anwendung
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 1240398-14-4
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Unlabeled CAS 75715-89-8
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Appearance Liquid
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Molecular Weight 444.64
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Formel C23H32D5NO5S
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Color Colorless to light yellow
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SMILES
OC(CCC[C@H](O)[C@@H](/C=C/C=C/C=C\C/C=C\CCCC([2H])([2H])C([2H])([2H])[2H])SC[C@H](N)C(O)=O)=O
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Synonyms
LTE4-d5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Solution, -20°C, 2 years
Reinheit & Dokumentation
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Data Sheet (263 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Leukotriene E4-d5 Related Classifications
HY-113465S Related Classifications
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Keywords
- Leukotriene E4-d5
- 1240398-14-4
- LTE4-d5
- Isotope-Labeled Compounds
- Endogenous Metabolite
- Leukotriene Receptor
- Calcium Channel
- ERK
- P2Y Receptor
- CysLT1
- HEK293T cells
- BALB/c mice
- C57BL/6 mice
- P2Y12
- NSAID-exacerbated respiratory disease
- Chinese hamster ovary cells
- LAD2 human mast cells
- LUVA human mast cells
- asthma
- Inhibitor
- inhibitor
- inhibit