Leukotriene E4-d5
Leukotriene E4-d5 (LTE4-d5) is the d5-labeled Leukotriene E4 (HY-113465). Leukotriene E4 is a stable final metabolite of cysteinyl leukotrienes, produced by immune cells such as mast cells and eosinophils. Leukotriene E4 serves as a key biomarker for evaluating asthma severity, Aspirin (HY-14654) sensitivity, and mast cell activation disorders. Leukotriene E4 is a full functional agonist of CysLT1R, which induces sustained intracellular calcium mobilization and Erk phosphorylation. Leukotriene E4 mediates inflammation in a P2Y12 receptor-dependent manner. Leukotriene E4 can be used in the research of asthma and non-steroidal anti-inflammatory drug-exacerbated respiratory diseases.
The product specifications provided below refer solely to the active content of Leukotriene E4-d5.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 98.5%
- CAS No.: 1240398-14-4
- Formule: C23H32D5NO5S
- Masse moléculaire:444.64
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Stockage:
Solution, -20°C, 2 years
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Voir tous les produits spécifiques à Isoform Endogenous Metabolite
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Activité biologique
Description
The product specifications provided below refer solely to the active content of Leukotriene E4-d5.
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1240398-14-4
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Unlabeled CAS 75715-89-8
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Appearance Liquid
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Masse moléculaire 444.64
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Formule C23H32D5NO5S
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Color Colorless to light yellow
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SMILES
OC(CCC[C@H](O)[C@@H](/C=C/C=C/C=C\C/C=C\CCCC([2H])([2H])C([2H])([2H])[2H])SC[C@H](N)C(O)=O)=O
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Synonyms
LTE4-d5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Solution, -20°C, 2 years
Pureté et documentation
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Fiche technique (271 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Leukotriene E4-d5 Related Classifications
HY-113465S Related Classifications
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Keywords
- Leukotriene E4-d5
- 1240398-14-4
- LTE4-d5
- Isotope-Labeled Compounds
- Endogenous Metabolite
- Leukotriene Receptor
- Calcium Channel
- ERK
- P2Y Receptor
- Ca2+ channels
- Ca channels
- Extracellular signal regulated kinases
- CysLT1
- HEK293T cells
- BALB/c mice
- C57BL/6 mice
- P2Y12
- NSAID-exacerbated respiratory disease
- Chinese hamster ovary cells
- LAD2 human mast cells
- LUVA human mast cells
- asthma
- Inhibitor
- inhibitor
- inhibit