1240398-14-4
Chemical Structure
Leukotriene E4-d5
Synonym(s): LTE4-d5
- CAS No.: 1240398-14-4
- Formula:C23H32D5NO5S
- Molecular Weight:444.64
IUPAC Name: (5S,6R,7E,9E,11Z,14Z)-6-(((R)-2-amino-2-carboxyethyl)thio)-5-hydroxyicosa-7,9,11,14-tetraenoic-19,19,20,20,20-d5 acid
InChIKey: OTZRAYGBFWZKMX-XPGOKVCBSA-N
SMILES: OC(CCC[C@H](O)[C@@H](/C=C/C=C/C=C\C/C=C\CCCC([2H])([2H])C([2H])([2H])[2H])SC[C@H](N)C(O)=O)=O
Biological Activity: Leukotriene E4-d5 (LTE4-d5) is the d-5-labeled Leukotriene E4 (HY-113465). Leukotriene E4 is a stable final metabolite of cysteinyl leukotrienes, produced by immune cells such as mast cells and eosinophils. Leukotriene E4 serves as a key biomarker for evaluating asthma severity, Aspirin (HY-14654) sensitivity, and mast cell activation disorders. Leukotriene E4 is a full functional agonist of CysLT1R, which induces sustained intracellular calcium mobilization and Erk phosphorylation. Leukotriene E4 mediates inflammation in a P2Y12 receptor-dependent manner. Leukotriene E4 can be used in the research of asthma and non-steroidal anti-inflammatory drug-exacerbated respiratory diseases[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Leukotriene E4-d5 | 98.5% | Leukotriene E4-d5 (LTE4-d5) is the d-5-labeled Leukotriene E4 (HY-113465). Leukotriene E4 is a stable final metabolite of cysteinyl leukotrienes, produced by immune cells such as mast cells and eosinophils. Leukotriene E4 serves as a key biomarker for evaluating asthma severity, Aspirin (HY-14654) sensitivity, and mast cell activation disorders. Leukotriene E4 is a full functional agonist of CysLT1R, which induces sustained intracellular calcium mobilization and Erk phosphorylation. Leukotriene E4 mediates inflammation in a P2Y12 receptor-dependent manner. Leukotriene E4 can be used in the research of asthma and non-steroidal anti-inflammatory drug-exacerbated respiratory diseases. | ||||||||||||||||||||
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Leukotriene E4 | 99.80% | Leukotriene E4 (LTE4) is produced by the action of dipeptidase on LTD4. Leukotriene E4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A). Leukotriene E4 accumulates in both plasma and urine and urinary excretion of Leukotriene E4 is most often used as an indicator of asthma. | ||||||||||||||||||||
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Keywords
