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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
insulinotropic activity
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "insulinotropic activity" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-W017387
CAS No.: 4502-00-5
Synonyms: Sodium 4-methyl-2-oxopentanoate; 2-Ketoisocaproic acid sodium salt
Research Areas:
Sodium α-ketoisocaproate (Sodium 4-methyl-2-oxopentanoate) is an insulin secretagogue. Sodium α-ketoisocaproate undergoes transamination catalyzed by BCAT and BCATm to produce α-ketoglutarate and leucine; it also binds to the SUR1 site to inhibit KATP channel activity, but does not directly affect the Kir6.2 subunit. Sodium α-ketoisocaproate regulates Ca 2+ influx. Sodium α-ketoisocaproate exerts insulinotropic activity in pancreatic islets and intact mouse pancreata with sufficient BCATm expression. Sodium α-ketoisocaproate can be used in research related to type 2 diabetes .
Cat. No.: HY-164535
CAS No.: 2887445-76-1
Synonyms: AMG 133
Cat. No.: HY-P1348
CAS No.: 1197810-60-8
Synonyms: [Gly8,36,Glu22]-GLP-1 (7-37)
Target:
Research Areas:
Cat. No.: HY-W017387S
CAS No.: 93523-67-2
Synonyms: Sodium 4-methyl-2-oxopentanoate-d3; 2-Ketoisocaproic acid-d3 sodium salt
Cat. No.: HY-146455
CAS No.: 2402735-14-0
Research Areas:
DPP-4-IN-3 (Compound 5a) is a potent dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 0.75 nM. DPP-4-IN-3 shows excellent antioxidant and insulinotropic activity .
Cat. No.: HY-10287A
CAS No.: 869490-47-1
Target:
Research Areas:
Gosogliptin hydrochloride is the hydrochloride of Gosogliptin (HY-10287). Gosogliptin (PF-00734200) is a potent, orally active, selective, and competitive inhibitor of DPP-IV, the enzyme mainly responsible for the degradation of the incretin peptides GLP-1 and glucose-dependent insulinotropic polypeptide. Gosogliptin demonstrates rapid and reversible inhibition of plasma DPP-4 activity. Gosogliptin stimulates insulin secretion and improves glucose tolerance .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
