Sodium α-ketoisocaproate-d3
Based on 1 Customer Validation
Sodium α-ketoisocaproate-d3 (Sodium 4-methyl-2-oxopentanoate-d3; 2-Ketoisocaproic acid-d3 (sodium salt)) is the deuterated-labeled Sodium α-ketoisocaproate (HY-W017387). Sodium α-ketoisocaproate (Sodium 4-methyl-2-oxopentanoate) is an insulin secretagogue. Sodium α-ketoisocaproate undergoes transamination catalyzed by BCAT and BCATm to produce α-ketoglutarate and leucine; it also binds to the SUR1 site to inhibit KATP channel activity, but does not directly affect the Kir6.2 subunit. Sodium α-ketoisocaproate regulates Ca2+ influx. Sodium α-ketoisocaproate exerts insulinotropic activity in pancreatic islets and intact mouse pancreata with sufficient BCATm expression. Sodium α-ketoisocaproate can be used in research related to type 2 diabetes.
For research use only. We do not sell to patients.
- Purity: 98.48%
- CAS No.: 93523-67-2
- Formula: C6H6D3NaO3
- Molecular Weight:155.14
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS No. 93523-67-2
-
Unlabeled Cas 4502-00-5
-
Appearance Solid
-
Molecular Weight 155.14
-
Formula C6H6D3NaO3
-
Color White to off-white
-
SMILES
[2H]C([2H])(C(CC(C(O[Na])=O)=O)C)[2H]
-
Synonyms
Sodium 4-methyl-2-oxopentanoate-d3; 2-Ketoisocaproic acid-d3 sodium salt
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
Ethanol : ≥ 5 mg/mL (32.23 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (272 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Rabaglia ME, et al. Alpha-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice. Am J Physiol Endocrinol Metab. 2005;289(2):E218-E224. [Content Brief]
[2]. Heissig H, et al. Mechanism of the insulin-releasing action of alpha-ketoisocaproate and related alpha-keto acid anions. Mol Pharmacol. 2005 Oct;68(4):1097-105. [Content Brief]
[3]. Zhou Y, et al. Transamination is required for {alpha}-ketoisocaproate but not leucine to stimulate insulin secretion. J Biol Chem. 2010 Oct 29;285(44):33718-26. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 6.4458 mL | 32.2290 mL | 64.4579 mL | 161.1448 mL |
| 5 mM | 1.2892 mL | 6.4458 mL | 12.8916 mL | 32.2290 mL | |
| 10 mM | 0.6446 mL | 3.2229 mL | 6.4458 mL | 16.1145 mL | |
| 15 mM | 0.4297 mL | 2.1486 mL | 4.2972 mL | 10.7430 mL | |
| 20 mM | 0.3223 mL | 1.6114 mL | 3.2229 mL | 8.0572 mL | |
| 25 mM | 0.2578 mL | 1.2892 mL | 2.5783 mL | 6.4458 mL | |
| 30 mM | 0.2149 mL | 1.0743 mL | 2.1486 mL | 5.3715 mL |
Sodium α-ketoisocaproate-d3 Related Classifications
HY-W017387S Related Classifications
Powered by Bioz
- Sodium α-ketoisocaproate-d3
- 93523-67-2
- Sodium 4-methyl-2-oxopentanoate-d3
- 2-Ketoisocaproic acid-d3
- Isotope-Labeled Compounds
- Branched Chain Amino Acid Transaminase (BCAT)
- Potassium Channel
- Na+/Ca2+ Exchanger
- SUR1
- BCAT
- COS-7 cells
- pancreatic islets
- BTBR islets
- Kir6.2
- type 2 diabetes
- pancreatic β-cells
- BCATm
- SUR2B
- Inhibitor
- inhibitor
- inhibit