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labdane-type diterpenoid

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By Targets:	Drug Derivative (2) Drug Intermediate (1) Endogenous Metabolite (1) Insecticide (1)
By Research Areas:	Cancer (2) Inflammation/Immunology (1) Neurological Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-121839

Manoyl oxide	Endogenous Metabolite	Others
Manoyl oxide is a labdane-type diterpenoid. Manoyl oxide is the precursor of Forskolin (HY-15371) .

HY-N17484

Agatholic acid	Others	Others
Agatholic acid is a labdane-type diterpenoid acid that can be found in defoliated twigs of Pinus pumila .

HY-N16811

Yunnancoronarin C	Others	Cancer
Yunnancoronarin C is a labdane-type diterpenoid that can be isolated from the rhizomes of Hedychium forrestii, exhibits cytotoxicity against leukemia cells. Yunnancoronarin C can be used for the research of leukemia .

HY-136974

9-Deoxyforskolin	Drug Derivative	Others
9-Deoxyforskolin (compound 2) is a labdane-type diterpenoid, and also a forskolin derivative identified in hairy root cultures of Coleus forskohlii .

HY-N17787

Labdanolic acid	Drug Intermediate	Inflammation/Immunology
Labdanolic acid is a labdane-type diterpenoid compound that can be isolated from Cistus ladaniferus, a plant growing in Portugal. Labdanolic acid is a key intermediate in the synthesis of anti-inflammatory molecules and has both medicinal and industrial applications .

HY-N15634

Anticopalic acid	Insecticide	Neurological Disease
Anticopalic acid is a labdane-type diterpenoid insect antifeedant that exhibits dose-dependent antifeedant activity against the fall armyworm (Spodoptera frugiperda). Anticopalic acid can be isolated from Vitex hemsleyi. Anticopalic acid may be involved in neuroreceptor-mediated insect taste regulation and could be used to develop environmentally friendly antifeedants targeting lepidopteran pests .

HY-N19664

14-Deoxy-12-methoxyandrographolide	Others	Cancer
14-Deoxy-12-methoxyandrographolide, an ent-labdane-type diterpenoid found in the aerial parts of Andrographis paniculata, is a cell differentiation inducer. 14-Deoxy-12-methoxyandrographolide induces differentiation of myeloid leukemia cells via increased phagocytosis of polystyrene latex particles. 14-Deoxy-12-methoxyandrographolide can be used for the research of myeloid leukemia .

HY-N16806

Yunnancoronarin B	Drug Derivative	Others
Yunnancoronarin B is a natural diterpene.

Agatholic acid	Structural Classification Pinaceae Terpenoids Pinus pumila (Pall.) Regel Diterpenoids Plants Source Classification	Others
Agatholic acid is a labdane-type diterpenoid acid that can be found in defoliated twigs of Pinus pumila .

Yunnancoronarin C	Structural Classification Hedychium forrestii Diels Terpenoids Diterpenoids Plants Source Classification Zingiberaceae	Others
Yunnancoronarin C is a labdane-type diterpenoid that can be isolated from the rhizomes of Hedychium forrestii, exhibits cytotoxicity against leukemia cells. Yunnancoronarin C can be used for the research of leukemia .

9-Deoxyforskolin	Structural Classification Terpenoids Labiatae Diterpenoids Plants Pueraria montana (Lour.) Merr. Source Classification	Drug Derivative
9-Deoxyforskolin (compound 2) is a labdane-type diterpenoid, and also a forskolin derivative identified in hairy root cultures of Coleus forskohlii .

Labdanolic acid	Structural Classification Ketones, Aldehydes, Acids Talinum calycinum Engelm. in Wisl. Plants Talinaceae Source Classification	Drug Intermediate
Labdanolic acid is a labdane-type diterpenoid compound that can be isolated from Cistus ladaniferus, a plant growing in Portugal. Labdanolic acid is a key intermediate in the synthesis of anti-inflammatory molecules and has both medicinal and industrial applications .

Anticopalic acid	Structural Classification Ketones, Aldehydes, Acids Labiatae Petasites hybridus (L.) G.Gaertn., B.Mey. & Schreb. Plants Source Classification	Insecticide
Anticopalic acid is a labdane-type diterpenoid insect antifeedant that exhibits dose-dependent antifeedant activity against the fall armyworm (Spodoptera frugiperda). Anticopalic acid can be isolated from Vitex hemsleyi. Anticopalic acid may be involved in neuroreceptor-mediated insect taste regulation and could be used to develop environmentally friendly antifeedants targeting lepidopteran pests .

14-Deoxy-12-methoxyandrographolide	Structural Classification Acanthaceae Simsia foetida (Cav.) S.F.Blake Terpenoids Diterpenoids Plants Source Classification	Others
14-Deoxy-12-methoxyandrographolide, an ent-labdane-type diterpenoid found in the aerial parts of Andrographis paniculata, is a cell differentiation inducer. 14-Deoxy-12-methoxyandrographolide induces differentiation of myeloid leukemia cells via increased phagocytosis of polystyrene latex particles. 14-Deoxy-12-methoxyandrographolide can be used for the research of myeloid leukemia .

Yunnancoronarin B	Structural Classification Hedychium gardnerianum Sheppard ex Ker Gawl. Terpenoids Diterpenoids Plants Source Classification Zingiberaceae	Drug Derivative
Yunnancoronarin B is a natural diterpene.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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labdane-type diterpenoid

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Natural
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