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Cat. No.: HY-N19664

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14-Deoxy-12-methoxyandrographolide

14-Deoxy-12-methoxyandrographolide, an ent-labdane-type diterpenoid found in the aerial parts of Andrographis paniculata, is a cell differentiation inducer. 14-Deoxy-12-methoxyandrographolide induces differentiation of myeloid leukemia cells via increased phagocytosis of polystyrene latex particles. 14-Deoxy-12-methoxyandrographolide can be used for the research of myeloid leukemia.

For research use only. We do not sell to patients.

CAS No.: 142036-15-5
Formula: C₂₁H₃₂O₅
Molecular Weight:364.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

14-Deoxy-12-methoxyandrographolide Chemical Structure

CAS No.: 142036-15-5

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

¹⁴Deoxy-12-methoxyandrographolide (Compound 7) (5-50 μM; 48 h) moderately induces differentiation of mouse myeloid leukemia (M1) cells, as measured by phagocytosis of polystyrene latex particles^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Differentiation Assay^[1]

Cell Line:

mouse myeloid leukemia (M1) cells
Concentration:

5 μM; 17 μM; 50 μM
Incubation Time:

48 h
Result:

Showed moderate cell differentiation-inducing activity.
Increased phagocytic ratio in a dose-dependent manner.
Reduced M1 cell number in a dose-dependent manner.

Chemical Information

CAS No. 142036-15-5
Molecular Weight 364.48
Formula C₂₁H₃₂O₅
SMILES

C[C@]12[C@@](CCC([C@H]2C[C@H](C3=CCOC3=O)OC)=C)([H])[C@@](C)([C@@H](CC1)O)CO
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
- Plants
- Acanthaceae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Matsuda T, et al. Cell differentiation-inducing diterpenes from Andrographis paniculata Nees. Chem Pharm Bull (Tokyo). 1994;42(6):1216-1225. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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