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  6. 14-Deoxy-12-methoxyandrographolide

14-Deoxy-12-methoxyandrographolide, an ent-labdane-type diterpenoid found in the aerial parts of Andrographis paniculata, is a cell differentiation inducer. 14-Deoxy-12-methoxyandrographolide induces differentiation of myeloid leukemia cells via increased phagocytosis of polystyrene latex particles. 14-Deoxy-12-methoxyandrographolide can be used for the research of myeloid leukemia.

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14-Deoxy-12-methoxyandrographolide

14-Deoxy-12-methoxyandrographolide Chemical Structure

CAS No. : 142036-15-5

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14-Deoxy-12-methoxyandrographolide Related Antibodies

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Description

14-Deoxy-12-methoxyandrographolide, an ent-labdane-type diterpenoid found in the aerial parts of Andrographis paniculata, is a cell differentiation inducer. 14-Deoxy-12-methoxyandrographolide induces differentiation of myeloid leukemia cells via increased phagocytosis of polystyrene latex particles. 14-Deoxy-12-methoxyandrographolide can be used for the research of myeloid leukemia[1].

In Vitro

14Deoxy-12-methoxyandrographolide (Compound 7) (5-50 μM; 48 h) moderately induces differentiation of mouse myeloid leukemia (M1) cells, as measured by phagocytosis of polystyrene latex particles[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

14-Deoxy-12-methoxyandrographolide Related Antibodies

Cell Differentiation Assay[1]

Cell Line: mouse myeloid leukemia (M1) cells
Concentration: 5 μM; 17 μM; 50 μM
Incubation Time: 48 h
Result: Showed moderate cell differentiation-inducing activity.
Increased phagocytic ratio in a dose-dependent manner.
Reduced M1 cell number in a dose-dependent manner.
Molecular Weight

364.48

Formula

C21H32O5
CAS No.
SMILES

C[C@]12[C@@](CCC([C@H]2C[C@H](C3=CCOC3=O)OC)=C)([H])[C@@](C)([C@@H](CC1)O)CO
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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14-Deoxy-12-methoxyandrographolide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

14-Deoxy-12-methoxyandrographolide142036-15-5Otherspolystyrene latex particlesgrowth inhibitormyeloid leukemia cellscell differentiation inducerphagocytosisent-labdane-type diterpenoidmouse myeloid leukemia (M1) cellsAndrographis paniculataInhibitorinhibitorinhibit

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