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Art. -Nr.: HY-N19664

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14-Deoxy-12-methoxyandrographolide

14-Deoxy-12-methoxyandrographolide, an ent-labdane-type diterpenoid found in the aerial parts of Andrographis paniculata, is a cell differentiation inducer. 14-Deoxy-12-methoxyandrographolide induces differentiation of myeloid leukemia cells via increased phagocytosis of polystyrene latex particles. 14-Deoxy-12-methoxyandrographolide can be used for the research of myeloid leukemia.

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CAS. Nr.: 142036-15-5
Formel: C₂₁H₃₂O₅
Molecular Weight:364.48

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

14-Deoxy-12-methoxyandrographolide Chemical Structure

CAS. Nr.: 142036-15-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Protokoll (2)
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Verweise
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Biologische Aktivität

Beschreibung

In Vitro

¹⁴Deoxy-12-methoxyandrographolide (Compound 7) (5-50 μM; 48 h) moderately induces differentiation of mouse myeloid leukemia (M1) cells, as measured by phagocytosis of polystyrene latex particles^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Cell Differentiation Assay^[1]

View Protocol

Cell Line:

mouse myeloid leukemia (M1) cells
Concentration:

5 μM; 17 μM; 50 μM
Incubation Time:

48 h
Result:

Showed moderate cell differentiation-inducing activity.
Increased phagocytic ratio in a dose-dependent manner.
Reduced M1 cell number in a dose-dependent manner.

Chemical Information

CAS. Nr. 142036-15-5
Molecular Weight 364.48
Formel C₂₁H₃₂O₅
SMILES

C[C@]12[C@@](CCC([C@H]2C[C@H](C3=CCOC3=O)OC)=C)([H])[C@@](C)([C@@H](CC1)O)CO
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Cell Biology

Phagocytosis Functional Assay
A phagocytosis functional assay measures the ability of phagocytic cells, such as neutrophils, macrophages, monocytes, or microglia/macrophages, to bind and internalize particulate targets including bacteria, yeast particles, beads, or myelin particles. Fluorescent flow-cytometry assays detect target uptake as fluorescence associated with gated phagocytes, while pH-sensitive dyes such as pHrodo increase signal in acidic phagosomal compartments and therefore preferentially report internalized particles rather than particles remaining outside the cell. Microscopy or high-content imaging can be used to confirm intracellular localization and, in some protocols, to follow uptake kinetics.
iPSC cell differentiation
Induced pluripotent stem cells (iPSCs) are a type of cell that has similar properties to embryonic stem cells through somatic cell reprogramming.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Matsuda T, et al. Cell differentiation-inducing diterpenes from Andrographis paniculata Nees. Chem Pharm Bull (Tokyo). 1994;42(6):1216-1225. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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14-Deoxy-12-methoxyandrographolide

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14-Deoxy-12-methoxyandrographolide

Biologische Aktivität

Beschreibung

In Vitro

Chemical Information

Protokoll

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

14-Deoxy-12-methoxyandrographolide Related Classifications

HY-N19664 Related Classifications

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