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Results for "

leukocyte elastase

" in MedChemExpress (MCE) Product Catalog:

20

Inhibitors & Agonists

2

Fluorescent Dyes

1

Biochemical Assay Reagents

5

Peptides

3

Recombinant Proteins

1

Antibodies

1

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-136865
    MeOSuc-AAPV-AMC

    		Fluorescent Dye Others
    MeOSuc-AAPV-AMC is a fluorogenic substrate for human leukocyte and porcine pancreatic elastase (Km: 362 μM, Ex=380 nm, Em=460 nm) .
    MeOSuc-AAPV-AMC
  • HY-75957
    DMP 777
    5 Publications Verification

    L-694458

    		 Elastase Inflammation/Immunology
    DMP 777 is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.
    DMP 777
  • HY-P2685
    MeOSuc-Ala-Ala-Pro-Val-pNA

    		Fluorescent Dye Others
    MeOSuc-Ala-Ala-Pro-Val-pNA is a sensitive chromogenic substrate for human leukocyte and porcine pancreatic elastase .
    MeOSuc-Ala-Ala-Pro-Val-pNA
  • HY-103445
    SSR69071

    		Elastase Cardiovascular Disease
    SSR69071 is a potent, orally active and selective inhibitor of neutrophil elastase. SSR69071 reduces myocardial infarct size following ischemia-reperfusion injury . SSR69071 displays a higher affinity for human elastase (Ki=0.0168 nM) than for rat (Ki=3 nM), mouse (Ki=1.8 nM), and rabbit (Ki= 58 nM) elastases .
    SSR69071
  • HY-136888
    MeOSuc-AAPV-CMK

    elastase Inhibitor III

    		 Elastase Cathepsin Others
    MeOSuc-AAPV-CMK (Elastase Inhibitor III) is an elastase inhibitor. MeOSuc-AAPV-CMK also inhibits cathepsin G and proteinase 3.MeOSuc-AAPV-CMK blocks the cleavage of adiponectin by leukocyte elastase .
    MeOSuc-AAPV-CMK
  • HY-19269
    FK706

    		Elastase Inflammation/Immunology
    FK706 is a potent, slow-binding and competitive inhibitor of human neutrophil elastase with an IC50 of 83 nM and a Ki of 4.2 nM. FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase with IC50s of 22 nM and 100 nM, respectively, and has no inhibitory activity against other serine proteinases such as human pancreatic trypsin, human pancreatic α-chymotrypsin and human leukocyte cathepsin G. FK706 has anti-inflammatory effect .
    FK706
  • HY-10242
    Ciluprevir

    BILN 2061; BILN 2061ZW

    		 HCV HCV Protease DNA/RNA Synthesis Infection
    Ciluprevir (BILN 2061; BILN 2061ZW) is an orally active macrocyclic peptide inhibitor of hepatitis C virus (HCV)NS3 protease, with an IC50 of 3 nM. Ciluprevir has Kᵢ values of 0.66 nM and 0.30 nM against genotypes 1b and 1a, respectively. Ciluprevir inhibits HCV RNA replication with an EC50 of 1.2 nM, and its EC50 values against genotypes 1b and 1a are 3 nM and 4 nM, respectively. Ciluprevir shows no significant inhibition against human leukocyte elastase and hepatic cathepsin B. Ciluprevir can be used for genotype 1 HCV infection .
    Ciluprevir
  • HY-W008753
    Z-L-Val-OH

    N-Cbz-L-valine

    		 Biochemical Assay Reagents Drug Intermediate Amino Acid Derivatives Infection
    Z-L-Val-OH (N-Cbz-L-valine) is an amino acid derivative and key intermediate in organic synthesis. Z-L-Val-OH can be used in the synthesis of anti-cytomegalovirus compounds and peptide inhibitors of human spleen plasminogen activator (SFP) and human leukocyte elastase-like protease (ELP) .
    Z-L-Val-OH
  • HY-105382
    L 683845

    		Others Others
    L-683845 is an orally active inhibitor of human leukocyte elastase. L-683845 can be used in the research of physiological and pathological processes related to human leukocyte elastase .
    L 683845
  • HY-P4126
    Suc-Ala-Ala-Pro-Val-AMC

    		Elastase Others
    Suc-Ala-Ala-Pro-Val-AMC is a fluorescent substrate for elastase. Suc-Ala-Ala-Pro-Val-AMC can be hydrolyzed by these elastases to release the fluorescent substance 7-amino-4-methylcoumarin. Suc-Ala-Ala-Pro-Val-AMC is used for in vitro elastase activity assays and can also be applied in studies related to chronic wounds .
    Suc-Ala-Ala-Pro-Val-AMC
  • HY-106899
    MK 287

    		Platelet-activating Factor Receptor (PAFR) Cardiovascular Disease
    MK 287 is a potent, selective and orally active antagonist of platelet-activating factor receptor (PAFR). MK 287 can inhibit [3H]C18-PAF binding to human platelet, polymorphonuclear leukocyte (PMN) and lung membranes with K1 values of 6.1, 3.2, and 5.49 nM, respectively. MK 287 can inhibit PAF-induced aggregation of platelets in plasma or gel-filtered platelets and elastase release from PMNs with ED50 values of 56, 1.5 and 4.4 nM. MK 287 can be used for the research of cardiovascular disease, such as thrombosis .
    MK 287
  • HY-118621
    JCP174

    		Elastase Parasite Infection
    JCP174 is an inhibitor of palmitoyl protein thioesterase-1 (TgPPT1), a depalmitoylase in the parasite T. gondii . JCP174 is also an inhibitor of porcine pancreatic elastase and human leukocyte elastase .
    JCP174
  • HY-120876
    L-680833

    		Beta-lactamase Elastase Inflammation/Immunology
    L-680833 is a monocyclic β-lactam inhibitor of human polymorphonuclear leukocyte elastase (PMNE) inhibitor. L-680833 can be used for the study of PMNE-damaged tissue diseases .
    L-680833
  • HY-118261
    L 659286

    		Elastase Inflammation/Immunology
    L 659286 is an inhibitor of human polymorphonuclear leukocyte elastase (PMN elastase) (Ki=0.4 μM). Intratracheal injection of L 659286 can induce lung injury in hamsters.
    L 659286
  • HY-138570
    HLE-IN-1

    		Elastase Inflammation/Immunology
    HLE-IN-1 (Compound 4) is a human leukocyte elastase HLE inhibitor (Ki=1.8 nM). HLE-IN-1 is used in emphysema and inflammamry pulmonary research .
    HLE-IN-1
  • HY-117591
    L 684248

    		Elastase Inflammation/Immunology Cancer
    L-684248 is an inhibitor of human leukocyte elastase (HLE). L-684248 exerts its inhibitory effect on HLE by forming a covalent bond with the active site of the enzyme, showing potential value for applications in anti-inflammatory and anti-tumor research .
    L 684248
  • HY-174540
    Human SERPINA1 mRNA

    		mRNA Cancer
    Human SERPINA1 mRNA encodes the human serpin family A member 1 (SERPINA1) protein, a serine protease inhibitor belonging to the serpin superfamily. SERPINA1’s major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).
    Human SERPINA1 mRNA
  • HY-117811
    (R,R)-MK 287

    L-680574

    		 Platelet-activating Factor Receptor (PAFR) Cardiovascular Disease
    (R,R)-MK 287 (L-680574) is a tetrahydrofuran derivative that potently inhibits the binding of [3H]C18-PAF to human platelets, polymorphonuclear leukocytes (PMNs), and lung membranes with Ki values of 6.1, 3.2, and 5.49 nM, respectively. (R,R)-MK 287 potently and selectively inhibits PAF-induced platelet aggregation (ED50=56 nM) and elastase release from PMNs (ED50=4.4 nM). (R,R)-MK 287 inhibits PAF-induced lethality in mice (ED50=0.8 mg/kg, po) and PAF-induced bronchospasm in guinea pigs (ED50=0.18 mg/kg) .
    (R,R)-MK 287
  • HY-106899A
    (rel)-MK 287

    (rel)-L-680573

    		 Platelet-activating Factor Receptor (PAFR) Others
    (rel)-MK 287 ((rel)-L-680573) is a relative configuration of MK 287. MK 287 is a potent, selective and orally active antagonist of platelet-activating factor receptor (PAFR). MK 287 can inhibit [3H]C18-PAF binding to human platelet, polymorphonuclear leukocyte (PMN) and lung membranes with K1 values of 6.1, 3.2, and 5.49 nM, respectively. MK 287 can inhibit PAF-induced aggregation of platelets in plasma or gel-filtered platelets and elastase release from PMNs with ED50 values of 56, 1.5 and 4.4 nM. MK 287 can be used for the research of cardiovascular disease, such as thrombosis .
    (rel)-MK 287
  • HY-P11787
    Eglin c (60-63)

    		Elastase Inflammation/Immunology
    Eglin c (60-63) is a selective Elastase inhibitor, with a Ki value of 2.3e-3 M against human leukocyte hElastase and a Ki value of 4.8e-3 M against porcine pancreatic Elastase. Eglin c (60-63) can be used in research related to rheumatoid arthritis .
    Eglin c (60-63)

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