11 Results for "

lipoxin A4

" in MedChemExpress (MCE) Product Catalog:
Products (11)

11 Results for "lipoxin A4" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-113509
CAS No.: 89663-86-5
Purity:  98.0%
Synonyms: LXA4
Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties . Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways . Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC50 value of 25.74 nM .
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1
1 Cited Publications
Cat. No.: HY-100450
CAS No.: 78606-80-1
Purity:  ≥98.0%
BML-111, a lipoxin A4 analog, is a lipoxin A4 receptor agonist. BML-111 represses the activity of angiotensin converting enzyme (ACE) and increases the activity of angiotensinconverting enzyme 2 (ACE2). BML-111 has antiangiogenic, antitumor and anti-inflammatory properties .
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Cat. No.: HY-124071
CAS No.: 1258417-54-7
Purity:  99.96%
Research Areas:  

Inflammation/Immunology

ACT-389949 is a first-in-class, potent and selective and agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes. ACT-389949 has potential for the treatment of inflammatory disorders .
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Cat. No.: HY-113509B
CAS No.: 171030-11-8
Synonyms: 15-epi-LXA4
15 (R)-Lipoxin A4 (15-epi-LXA4) is a specialized pro-resolving mediator and an acetylated derivative of COX2. 15 (R)-Lipoxin A4 is present in neurons. 15 (R)-Lipoxin A4 induces the SPM synthases ALOX12 and ALOX15, as well as the pro-resolving receptor ALX. 15 (R)-Lipoxin A4 inhibits protein kinases, including JNK1/2/3, Lyn, STAT-3 and STAT-6. 15 (R)-Lipoxin A4 enhances the release of pro-resolving mediators. 15 (R)-Lipoxin A4 alleviates the pro-inflammatory phenotype of tendon-derived stromal cells. 15 (R)-Lipoxin A4 promotes the resolution of neuroinflammation. 15 (R)-Lipoxin A4 is applicable to research related to achilles tendinitis, achilles tendon rupture and Alzheimer’s disease .
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Cat. No.: HY-126722
CAS No.: 97643-35-1
Research Areas:  

Inflammation/Immunology

Lipoxin A4 methyl ester is a stable synthetic analog of lipoxin with anti-inflammatory properties that can be extracted from arachidonic acid .
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Cat. No.: HY-113509S
CAS No.: 1622429-53-1
Synonyms: LXA4-d5
Lipoxin A4-d5 is the deuterium labeled Lipoxin A4. Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties . Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways . Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC50 value of 25.74 nM .
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Cat. No.: HY-113509A
CAS No.: 94292-80-5
Synonyms: 6-epi-LXA4
Target:  

Drug Derivative

Research Areas:  

Others

6-epi-Lipoxin A4 is an active compound.
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Cat. No.: HY-112621
CAS No.: 73466-12-3
Synonyms: LTA4 methyl ester
Research Areas:  

Inflammation/Immunology

Leukotriene A4 methyl ester (LTA4 methyl ester) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA4 synthase activities. LTA4 is rapidly metabolized by LTA4 hydrolase or LTC4 synthase to LTB4 or LTC4, respectively. LTA4, from leukocytes, is known to undergo transcellular metabolism in platelets, erythrocytes, and endothelial cells. Further metabolism of LTA4 by 15-LO leads to lipoxin biosynthesis. LTA4 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed.
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Cat. No.: HY-100450R
CAS No.: 78606-80-1
BML-111 (Standard) is the analytical standard of BML-111 (HY-100450). This product is intended for research and analytical applications. BML-111, a lipoxin A4 analog, is a lipoxin A4 receptor agonist. BML-111 represses the activity of angiotensin converting enzyme (ACE) and increases the activity of angiotensinconverting enzyme 2 (ACE2). BML-111 has antiangiogenic, antitumor and anti-inflammatory properties .
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Cat. No.: HY-P705632
Purity:  ≥ 85%, as determined by reducing SDS-PAGE .
Synonyms: FPR2; FPRH2; Prev. FPRL1; FPR2A; Formyl Peptide Receptor-Like 1; ALXR; N-Formyl Peptide Receptor 2; lipoxin A4 Receptor; LXA4R; LXA4 Receptor; HM63; FMLP-R-I; ALX; FPRH1; FMLP-Related Receptor I; RFP; FMLP-R-II; lipoxin A4 Receptor (Formyl Peptide Recepto
Species:  
Source:  
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Cat. No.: HY-P89830
Synonyms: FPRH1, FPRL1, LXA4R, FPR2, N-formyl peptide receptor 2, FMLP-related receptor I, Formyl peptide receptor-like 1, HM63, lipoxin A4 receptor, RFP, FMLP-R-I, LXA4 receptor

Host:  

Mouse

Application:  

WB, IP, FC

Reactivity:  

human

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