89663-86-5
Chemical Structure
Lipoxin A4
Synonym(s): LXA4
- CAS No.: 89663-86-5
- Formula:C20H32O5
- Molecular Weight:352.47
IUPAC Name: (5S,6R,7E,9E,11Z,13E,15S)-5,6,15-trihydroxyicosa-7,9,11,13-tetraenoic acid
InChIKey: IXAQOQZEOGMIQS-SSQFXEBMSA-N
SMILES: CCCCC[C@H](O)/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)CCCC(O)=O
Biological Activity:
Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties[1]. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways[2]. Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC50 value of 25.74 nM[3].
The product specifications provided below refer solely to the active content of Lipoxin A4.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Lipoxin A4 | 98.0% | Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways. Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC50 value of 25.74 nM. The product specifications provided below refer solely to the active content of Lipoxin A4. |
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Lipoxin A4-d5 | Lipoxin A4-d5 is the deuterium labeled Lipoxin A4. Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways. Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC50 value of 25.74 nM. | |||||||||||||||||||||
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Similarity Score 1.00
HY-113509A6-epi-Lipoxin A4 -
Similarity Score 1.00
HY-113509B15(R)-Lipoxin A4 -
Similarity Score 0.98
HY-116953Lipoxin B4 -
Similarity Score 0.90
HY-126722Lipoxin A4 methyl ester -
Similarity Score 0.88
HY-134123Lipoxin B4 methyl ester -
Similarity Score 0.84
HY-115381Lipoxin A5 -
Similarity Score 0.84
HY-168782Resolvin D2 n-3 DPA -
Similarity Score 0.80
HY-130138(5S,6S)-DiHETE -
Similarity Score 0.80
HY-130138A(5S,6R)-DiHETE -
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References
- [1]. Feng Hu, et al. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes associated with the ERK1/2 and NF-κB pathways. J Dermatol Sci. 2015 Jun;78(3):181-8. [Content Brief]
- [2]. Steven Bozinovski, et al. Serum amyloid A opposes lipoxin A₄ to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):935-40. [Content Brief]
- [3]. Xinxin Liu, et al. Lipoxin A4 and its analog suppress inflammation by modulating HMGB1 translocation and expression in psoriasis.Sci Rep. 2017 Aug 2;7(1):7100. [Content Brief]
