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nanog

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) E1/E2/E3 Enzyme (1) Histone Demethylase (1) HSP (1) MDM-2/p53 (1) Microtubule/Tubulin (1) mRNA (1) Oct3/4 (5) Proteasome (1) RAR/RXR (1) Reactive Oxygen Species (ROS) (1) Small Interfering RNA (siRNA) (3) STAT (1) TET Protein (1)
By Research Areas:	Cancer (9) Inflammation/Immunology (1) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Transcription Factors (1) mRNA (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12303

OAC1 1 Publications Verification	Oct3/4 TET Protein	Cancer
OAC1 is a potent Oct4 activator. OAC1 activates Oct4 and Nanog promoters and enhances induced pluripotent stem cells (iPSC) formation. OAC1 activates OCT4 through upregulation of HOXB4 expression. OAC1 increases transcription of the Oct4-Nanog-Sox2 triad and TET1. OAC1 facilitates the reprogramming of cells by enhancing efficiency and shortening the reprogramming time .

HY-18772

O4I2	Oct3/4	Others
O4I2 is a potent Oct3/4 inducer. O4I2 induces the expression of pluripotent-associated genes Lin28, Sox2 and Nanog, and suppresses Rex1 .

HY-17602

Amcasertib BBI503	Apoptosis	Cancer
Amcasertib (BBI503) is an orally activate cancer stemness kinase inhibitor that enhances apoptosis. Amcasertib inhibits the expression of *NANOG* and CD133 and cell viability in PC-9/GR cells.

HY-168566

EV206	HSP	Cancer
EV206 is a Hsp70 binder and apoptosis inducer that binds to the N-terminal domain of Hsp70, promotes Hsp70 degradation via the ubiquitin-proteasome system, and reduces Hsp70 protein stability. EV206 induces apoptotic cell death, inhibits colony formation, and downregulates the expression of cancer stem cell-related markers in non-small cell lung cancer cells. EV206 inhibits the growth of H460 xenograft tumors in nude mice and can be used for the research of non-small cell lung cancer .

HY-119672

Oct4 inducer-1	Oct3/4	Others
Oct4 inducer-1 (compound OAC-3) is a potent Oct4 activator. Oct4 inducer-1 activates Oct4 and Nanog promoters and enhances induced pluripotent stem cells (iPSC) formation. Oct4 inducer-1 facilitates the reprogramming of cells by enhancing efficiency and shortening the reprogramming time .

HY-179339

LSD1-IN-46	Histone Demethylase	Cancer
LSD1-IN-46 is a potent and orally active Lysine-specific demethylase 1 (LSD1) inhibitor with an IC₅₀ of 0.082 μM. LSD1-IN-46 interrupts the β-catenin-mediated transcriptional program, thereby suppressing the stemness of gastric cancer cells. LSD1-IN-46 exhibits strong anti-tumor activity. LSD1-IN-46 can be used for the research of gastric cancer .

HY-174574

*Human NANOG* mRNA**	mRNA	Cancer
Human NANOG mRNA encodes the human Nanog homeobox (NANOG) protein, a DNA binding homeobox transcription factor that involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. NANOG can block ES cell differentiation and autorepress its own expression in differentiating cells.

HY-N15201

Betavulgarin	STAT	Cancer
Betavulgarin is an anticancer agent. Betavulgarin can be isolated from Sugar Beet (Beta vulgaris). Betavulgarin suppresses the proliferation, migration, colony formation, and mammosphere formation of breast cancer cells, and reduces the size of the CD44 ⁺/CD24 ⁻ subpopulation and the expression of the self-renewal- related genes C-Myc, Nanog and Oct4. Betavulgarin promotes BCSCs death through the regulation of Stat3/Sox2 signaling .

HY-RS09019

NANOG Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NANOG Human Pre-designed siRNA Set A contains three designed siRNAs for NANOG gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NANOG Human Pre-designed siRNA Set A NANOG Human Pre-designed siRNA Set A

HY-RS19720

Nanog Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nanog Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nanog gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nanog Mouse Pre-designed siRNA Set A Nanog Mouse Pre-designed siRNA Set A

HY-RS26216

Nanog Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nanog Rat Pre-designed siRNA Set A contains three designed siRNAs for Nanog gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nanog Rat Pre-designed siRNA Set A Nanog Rat Pre-designed siRNA Set A

HY-129108

9-cis-UAB30 (9Z)-UAB-30	Oct3/4 Microtubule/Tubulin E1/E2/E3 Enzyme Proteasome	Neurological Disease Cancer
9-cis-UAB30 is a rexinoid agonist. 9-cis-UAB30 significantly decreases the proliferation, viability, and motility of both patient-derived xenografts (PDXs). 9-cis-UAB30 induced cell-cycle arrest as demonstrated by the significant increase in the percentage of cells in G1 and a decrease in the percentage of cells in S phase by downregulating SKP2 and/or 20S proteasome activity, which leads to increased p27kip1 protein stability. 9-cis-UAB30 downregulates the abundance of stem cell marker mRNAs (Oct4, Nanog, Sox2, nestin) and upregulates the abundance of differentiation marker mRNAs (β3-tubulin, NSE, HOXC9, GAP43). 9-cis-UAB30 has no adverse effects on the central nervous system and cardiovascular system at the tested dose. 9-cis-UAB30 can be used for the study of neuroblastoma, cutaneous T-cell lymphomas, and breast cancer .

HY-168885

ZSH-512	Apoptosis RAR/RXR	Cancer
ZSH-512 is a potent RARγ inhibitor. ZSH-512 shows antiproliferation activity. ZSH-512 induces apoptosis. ZSH-512 decreases CD133, NANOG, SOX2, and EPCAM protein expression. ZSH-512 shows anticancer activity. ZSH-512 has the potential for the research of colorectal cancer .

HY-119666

Rooperol	Apoptosis Reactive Oxygen Species (ROS) MDM-2/p53 Oct3/4	Inflammation/Immunology Cancer
Rooperol is a norlignan analog with antitumor, anti-inflammatory, and antioxidant activities. Rooperol induces apoptosis in CSCs through a mitochondrial-induced increase in ROS and a p53-dependent pathway, while also downregulating the expression of key stem cell regulatory factors, such as Oct4, *Nanog, and Sox2*, ultimately exerting its anticancer effects .

Cat. No.	Product Name

HY-K6019

Stem Cell Cryopreservation Medium
90%) and stable expression of pluripotency markers such as OCT4 and NANOG, providing consistent and reliable cell sources for subsequent expansion and differentiation. This product is suitable for long-term, stable storage of PSCs and downstream applications.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N15201

Betavulgarin	Structural Classification Flavonoids Beta vulgaris Linn. Plants Isoflavones Chenopodiaceae Source Classification	STAT
Betavulgarin is an anticancer agent. Betavulgarin can be isolated from Sugar Beet (Beta vulgaris). Betavulgarin suppresses the proliferation, migration, colony formation, and mammosphere formation of breast cancer cells, and reduces the size of the CD44 ⁺/CD24 ⁻ subpopulation and the expression of the self-renewal- related genes C-Myc, Nanog and Oct4. Betavulgarin promotes BCSCs death through the regulation of Stat3/Sox2 signaling .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P7391

	NANOG Protein, Human (His-SUMO) rHunanog-TAT; Homeobox protein nanog	Human	E. coli
	NANOG Protein, Human (His-SUMO) which functions to maintain the undifferentiated state of pluripotent stem cells.

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Host:	Mouse (2) Rabbit (3)
Reactivity:	Human (5) Rat (1) Mouse (2)
Application:	IHC-P (3) ICC/IF (5) IF-Tissue (1) IP (1) IHC-F (1) WB (5) FC (1) ELISA (3)
Isotype:	IgG (3) IgG1 (2)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (3) Monoclonal Antibody (1) Recombinant (2)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84804

	Nanog Antibody (YA4501) nanog	WB, ICC/IF, ELISA	Human
	Nanog Antibody (YA4501) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Nanog.

HY-P84804A

	Nanog Antibody (YA4501)(PBS only) nanog	WB, ICC/IF, ELISA	Human
	Nanog Antibody (YA4501) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Nanog.

HY-P85292

	Nanog Antibody (YA4984) nanog; Homeobox protein nanog; Homeobox transcription factor nanog; hnanog	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue	Human, Mouse, Rat
	Nanog Antibody (YA4984) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Nanog.

HY-P86599

	Nanog Antibody (YA6291) nanog; Homeobox protein nanog; Homeobox transcription factor nanog; hnanog	WB, IHC-P, ICC/IF, IP, ELISA	Human
	Nanog Antibody (YA6291) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nanog.

HY-P80237

	Nanog Antibody (YA275) 1 Publications Verification	WB, ICC/IF, FC, IHC-P	Human, Mouse
	Nanog Antibody (YA275) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nanog.