83644-00-2
83644-00-2
Chemical Structure
Rooperol
- CAS No.: 83644-00-2
- Formula:C17H14O4
- Molecular Weight:282.29
IUPAC Name: (E)-4,4'-(pent-1-en-4-yne-1,5-diyl)bis(benzene-1,2-diol)
InChIKey: JQPOMMNEABQHEU-DUXPYHPUSA-N
SMILES: OC1=CC=C(C=C1O)/C=C/CC#CC2=CC=C(C(O)=C2)O
Biological Activity: Rooperol is a norlignan analog with antitumor, anti-inflammatory, and antioxidant activities. Rooperol induces apoptosis in CSCs through a mitochondrial-induced increase in ROS and a p53-dependent pathway, while also downregulating the expression of key stem cell regulatory factors, such as Oct4, Nanog, and Sox2, ultimately exerting its anticancer effects[1][2][3][4].
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Rooperol | Rooperol is a norlignan analog with antitumor, anti-inflammatory, and antioxidant activities. Rooperol induces apoptosis in CSCs through a mitochondrial-induced increase in ROS and a p53-dependent pathway, while also downregulating the expression of key stem cell regulatory factors, such as Oct4, Nanog, and Sox2, ultimately exerting its anticancer effects. | |||||||||||||||||||||
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References
- [1]. Boukes G J, et al. Rooperol as an antioxidant and its role in the innate immune system: An in vitro study[J]. Journal of ethnopharmacology, 2012, 144(3): 692-699. [Content Brief]
- [2]. Kabanda M M. Antioxidant activity of rooperol investigated through Cu (I and II) chelation ability and the hydrogen transfer mechanism: a DFT study[J]. Chemical research in toxicology, 2012, 25(10): 2153-2166. [Content Brief]
- [3]. Guzdek A, et al. Rooperol, an inhibitor of cytokine synthesis, decreases the respiratory burst in human and rat leukocytes and macrophages[J]. Mediators of Inflammation, 1997, 6(1): 53-57. [Content Brief]
- [4]. Ali Azouaou S, et al. Selective ROS-dependent p53-associated anticancer effects of the hypoxoside derivative rooperol on human teratocarcinomal cancer stem-like cells[J]. Investigational New Drugs, 2015, 33: 64-74. [Content Brief]
