52 Results for "

neoplasm

" in MedChemExpress (MCE) Product Catalog:
Products (52)

52 Results for "neoplasm" in MCE Product Catalog:

4
Isomangiferin
Isomangiferin
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4 Cited Publications
Cat. No.: HY-N0772
CAS No.: 24699-16-9
Category:  

Infection Liliaceae Xanthones Phenols Polyphenols Anemarrhena asphodeloides Bunge Plants Disease Research Fields

Target:  

VEGFR NOD-like Receptor (NLR) NF-κB Bacterial AMPK Acetyl-CoA Carboxylase Apoptosis Reactive Oxygen Species (ROS) HSV Drug Derivative

Isomangiferin is an orally active xanthone C-glucoside, and its chemical structure is similar to Mangiferin (HY-N0290). Isomangiferin is an effective VEGFR-2 kinase inhibitor, which can induces cell apoptosis, inhibit the growth, metastasis and angiogenesis of breast cancer. Isomangiferin exerts anti-inflammatory effects by inhibiting the HMGB1/NLRP3/NF-κB signaling pathway, thereby improving the renal function indicators of diabetic mice. Isomangiferin exhibits inhibitory effects on various bacteria and herpes simplex virus type 1 (HSV-1). Isomangiferin promotes the migration and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and reduces cell apoptosis and the production of ROS by activating the AMPK/ACC pathway, thereby facilitating fracture healing .
3
Flucytosine
Flucytosine
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3 Cited Publications
Cat. No.: HY-B0139
CAS No.: 2022-85-7
Synonyms: 5-Fluorocytosine; NSC 103805; Ro 2-9915
Target:  

Fungal Antibiotic

Research Areas:  

Infection Cancer

Flucytosine (5-Fluorocytosine) is an antifungal compound with oral activity. Flucytosine is a widely used cytotoxic drug that, after further metabolism, produces fluorinated ribonucleotides and deoxyribonucleotides, inhibits DNA and protein synthesis, and has multiple effects such as inhibiting candida and candida neoplasm infection and producies cytotoxicity to cancer cells .
2
2-Hydroxyhexanoic acid
2-Hydroxyhexanoic acid
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2 Cited Publications
Cat. No.: HY-75954
CAS No.: 6064-63-7
Category:  

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

2-Hydroxyhexanoic acid is a metabolite. 2-Hydroxyhexanoic acid is elevated in metastatic pancreatic neuroendocrine tumors. 2-Hydroxyhexanoic acid does not promote the proliferation, migration or invasion of pancreatic neuroendocrine tumor cells. 2-Hydroxyhexanoic acid can be used in the research of metastatic pancreatic neuroendocrine tumors .
Toripalimab
Toripalimab
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Cat. No.: HY-P9978
CAS No.: 1924598-82-2
Synonyms: JS-001

Target:  

PD-1/PD-L1

Research Areas:  

Cancer

Toripalimab is a selective, recombinant, humanized monoclonal antibody against PD-1. Toripalimab is able to bind to PD-1 and block the interaction with its ligands. Toripalimab has exhibited primary anti-tumor effects in tumors such as melanoma, lung cancer, digestive tract tumors, hepatobiliary and pancreatic tumors, neuroendocrine neoplasms, nasopharyngeal carcinoma and urothelial carcinoma .
Pivekimab
Pivekimab
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Cat. No.: HY-P99234
CAS No.: 2234335-84-1

Target:  

Interleukin Related ADC Antibodies

Research Areas:  

Cancer

Pivekimab is a human IgG1 monoclonal antibody that targets interleukin-3 (IL-3) and CD123. Pivekimab is used to synthesize pivekimab sunirine, a CD123-directed antibody-active molecule conjugate (ADC). Pivekimab is used in the study of blastic plasmacytoid dendritic cell neoplasm (BPDCN) .
ZT55
ZT55
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Cat. No.: HY-124727
CAS No.: 2138488-38-5
Purity:  99.51%
Target:  

JAK Apoptosis

Research Areas:  

Cancer

ZT55 is an orally active and highly-selective JAK2 inhibitor with an IC50 value of 0.031 μM. ZT55 inhibits the proliferation of JAK2 V617F-expressing HEL cell lines and induces apoptosis and cycle arrest. ZT-55 also effectively inhibits the growth of HEL xenograft tumours in a mice model. ZT-55 can be used in studies of myeloproliferative neoplasms, polycythemia vera and primary thrombocythemia .
Trilaurin
Trilaurin
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Cat. No.: HY-126573
CAS No.: 538-24-9
Purity:  ≥98.0%
Category:  

Endogenous metabolite Disease Research Fields Lipid Cancer

Target:  

Endogenous Metabolite Biochemical Assay Reagents

Trilaurin is an orally active triglyceride. Trilaurin inhibits DMBA-induced, croton oil-promoted skin tumor formation in Swiss Webster mice. Trilaurin increases plasma high-density lipoprotein cholesterol and apolipoprotein A-I concentrations. Trilaurin is used as an occlusive skin conditioning agent and/or non-aqueous thickener in cosmetics .
BMS-986497
BMS-986497
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Cat. No.: HY-171792
Synonyms: ORM-6151
Target:  

Transmembrane Glycoprotein

Research Areas:  

Cancer

BMS-986497 (ORM-6151) is a CD33-targeting antibody-conjugated GSPT1 degrader. BMS-986497 delivers the GSPT1 degrader SMol006 to CD33-expressing cells and induces GSPT1 protein degradation. BMS-986497 shows potential for research on acute myeloid leukemia (AML) .
SGR-1505
SGR-1505
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Cat. No.: HY-160698
CAS No.: 2661481-41-8
Target:  

MALT1 Apoptosis

Research Areas:  

Cancer

SGR-1505 is an oral small molecule MALT1 inhibitor with anti-proliferative and antitumor activity.SGR-1505 inhibits MALT1 enzymatic activity to modulate NF-κB pathway gene expression.SGR-1505 induces modulation of cell cycle, DNA damage, and apoptosis-related genes in in vivo tumor samples.SGR-1505 exerts tumorostatic and regressive activity in ABC-DLBCL xenograft models.SGR-1505 can be used for the research of activated B cell-like diffuse large B cell lymphoma, non-Hodgkin B-cell lymphomas, chronic lymphocytic leukemia, and mature B cell neoplasms .
Imetelstat
Imetelstat
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Cat. No.: HY-12854
CAS No.: 868169-64-6
Purity:  99.43%
Synonyms: GRN163L
Target:  

Telomerase Apoptosis

Research Areas:  

Cardiovascular Disease Cancer

Imetelstat (GRN163L) is a 13-mer oligonucleotide and competitive Telomerase inhibitor. Imetelstat binds with high affinity to the template region of the RNA component of human telomerase. Imetelstat induces Apoptosis. Imetelstat is capable of selectively eliminating myelofibrosis hematopoietic stem cells. Imetelstat leads to the loss of a cancer cell's ability to maintain telomere length, resulting in the inhibition of cell proliferation .
Ropeginterferon alfa-2b
Ropeginterferon alfa-2b
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Cat. No.: HY-P99348
CAS No.: 1335098-50-4
Synonyms: Ropeginterferon alfa-2b-njft; PEG-proline-interferon alpha-2b

Target:  

Apoptosis

Research Areas:  

Cancer

Ropeginterferon alfa-2b (Ropeginterferon alfa-2b-njft) is a monopegylated IFN-α that can be used for the research of myeloproliferative neoplasms .
JAK2 JH2 binder-1
JAK2 JH2 binder-1
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Cat. No.: HY-146186
CAS No.: 2923309-41-3
Purity:  95.47%
Target:  

JAK

Research Areas:  

Cancer

JAK2 JH2 binder-1 (compound 11) is a potent and selective JAK2 JH2 binder, with a Kd of 37.1 nM. JAK2 JH2 binder-1 has the potential for various myeloproliferative neoplasms research .
PFI-6
PFI-6
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Cat. No.: HY-155412
CAS No.: 2675452-91-0
Purity:  ≥99.0%
Target:  

Epigenetic Reader Domain

Research Areas:  

Cancer

PFI-6 is a selective MLLT1 and MLLT3 YEATS domain probe with IC50 values of 0.14 μM and 0.16 μM, respectively. PFI-6 is applicable for cancer research .
Tubeimoside II
Tubeimoside II
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Cat. No.: HY-N0891
CAS No.: 115810-12-3
Synonyms: Tubeimoside-B
Category:  

Triterpenes other families Terpenoids Plants Disease Research Fields Cancer

Target:  

EGFR TGF-β Receptor RIG-I-like receptor (RLR) SARS-CoV

Tubeimoside II is an orally active triterpenoid saponin and antiviral agent that binds to PACT/PRKRA with Kd values of 5.37 μM and 133.1 μM, respectively. Tubeimoside II inhibits oxidase-dependent EGFR activation and reduces TGF-β1-induced oxidative stress. Tubeimoside II activates the RIG-I signaling pathway and increases IFN-β secretion. Tubeimoside II suppresses TPA-induced ear edema, mouse sarcoma 180 growth, and TPA-induced skin tumor formation. Tubeimoside II exerts broad-spectrum antiviral activity against SARS-CoV-2, HCoV-OC43, and IAV-H1N1/FM1. Tubeimoside II can be used in research related to retinoblastoma, respiratory viral infections, skin tumors, and sarcoma 180 .
Pipobroman
Pipobroman
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Cat. No.: HY-16398
CAS No.: 54-91-1
Target:  

DNA Alkylator/Crosslinker DNA/RNA Synthesis

Research Areas:  

Cancer

Pipobroman is a bromide derivative of piperazine and acts as an alkylating agent. Pipobroman plays its role by inhibiting DNA and RNA polymerase or by reducing pyrimidine nucleotide incorporation into DNA. Pipobroman can be used for the cancer research, including polycythemia vera, myeloproliferative neoplasm, and AML et.al .
JAK2-IN-10
JAK2-IN-10
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Cat. No.: HY-161684
CAS No.: 3035735-18-0
JAK2-IN-10 is a selective JAK2 V617F inhibitor with an IC50 value of ≤10 nM . JAK2-IN-10 can be used for the research of myeloproliferative neoplasms and other related diseases .
JAK2-IN-14
JAK2-IN-14
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Cat. No.: HY-175684
CAS No.: 3087335-24-5
Target:  

JAK STAT Apoptosis

Research Areas:  

Cancer

JAK2-IN-14 is an orally active JAK2 inhibitor with an IC50 of 2 nM. JAK2-IN-14 demonstrates 89.5-, 80.5-, and 51-fold selectivity over JAK1, JAK3, and TYK2, respectively. JAK2-IN-14 inhibits STAT5 signaling pathway. JAK2-IN-14 causes tumor cell cycle arrest and apoptosis. JAK2-IN-14 can used for the study of myeloproliferative neoplasms (MPNs) .
Arylsulfatase
Arylsulfatase
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Cat. No.: HY-172404
CAS No.: 9016-17-5
Target:  

Endogenous Metabolite

Research Areas:  

Cancer

Arylsulfatase is a hydrolase with substrate specificity for potassium 6-benzoyl-2-naphthyl sulfate. Arylsulfatase exhibits optimal activity at 37°C, and its incubation time is tissue-dependent. Arylsulfatase can be used in tumor-related research .
Diatrizoate meglumine
Diatrizoate meglumine
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Cat. No.: HY-B0926B
CAS No.: 131-49-7
Synonyms: N-Methyl-D-glucamine diatrizoate
Diatrizoate meglumine (N-Methyl-D-glucamine diatrizoate) is an orally active, water-soluble, poorly absorbable iodinated contrast agent. Diatrizoate meglumine is widely used as an adjuvant for radiological diagnosis and can also be applied to studies of small bowel obstruction in non-malignant conditions .
Spartalizumab
Spartalizumab
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Cat. No.: HY-P9972
CAS No.: 1935694-88-4
Synonyms: PDR001

Target:  

PD-1/PD-L1 IFNAR

Research Areas:  

Cancer

Spartalizumab is a humanized PD-1 IgG4 monoclonal antibody, with a Kd of 0.83 nM for human PD-1 and a Kd of 0.93 nM for cynomolgus monkey PD-1. Spartalizumab binds to PD-1 and blocks its interaction with the ligands PD-L1 and PD-L2. Spartalizumab induces increased IFNγ release. Spartalizumab can be used in the research of anaplastic thyroid carcinoma (ATC) and neuroendocrine neoplasms (NENs) .
Assay Types