2. Metabolic Enzyme/Protease Others
  3. Endogenous Metabolite Biochemical Assay Reagents
  4. Trilaurin

Trilaurin is an orally active triglyceride. Trilaurin inhibits DMBA-induced, croton oil-promoted skin tumor formation in Swiss Webster mice. Trilaurin increases plasma high-density lipoprotein cholesterol and apolipoprotein A-I concentrations. Trilaurin is used as an occlusive skin conditioning agent and/or non-aqueous thickener in cosmetics.

For research use only. We do not sell to patients.

Trilaurin

Trilaurin Chemical Structure

CAS No. : 538-24-9

Size Price Stock Quantity
100 mg In-stock
500 mg In-stock
1 g In-stock
5 g   Get quote  
10 g   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Trilaurin:

Trilaurin Related Antibodies

Top Publications Citing Use of Products

View All Endogenous Metabolite Isoform Specific Products:

View All Isoforms
Human Endogenous Metabolite Microbial Metabolite

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Trilaurin is an orally active triglyceride. Trilaurin inhibits DMBA-induced, croton oil-promoted skin tumor formation in Swiss Webster mice. Trilaurin increases plasma high-density lipoprotein cholesterol and apolipoprotein A-I concentrations. Trilaurin is used as an occlusive skin conditioning agent and/or non-aqueous thickener in cosmetics[1].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Trilaurin does not inhibit 5α-reductase activity in prostate tissue samples[1].
Trilaurin (4 mg per plate) shows no mutagenicity in *Salmonella typhimurium* strains TA1535, TA100, TA1537, TA1538, or TA98 with or without metabolic activation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Trilaurin Related Antibodies
In Vivo

Trilaurin (6.5% w/w; oral administration; mixed into feed; 4 days, 1 week) increases plasma HDL cholesterol and apolipoprotein A-I (apo A-I) concentrations in WHHL rabbits and NZW rabbits, and this effect is reversible after discontinuation[1].
Trilaurin (3 times per week; for 20 weeks) completely inhibits DMBA-induced, croton oil-promoted skin tumor formation in Swiss Webster mice[1].
Trilaurin (25% w/w; p.o.; mixed into feed; daily; 10 weeks) exerts no toxic effects or induces no body weight changes in weanling rats[1].
Trilaurin (accounting for 36.3% w/w; administered via topical ocular instillation, 3 times) causes mild irritation in rabbits, with a Draize score of 2[1].
Trilaurin (36.3% w/w; administered percutaneously; delivered via occlusive patch) causes no skin irritation in rabbits[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Watanabe (WHHL) rabbits (6 months old); New Zealand white (NZW) rabbits (10 months old)[1]
Dosage: 6.5% w/w
Administration: oral; mixed in chow diet; 4 days, 1 week
Result: Increased plasma HDL cholesterol to 250% of baseline and apo A-I to 200% of baseline in 6-month-old WHHL rabbits.
Returned both parameters to baseline after Trilaurin was removed.
Produced similar increases in 10-month-old WHHL and NZW rabbits after 1 week of supplementation.
Animal Model: Rabbits[1]
Dosage: 36.3% w/w
Administration: ocular instillation; three times
Result: Produced a Draize score of 2, classified as mildly irritating to rabbit eyes.
Animal Model: Rabbits[1]
Dosage: 36.3% w/w
Administration: topical; occlusive patch application
Result: Observed no erythema or edema in any rabbits at 2 or 24 hours after patch removal, classifying the test substance as nonirritating to rabbit skin.
Molecular Weight

639.00

Formula

C39H74O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCC(OCC(OC(CCCCCCCCCCC)=O)COC(CCCCCCCCCCC)=O)=O
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 4 mg/mL (6.26 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : 1 mg/mL (1.56 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5649 mL 7.8247 mL 15.6495 mL
5 mM 0.3130 mL 1.5649 mL 3.1299 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.78%

SDS (393 KB)

COA (240 KB) HNMR (197 KB) RP-HPLC (237 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF / DMSO 1 mM 1.5649 mL 7.8247 mL 15.6495 mL 39.1236 mL
DMSO 5 mM 0.3130 mL 1.5649 mL 3.1299 mL 7.8247 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Trilaurin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trilaurin538-24-9Endogenous MetaboliteBiochemical Assay Reagentsdimethylbenzanthraceneneoplasmsmouse bone marrow cellsSwiss Webster micehepatic triacylglycerol lipasemouse plasmacroton oilNew Zealand white rabbitsSalmonella typhimuriumWatanabe rabbitsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Trilaurin
Cat. No.:
HY-126573
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.