2138488-38-5
Chemical Structure
ZT55
- CAS No.: 2138488-38-5
- Formula:C17H16N2O3
- Molecular Weight:296.32
IUPAC Name: 2-(1-hydroxy-1H-indol-3-yl)-N-(2-methoxyphenyl)acetamide
InChIKey: BXYUEIJHUBBZIJ-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC=C1OC)CC2=CN(O)C3=C2C=CC=C3
Biological Activity: ZT55 is an orally active and highly-selective JAK2 inhibitor with an IC50 value of 0.031 μM. ZT55 inhibits the proliferation of JAK2V617F-expressing HEL cell lines and induces apoptosis and cycle arrest. ZT-55 also effectively inhibits the growth of HEL xenograft tumours in a mice model. ZT-55 can be used in studies of myeloproliferative neoplasms, polycythemia vera and primary thrombocythemia[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ZT55 | 99.51% | ZT55 is an orally active and highly-selective JAK2 inhibitor with an IC50 value of 0.031 μM. ZT55 inhibits the proliferation of JAK2V617F-expressing HEL cell lines and induces apoptosis and cycle arrest. ZT-55 also effectively inhibits the growth of HEL xenograft tumours in a mice model. ZT-55 can be used in studies of myeloproliferative neoplasms, polycythemia vera and primary thrombocythemia. | ||||||||||||||||||||
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