1. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling Apoptosis
  2. JAK Apoptosis
  3. ZT55

ZT55 is an orally active and highly-selective JAK2 inhibitor with an IC50 value of 0.031 μM. ZT55 inhibits the proliferation of JAK2V617F-expressing HEL cell lines and induces apoptosis and cycle arrest. ZT-55 also effectively inhibits the growth of HEL xenograft tumours in a mice model. ZT-55 can be used in studies of myeloproliferative neoplasms, polycythemia vera and primary thrombocythemia.

For research use only. We do not sell to patients.

ZT55 Chemical Structure

ZT55 Chemical Structure

CAS No. : 2138488-38-5

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Top Publications Citing Use of Products

View All JAK Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ZT55 is an orally active and highly-selective JAK2 inhibitor with an IC50 value of 0.031 μM. ZT55 inhibits the proliferation of JAK2V617F-expressing HEL cell lines and induces apoptosis and cycle arrest. ZT-55 also effectively inhibits the growth of HEL xenograft tumours in a mice model. ZT-55 can be used in studies of myeloproliferative neoplasms, polycythemia vera and primary thrombocythemia[1].

IC50 & Target[1]

JAK2

0.031 μM (IC50)

In Vitro

ZT55 (0-100 μM; 48 h) inhibits the proliferation of JAK2V617F (+) HEL cells in a concentration-dependent manner (IC50=18.05 μM)[1].
ZT55 (12.5, 25, 50 μM; 24, 48, 72 h) inhibits the cell viability and induces apoptosis of HEL cells in a concentration- and time-dependent manner[1].
ZT55 (12.5, 25, 50 μM; 24 h) arrests HEL cells in the G2/M phase in a concentration-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: HEL cells (JAK2V617F(+))
Concentration: 0-100 μM
Incubation Time: 48 h
Result: Significantly inhibited proliferation in a concentration-dependent manner (IC50=18.05 μM).

Cell Viability Assay[1]

Cell Line: HEL cells
Concentration: 12.5, 25, 50 μM
Incubation Time: 24, 48, 72 h
Result: Inhibited viability of HEL cells in a concentration- and time-dependent manner.

Apoptosis Analysis[1]

Cell Line: HEL cells (JAK2V617F(+))
Concentration: 0-100 μM
Incubation Time: 24, 48, 72 h
Result: Induced cell apoptosis in a concentration- and time-dependent manner.

Cell Cycle Analysis[1]

Cell Line: HEL cells (JAK2V617F(+))
Concentration: 0-100 μM
Incubation Time: 24, 48, 72 h
Result: Significantly increased the number of HEL cells in the G2/M phase in a concentration-dependent manner.
In Vivo

ZT55 (100 mg/kg; p.o; once a day for 2 weeks) drastically attenuates the growth of subcutaneous HEL tumors in nude mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female, athymic BALB/c nude mice (6 to 8-week-old; JAK2V617F xenograft model)[1].
Dosage: 100 mg/kg
Administration: Oral administration; once a day for 2 weeks
Result: Induced marked reductions in tumor volume.
Molecular Weight

296.32

Formula

C17H16N2O3

CAS No.
SMILES

O=C(NC1=CC=CC=C1OC)CC2=CN(O)C3=C2C=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
ZT55
Cat. No.:
HY-124727
Quantity:
MCE Japan Authorized Agent: