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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
nonmalignant
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "nonmalignant" in MCE Product Catalog:
Cat. No.: HY-115970
Target:
Research Areas:
Tubulin inhibitor 21 (compound 6f), a chalcone- and melatonin- based hybrid, is a potent tubulin inhibitor. Tubulin inhibitor 21 induces a remarkable cytotoxic activity toward SW480 cells (IC50=0.26 μM) with lower effect against nonmalignant cells .
Cat. No.: HY-145379
CAS No.: 3039491-16-9
Category:
Infection Quinones Monophenols Anthraquinones Phenols Endogenous metabolite Disease Research Fields
Target:
Cat. No.: HY-P991425
Target:
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Cat. No.: HY-162721
Target:
Research Areas:
Anticancer agent 242 (7) possesses anticancer activity in A2780 (IC50 = 0.24 μM, ovarian adenocarcinoma), A2780cis (IC50 = 0.45 μM, resistant derivative of A2780), CCD18Co (IC50 = 0.59 μM, non-malignant human fibroblasts), A549 (IC50 = 0.32 μM, lung carcinoma), HT29 (IC50 = 0.26 μM, colorectal adenocarcinoma), and MCF7 (IC50 = 0.55 μM, breast adenocarcinoma) .
Cat. No.: HY-180260
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Anticancer agent 289 is a H2O2-responsive anticancer prodrug. Anticancer agent 289 exhibits H2O2-inducible DNA-alkylating activity, selectively inhibits the proliferation of high ROS-expressing cancer cells over nonmalignant cells, markedly suppresses tumor growth without observable toxicity in vivo. Anticancer agent 289 can be used for triple-negative breast cancer (TNBC) research .
Cat. No.: HY-181284
CAS No.: 2563902-57-6
Target:
G-quadruplex DNA/RNA Synthesis Ras PI3K Akt ERK Caspase Apoptosis
Research Areas:
BYBC‑1 is a selective G4‑RNA‑targeting ligand with high affinity forKRAS and NRAS G4‑RNAs (Kd = 0.05-0.28 μM). BYBC‑1 stabilizes G4‑RNA structures in KRAS and NRAS mRNA, blocks thePI3K/AKT and MAPK/ERK pathways, activates the DNA damage response (DDR), suppresses energy metabolism, and induces S‑phase arrest and apoptosis. BYBC‑1 exhibits high selectivity over non‑malignant fibroblasts and significantly inhibits the growth of HCT‑116 xenograft tumors in vivo. BYBC‑1 can be used for the study of colorectal cancer .
Cat. No.: HY-184870
CAS No.: 31621-87-1
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Polydioxanone is a colorless, crystalline semi-crystalline thermoplastic poly (ether-ester) bioabsorbable polymer. Polydioxanone serves as a hemostatic agent, biodegradable agent, degradant, lumen patency maintainer, as well as a temporary inducer of tracheal tissue injury and inflammation. Polydioxanone controls bone bleeding in biocompatible matrices, degrades via random hydrolytic scission and end-chain scission, with accelerated degradation occurring at pH <1.67, maintains tracheal lumen patency, and induces reversible tracheal epithelial necrosis, inflammation, fibrous tissue hyperplasia, and goblet cell hyperplasia. Polydioxanone can be used in research on bone bleeding, non-malignant tracheal stenosis, tracheobronchial stenosis, tracheobronchomalacia, and airway obstruction associated with vascular compression .
Cat. No.: HY-P11901
Cat. No.: HY-122670
CAS No.: 1627962-21-3
VS-II-173 is a pan-Pim kinase inhibitor with IC50 values of 0.07 μM and 0.02 μM for Pim1 and Pim3, respectively, and a residual activity of 46% for Pim2 at 1 μM. VS-II-173 also inhibits kinases such as HIPK2, PRK2, RSK1, DYRK1a and AMPKα1, selectively inhibiting acute myeloid leukemia (AML) cells with significantly lower toxicity to non-malignant cells (EC50 > 30 μM). VS-II-173 weakens the phosphorylation of substrates such as Stat5 (Y694), MDM2 (S166), Bad (S112), and 4E-BP1 (T37/46) by inhibiting Pim kinase-mediated signaling pathways, blocking pro-survival signals in AML cells and inducing apoptosis. VS-II-173 synergistically enhances anti-AML activity when combined with Daunorubicin (HY-13062A). VS-II-173 can be used in AML research, especially for AML with FLT3-ITD mutations and NPM1 mutations .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
