31621-87-1
Chemical Structure
Biological Activity: Polydioxanone is a colorless, crystalline semi-crystalline thermoplastic poly (ether-ester) bioabsorbable polymer. Polydioxanone serves as a hemostatic agent, biodegradable agent, degradant, lumen patency maintainer, as well as a temporary inducer of tracheal tissue injury and inflammation. Polydioxanone controls bone bleeding in biocompatible matrices, degrades via random hydrolytic scission and end-chain scission, with accelerated degradation occurring at pH <1.67, maintains tracheal lumen patency, and induces reversible tracheal epithelial necrosis, inflammation, fibrous tissue hyperplasia, and goblet cell hyperplasia. Polydioxanone can be used in research on bone bleeding, non-malignant tracheal stenosis, tracheobronchial stenosis, tracheobronchomalacia, and airway obstruction associated with vascular compression[1][2][3][4][5][6][7].
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Polydioxanone | Polydioxanone is a colorless, crystalline semi-crystalline thermoplastic poly (ether-ester) bioabsorbable polymer. Polydioxanone serves as a hemostatic agent, biodegradable agent, degradant, lumen patency maintainer, as well as a temporary inducer of tracheal tissue injury and inflammation. Polydioxanone controls bone bleeding in biocompatible matrices, degrades via random hydrolytic scission and end-chain scission, with accelerated degradation occurring at pH <1.67, maintains tracheal lumen patency, and induces reversible tracheal epithelial necrosis, inflammation, fibrous tissue hyperplasia, and goblet cell hyperplasia. Polydioxanone can be used in research on bone bleeding, non-malignant tracheal stenosis, tracheobronchial stenosis, tracheobronchomalacia, and airway obstruction associated with vascular compression. | |||||||||||||||||||||
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References
- [1]. Mattei FV, et al. Synthetic absorbable hemostatic composition. U.S. Patent 4,440,789. 1984 Apr 3.
- [2]. Goonoo N, et al. Polydioxanone-based bio-materials for tissue engineering and drug/gene delivery applications. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2015 Nov;97(Pt B):371-91. [Content Brief]
- [3]. Boland ED, et al. Electrospinning polydioxanone for biomedical applications. Acta biomaterialia. 2005 Jan;1(1):115-23. [Content Brief]
- [4]. Martins JA, et al. Polydioxanone implants: A systematic review on safety and performance in patients. Journal of biomaterials applications. 2020 Feb;34(7):902-916. [Content Brief]
- [5]. Lelkes KD, et al. A comprehensive study on the degradation process of medical-grade polydioxanone at low pH. Polymer Testing. 2024.
- [6]. Stehlik L, et al. Biodegradable polydioxanone stents in the treatment of adult patients with tracheal narrowing. BMC pulmonary medicine. 2015 Dec 21;15:164. [Content Brief]
- [7]. Novotny L, et al. Novel biodegradable polydioxanone stents in a rabbit airway model. The Journal of thoracic and cardiovascular surgery. 2012 Feb;143(2):437-44. [Content Brief]
