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Results for "

nsP2

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

1

Peptides

1

Recombinant Proteins

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-161762
    RA-0002034

    RA-2034

    		 CHIKV Virus Protease Infection
    RA-0002034 is a Chikungunya virus (CHIKV) nsP2 protease inhibitor with an IC50 of 58 nM. RA-0002034 covalently modifies the catalytic cysteine in a site-specific manner .
    RA-0002034
  • HY-175279
    CHIKV nsP2 protease-IN-3

    		Virus Protease Infection
    CHIKV nsP2 protease-IN-3 (Compound 5) is an irreversible covalent inhibitor targeting the nonstructural protein 2 (nsP2) cysteine protease of chikungunya virus (CHIKV) (IC50=0.5 μM). CHIKV nsP2 protease-IN-3 inhibits viral RNA replication. CHIKV nsP2 protease-IN-3 is promising for research of alphaviruses .
    CHIKV nsP2 protease-IN-3
  • HY-176268
    SGC-NSP2hel-1

    RA-0188293; RA-nsP2-1

    		 DNA/RNA Synthesis Virus Protease Flavivirus Infection
    SGC-NSP2hel-1 (RA-0188293), a chemical probe, is a potent, specific and orally active nsP2 inhibitor. SGC-NSP2hel-1 has broad spectrum activity against multiple alphaviruses of the nsP2 helicase with a CC50 > 250 μM. SGC-NSP2hel-1 (RA-0188293) shows selectivity index > 4000 against human RNA helicases. SGC-NSP2hel-1 reduces virus replication and limited virus-induced pathology by forming a stable complex with nsP2 and ATP in a preclinical small animal model of CHIKV disease.
    SGC-NSP2hel-1
  • HY-175234
    CHIKV nsP2 protease-IN-2

    		DNA/RNA Synthesis Virus Protease Infection
    CHIKV nsP2 protease-IN-2 (Compound 2o) is a allosteric nonstructural protein 2 helicase (nsP2hel) inhibitor with IC50s of 0.5  μM and 0.9  μM for nsP2 ATPase and RNA unwindase, respectively. CHIKV nsP2 protease-IN-2 has broad-spectrum antialphaviral activity against chikungunya virus (CHIKV), Mayaro virus (MAYV), and Venezuelan equine encephalitis virus (VEEV) (EC50 of 120 nM for CHIKV-nLuc). CHIKV nsP2 protease-IN-2 can be used for alphaviruses infections research .
    CHIKV nsP2 protease-IN-2
  • HY-169102
    CHIKV nsP2 protease-IN-1

    		CHIKV Virus Protease Infection
    CHIKV nsP2 protease-IN-1(compound J13) is an oral active non-structural protein 2 protease inhibitor with the EC50 of 0.39 μM aganist of CHIKV S27. CHIKV nsP2 protease-IN-1 can be used for study of Chikungunya virus .
    CHIKV nsP2 protease-IN-1
  • HY-168050
    SGC-NSP2PRO-1

    		CHIKV Virus Protease Infection
    SGC-NSP2PRO-1 is a potent irreversible covalent inhibitor of Chikungunya (CHIKV) nsP2 cysteine protease with an IC50 value of 60 nM. SGC-NSP2PRO-1 demonstrates potent antialphavirus activity, inhibiting CHIKV and VEEV replication with EC50 = 0.01 and 0.3 µM, respectively .
    SGC-NSP2PRO-1
  • HY-P11302
    DABCYL-RAGGYIFS-(E-EDANS)-NH2

    		CHIKV Virus Protease Infection
    DABCYL-RAGGYIFS-(E-EDANS)-NH2, an octapeptide, is a FRET-based substrate peptide of CHIKV nsP2protease with highly sensitivity. DABCYL-RAGGYIFS-(E-EDANS)-NH2 can be cleaved by the active CHIKV nsP2protease, separating fluorophore and quencher and resulting in an increase of fluorescence signal. DABCYL-RAGGYIFS-(E-EDANS)-NH2 can used for the determination of CHIKV nsP2protease activity .
    DABCYL-RAGGYIFS-(E-EDANS)-NH2
  • HY-161762A
    (E/Z)-RA-0002034

    (E/Z)-RA-2034

    		 Influenza Virus CHIKV Cancer
    (E/Z)-RA-0002034 is a Chikungunya virus (CHIKV) nsP2 protease inhibitor with IC50 of 58 nM. RA-0002034 covalently modifies the catalytic cysteine in a site-specific manner.
    (E/Z)-RA-0002034
  • HY-171261
    CID15997213

    		Virus Protease Infection
    CID15997213 is a blood-brain barrier penetrating antiviral agent. CID15997213 targets the amino-terminal domain of the VEEV nonstructural protein 2 (nsP2). CID15997213 shows alphavirus-specific antiviral effect, inhibiting VEEV and Western equine encephalitis virus .
    CID15997213
  • HY-181969
    BFB78

    		Virus Protease Infection
    BFB78 is a blood-brain barrier-permeable nsP2 protease inhibitor. BFB78 potently and broadly inhibits the purified nsP2 proteases of various alphaviruses, with IC50 values ranging from 21.6 nM (Mayaro virus; MAYV) to 130.7 nM (Chikungunya virus; CHIKV). BFB78 blocks viral replication in cell culture systems and reduces viral titers in the brains of mice. BFB78 can be used in studies related to Venezuelan equine encephalitis virus (VEEV) infection .
    BFB78
  • HY-RS01398
    BCAR3 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    BCAR3 Human Pre-designed siRNA Set A contains three designed siRNAs for BCAR3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    BCAR3 Human Pre-designed siRNA Set A
    BCAR3 Human Pre-designed siRNA Set A
  • HY-RS12330
    RTN2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    RTN2 Human Pre-designed siRNA Set A contains three designed siRNAs for RTN2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    RTN2 Human Pre-designed siRNA Set A
    RTN2 Human Pre-designed siRNA Set A

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